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    GLN1.3 glutamine synthetase 1.3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821050, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLN1.3
    Official Full Name
    glutamine synthetase 1.3
    Primary source
    TAIR:AT3G17820
    Locus tag
    AT3G17820
    See related
    Araport:AT3G17820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA GLUTAMINE SYNTHASE CLONE KB6; ATGSKB6; GLN1;3; glutamine synthetase 1.3; GLUTAMINE SYNTHETASE 1;3
    Summary
    encodes a cytosolic glutamine synthetase, the enzyme has low affinity with substrate ammonium
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    Genomic context

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    See GLN1.3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (6097201..6099595)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene alanine-tRNA ligase, putative (DUF760) Neighboring gene ncRNA Neighboring gene pyrimidine 1 Neighboring gene Molecular chaperone Hsp40/DnaJ family protein Neighboring gene receptor-like kinase 902

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The significance of the two cytosolic glutamine synthetase enzymes, GLN1;3 and GLN1;5, in the context of seed development and germination in Arabidopsis thaliana. Moreira E, et al. Plant Physiol Biochem, 2024 May. PMID 38657550
    2. The glutamine synthetase gene family of Arabidopsis thaliana: light-regulation and differential expression in leaves, roots and seeds. Peterman TK, et al. Mol Gen Genet, 1991 Nov. PMID 1684022
    3. The plant defensin gene AtPDF2.1 mediates ammonium metabolism by regulating glutamine synthetase activity in Arabidopsis thaliana. Yao J, et al. BMC Plant Biol, 2019 Dec 16. PMID 31842759, Free PMC Article
    4. Three cytosolic glutamine synthetase isoforms localized in different-order veins act together for N remobilization and seed filling in Arabidopsis. Moison M, et al. J Exp Bot, 2018 Aug 14. PMID 29873769, Free PMC Article
    5. Carbon and amino acids reciprocally modulate the expression of glutamine synthetase in Arabidopsis. Oliveira IC, et al. Plant Physiol, 1999 Sep. PMID 10482686, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The significance of the two cytosolic glutamine synthetase enzymes, GLN1;3 and GLN1;5, in the context of seed development and germination in Arabidopsis thaliana.
      Title: The significance of the two cytosolic glutamine synthetase enzymes, GLN1;3 and GLN1;5, in the context of seed development and germination in Arabidopsis thaliana.
    2. AtPDF2.1 affects ammonium metabolism by regulating the expression of GLN1.3 and GLN1.5 through a yet unidentified mechanism.
      Title: The plant defensin gene AtPDF2.1 mediates ammonium metabolism by regulating glutamine synthetase activity in Arabidopsis thaliana.
    3. Glutamine biosynthesis for N-remobilization occurs in veins of all orders (major and minor) in leaves, it is mainly catalysed by the three major GS1 isoforms (GLN1;1, GLN1;2, and GLN1;3), and it is alternatively supported by AS2 in the veins and GS2 in the mesophyll cells.
      Title: Three cytosolic glutamine synthetase isoforms localized in different-order veins act together for N remobilization and seed filling in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112663.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding HDA PubMed 
    enables glutamine synthetase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within glutamine biosynthetic process TAS
    Traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within nitrate assimilation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    glutamine synthetase 1.3
    NP_188409.1
    • glutamine synthetase 1.3 (GLN1.3); FUNCTIONS IN: glutamate-ammonia ligase activity, copper ion binding; INVOLVED IN: in 6 processes; LOCATED IN: cytosol, cytosolic ribosome, chloroplast, plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine synthetase, catalytic domain (InterPro:IPR008146), Glutamine synthetase, beta-Grasp (InterPro:IPR008147), Glutamine synthetase/guanido kinase, catalytic domain (InterPro:IPR014746); BEST Arabidopsis thaliana protein match is: glutamine synthase clone R1 (TAIR:AT5G37600.1); Has 10255 Blast hits to 10251 proteins in 3319 species: Archae - 147; Bacteria - 5273; Metazoa - 413; Fungi - 249; Plants - 1750; Viruses - 3; Other Eukaryotes - 2420 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      6097201..6099595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112663.3 → NP_188409.1  glutamine synthetase 1.3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188409.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q5PNX0, Q84W44, Q9LVI8
      UniProtKB/TrEMBL
      A0A178VNQ6, A0A5S9XEP2
      Conserved Domains (1) summary
      PLN02284
      Location:1 → 354
      PLN02284; glutamine synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LVI8.1

    Gene LinkOut

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