U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ROPGEF8 RHO guanyl-nucleotide exchange factor 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822058, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ROPGEF8
    Official Full Name
    RHO guanyl-nucleotide exchange factor 8
    Primary source
    TAIR:AT3G24620
    Locus tag
    AT3G24620
    See related
    Araport:AT3G24620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATROPGEF8; RHO guanyl-nucleotide exchange factor 8; ROP (rho of plants) guanine nucleotide exchange factor 8
    Summary
    Encodes a member of KPP-like gene family, homolog of KPP (kinase partner protein) gene in tomato. Also a member of the RopGEF (guanine nucleotide exchange factor) family, containing the novel PRONE domain (plant-specific Rop nucleotide exchanger), which is exclusively active towards members of the Rop subfamily.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ROPGEF8 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    7
    Sequence:
    Chromosome: 3; NC_003074.8 (8980400..8982903, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene lyase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The phosphomimetic mutation of an evolutionarily conserved serine residue affects the signaling properties of Rho of plants (ROPs). Fodor-Dunai C, et al. Plant J, 2011 May. PMID 21309864
    2. 3D structure of a binary ROP-PRONE complex: the final intermediate for a complete set of molecular snapshots of the RopGEF reaction. Thomas C, et al. Biol Chem, 2009 May-Jun. PMID 19335195
    3. Molecular basis for the substrate specificity of plant guanine nucleotide exchange factors for ROP. Fricke I, et al. FEBS Lett, 2009 Jan 5. PMID 19070620
    4. Structural evidence for a common intermediate in small G protein-GEF reactions. Thomas C, et al. Mol Cell, 2007 Jan 12. PMID 17218277
    5. ROPGEF1 and ROPGEF4 are functional regulators of ROP11 GTPase in ABA-mediated stomatal closure in Arabidopsis. Li Z, et al. FEBS Lett, 2012 May 7. PMID 22500990

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural modeling implies that phosphorylation of ROP4 (RHO-LIKE GTP BINDING PROTEIN 4) at S74 disturbs substrate recognition by PRONE8.
      Title: The phosphomimetic mutation of an evolutionarily conserved serine residue affects the signaling properties of Rho of plants (ROPs).
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_113373.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    RHO guanyl-nucleotide exchange factor 8
    NP_189105.1
    • RHO guanyl-nucleotide exchange factor 8 (ROPGEF8); CONTAINS InterPro DOMAIN/s: Rop nucleotide exchanger, PRONE (InterPro:IPR005512); BEST Arabidopsis thaliana protein match is: RHO guanyl-nucleotide exchange factor 9 (TAIR:AT4G13240.1); Has 311 Blast hits to 307 proteins in 17 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 309; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8980400..8982903 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113373.2 → NP_189105.1  RHO guanyl-nucleotide exchange factor 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189105.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1PEM4, Q9LV40
      UniProtKB/TrEMBL
      A0A5S9XFK9, A0A654FAC9
      Conserved Domains (1) summary
      pfam03759
      Location:84 → 433
      PRONE; PRONE (Plant-specific Rop nucleotide exchanger)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LV40.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools