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    AGC2-1 AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822119, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGC2-1
    Official Full Name
    AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein
    Primary source
    TAIR:AT3G25250
    Locus tag
    AT3G25250
    See related
    Araport:AT3G25250
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGC2; AGC2 kinase 1; AtOXI1; OXI1; oxidative signal-inducible1
    Summary
    Arabidopsis protein kinase
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    Genomic context

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    See AGC2-1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (9195334..9197126)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene rotamase FKBP 1 Neighboring gene sulfate/thiosulfate import ATP-binding protein, putative (DUF506) Neighboring gene Major facilitator superfamily protein Neighboring gene low-molecular-weight cysteine-rich 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. OXIDATIVE SIGNAL-INDUCIBLE1 induces immunity by coordinating N-hydroxypipecolic acid, salicylic acid, and camalexin synthesis. Rawat AA, et al. New Phytol, 2023 Feb. PMID 36319610, Free PMC Article
    2. OXI1 kinase plays a key role in resistance of Arabidopsis towards aphids (Myzus persicae). Shoala T, et al. Transgenic Res, 2018 Aug. PMID 29777502
    3. Singlet Oxygen-Induced Cell Death in Arabidopsis under High-Light Stress Is Controlled by OXI1 Kinase. Shumbe L, et al. Plant Physiol, 2016 Mar. PMID 26747288, Free PMC Article
    4. The role of the kinase OXI1 in cadmium- and copper-induced molecular responses in Arabidopsis thaliana. Smeets K, et al. Plant Cell Environ, 2013 Jun. PMID 23278806
    5. The phosphoproteome of Arabidopsis plants lacking the oxidative signal-inducible1 (OXI1) protein kinase. Howden AJM, et al. New Phytol, 2011 Apr. PMID 21175636

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6.
      Title: AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6.
    2. OXIDATIVE SIGNAL-INDUCIBLE1 induces immunity by coordinating N-hydroxypipecolic acid, salicylic acid, and camalexin synthesis.
      Title: OXIDATIVE SIGNAL-INDUCIBLE1 induces immunity by coordinating N-hydroxypipecolic acid, salicylic acid, and camalexin synthesis.
    3. OXI1 and DAD Regulate Light-Induced Cell Death Antagonistically through Jasmonate and Salicylate Levels.
      Title: OXI1 and DAD Regulate Light-Induced Cell Death Antagonistically through Jasmonate and Salicylate Levels.
    4. The results suggest that resistance in oxi1-2 mutants is through induction of callose deposition via MAPKs resulting in ROS induction as an early response.
      Title: OXI1 kinase plays a key role in resistance of Arabidopsis towards aphids (Myzus persicae).
    5. Results show that OXI1 is a regulator of singlet oxygen ((1)O2)-induced programmed cell death (PCD).
      Title: Singlet Oxygen-Induced Cell Death in Arabidopsis under High-Light Stress Is Controlled by OXI1 Kinase.
    6. This study has identified a range of candidate proteins from the OXI1 signalling pathway.
      Title: The phosphoproteome of Arabidopsis plants lacking the oxidative signal-inducible1 (OXI1) protein kinase.
    7. induction of Cu/Zn superoxide dismutases in Cu-exposed leaves regulated by OXI1 in a manner that involves fluctuations in the expression of miRNA398
      Title: The role of the kinase OXI1 in cadmium- and copper-induced molecular responses in Arabidopsis thaliana.
    8. Piriformospora indica-stimulated growth response is mediated by a pathway consisting of the PLD-PDK1-OXI1 cascade.
      Title: The OXI1 kinase pathway mediates Piriformospora indica-induced growth promotion in Arabidopsis.
    9. These results demonstrate that PTI1-4 signals via OXI1 and MPK6 signalling cascades.
      Title: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases.
    10. Null oxi1 mutants are more susceptible to Pseudomonas syringae compared with the wild type.
      Title: OXI1 protein kinase is required for plant immunity against Pseudomonas syringae in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_113431.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein
    NP_189162.1
    • AGC2-1; FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: hypocotyl, root, stamen, pollen tube; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), AGC-kinase, C-terminal (InterPro:IPR000961), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein (TAIR:AT4G13000.1); Has 87313 Blast hits to 84259 proteins in 2947 species: Archae - 68; Bacteria - 13079; Metazoa - 33183; Fungi - 11494; Plants - 12113; Viruses - 235; Other Eukaryotes - 17141 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9195334..9197126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113431.6 → NP_189162.1  AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189162.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1L4U5, Q9LSF1
      UniProtKB/TrEMBL
      A0A5S9XFM3
      Conserved Domains (2) summary
      smart00220
      Location:18 → 329
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:13 → 354
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LSF1.1

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