LOH2 LAG1 homologue 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: LOH2
Official Full Name: LAG1 homologue 2
Primary source: TAIR:AT3G19260
Locus tag: AT3G19260
See related: Araport:AT3G19260
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: LAG1 HOMOLOG 2; LAG1 homologue 2; LONGEVITY ASSURANCE GENE1 HOMOLOG 2
Summary: LAG1 homolog . Loss of function mutant is sensitive to AAL-toxin. LOH2 is presumed to function in sphingolipid metabolism. It encodes a ceramide synthase essential for production of LCFA-ceramides (mainly C26).
NEW: Try the new Gene table
Try the new Transcript table

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The role of At3g19260 in sphingolipid metabolism, mycotoxin resistance and cell death.
Title: Overexpression of Arabidopsis Ceramide Synthases Differentially Affects Growth, Sphingolipid Metabolism, Programmed Cell Death, and Mycotoxin Resistance.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_112813.2

Function	Evidence Code	Pubs
enables sphingosine N-acyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in ceramide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in endomembrane system organization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within long-chain fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to molecule of fungal origin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	HDA more info	PubMed

NP_188557.1

LAG1 homologue 2 (LOH2); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: response to molecule of fungal origin; LOCATED IN: Golgi apparatus, endoplasmic reticulum, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Longevity assurance, LAG1/LAC1 (InterPro:IPR016439), TRAM/LAG1/CLN8 homology domain (InterPro:IPR006634); BEST Arabidopsis thaliana protein match is: LAG1 longevity assurance homolog 3 (TAIR:AT1G13580.3); Has 1277 Blast hits to 1277 proteins in 227 species: Archae - 0; Bacteria - 0; Metazoa - 612; Fungi - 306; Plants - 183; Viruses - 3; Other Eukaryotes - 173 (source: NCBI BLink).