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    EHD2 EPS15 homology domain 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825902, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EHD2
    Official Full Name
    EPS15 homology domain 2
    Primary source
    TAIR:AT4G05520
    Locus tag
    AT4G05520
    See related
    Araport:AT4G05520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEHD2; EPS15 homology domain 2; T1J24.10; T1J24_10
    Summary
    Encodes AtEHD2, one of the Arabidopsis Eps15 homology domain proteins involved in endocytosis (AtEHD1, At3g20290).
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    Genomic context

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    See EHD2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    16
    Sequence:
    Chromosome: 4; NC_003075.7 (2804403..2808015)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene nucleoporin GLE1-like protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The coiled-coil domain of EHD2 mediates inhibition of LeEix2 endocytosis and signaling. Bar M, et al. PLoS One, 2009 Nov 19. PMID 19936242, Free PMC Article
    2. AtEHDs, novel Arabidopsis EH-domain-containing proteins involved in endocytosis. Bar M, et al. Plant J, 2008 Sep. PMID 18547399
    3. The function of EHD2 in endocytosis and defense signaling is affected by SUMO. Bar M, et al. Plant Mol Biol, 2014 Mar. PMID 24154852
    4. Identification and characterization of nuclear pore complex components in Arabidopsis thaliana. Tamura K, et al. Plant Cell, 2010 Dec. PMID 21189294, Free PMC Article
    5. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that a mutant form of EHD2, possessing a defective SUMOylation site, has an increased nuclear abundance, can no longer be SUMOylated.
      Title: The function of EHD2 in endocytosis and defense signaling is affected by SUMO.
    2. EHD2/At4g05520 is involved in endocytosis, and overexpression inhibits endocytosis.
      Title: AtEHDs, novel Arabidopsis EH-domain-containing proteins involved in endocytosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_116790.3
    NM_202788.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    EPS15 homology domain 2
    NP_567299.2
    • EPS15 homology domain 2 (EHD2); FUNCTIONS IN: GTP binding, GTPase activity, calcium ion binding; INVOLVED IN: endocytosis; LOCATED IN: plasma membrane, microsome, membrane, cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: EF-HAND 2 (InterPro:IPR018249), EPS15 homology (EH) (InterPro:IPR000261), Dynamin, GTPase domain (InterPro:IPR001401), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: EPS15 homology domain 1 (TAIR:AT3G20290.2); Has 2647 Blast hits to 1775 proteins in 263 species: Archae - 2; Bacteria - 75; Metazoa - 1675; Fungi - 405; Plants - 219; Viruses - 0; Other Eukaryotes - 271 (source: NCBI BLink).
    NP_974517.1
    • EPS15 homology domain 2 (EHD2); FUNCTIONS IN: GTP binding, GTPase activity, calcium ion binding; INVOLVED IN: endocytosis; LOCATED IN: plasma membrane, microsome, membrane, cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: EF-HAND 2 (InterPro:IPR018249), EPS15 homology (EH) (InterPro:IPR000261), Dynamin, GTPase domain (InterPro:IPR001401), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048); BEST Arabidopsis thaliana protein match is: EPS15 homology domain 1 (TAIR:AT3G20290.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      2804403..2808015
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116790.3 → NP_567299.2  EPS15 homology domain 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567299.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3LF48, F4JGH2, Q9S9W1
      UniProtKB/TrEMBL
      A0A654FM18
      Conserved Domains (4) summary
      cd09913
      Location:199 → 443
      EHD; Eps15 homology domain (EHD), C-terminal domain
      cd00052
      Location:20 → 86
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam13499
      Location:24 → 78
      EF-hand_7; EF-hand domain pair
      pfam16880
      Location:163 → 195
      EHD_N; N-terminal EH-domain containing protein

    2. NM_202788.1 → NP_974517.1  EPS15 homology domain 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974517.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FM18
      Conserved Domains (4) summary
      cd09913
      Location:198 → 442
      EHD; Eps15 homology domain (EHD), C-terminal domain
      cd00052
      Location:20 → 86
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam13499
      Location:24 → 78
      EF-hand_7; EF-hand domain pair
      pfam16880
      Location:162 → 194
      EHD_N; N-terminal EH-domain containing protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B3LF48.1

    Gene LinkOut

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