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    GPX6 glutathione peroxidase 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826765, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GPX6
    Official Full Name
    glutathione peroxidase 6
    Primary source
    TAIR:AT4G11600
    Locus tag
    AT4G11600
    See related
    Araport:AT4G11600
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATGPX6; glutathione peroxidase 6; LSC803; PHGPX; T5C23.30; T5C23_30
    Summary
    Encodes glutathione peroxidase.
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    Genomic context

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    See GPX6 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (7009769..7011406, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Haloacid dehalogenase-like hydrolase (HAD) superfamily protein Neighboring gene RNI-like superfamily protein Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene ncRNA Neighboring gene C2 calcium/lipid-binding plant phosphoribosyltransferase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Probing the molecular toxic mechanism of lead (II) ions with glutathione peroxidase 6 from Arabidopsis thaliana. Tan L, et al. Spectrochim Acta A Mol Biomol Spectrosc, 2020 Feb 5. PMID 31629975
    2. Putative phospholipid hydroperoxide glutathione peroxidase gene from Arabidopsis thaliana induced by oxidative stress. Sugimoto M, et al. Genes Genet Syst, 1997 Oct. PMID 9511228
    3. Glutathione peroxidase-like enzymes cover five distinct cell compartments and membrane surfaces in Arabidopsis thaliana. Attacha S, et al. Plant Cell Environ, 2017 Aug. PMID 28102911
    4. Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways. Rodriguez Milla MA, et al. Plant J, 2003 Dec. PMID 14617062
    5. Identification of new intrinsic proteins in Arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2004 Jul. PMID 15060130

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Detailed binding mode between lead (II) ions and glutathione peroxidase 6 from Arabidopsis thaliana.
      Title: Probing the molecular toxic mechanism of lead (II) ions with glutathione peroxidase 6 from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_117229.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glutathione peroxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables phospholipid-hydroperoxide glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular oxidant detoxification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    glutathione peroxidase 6
    NP_192897.2
    • glutathione peroxidase 6 (GPX6); FUNCTIONS IN: glutathione peroxidase activity; INVOLVED IN: response to oxidative stress, response to cadmium ion, response to salt stress, response to metal ion; LOCATED IN: cytosol, mitochondrion, chloroplast, plasma membrane; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin-like fold (InterPro:IPR012336), Glutathione peroxidase (InterPro:IPR000889); BEST Arabidopsis thaliana protein match is: glutathione peroxidase 7 (TAIR:AT4G31870.1); Has 7601 Blast hits to 7600 proteins in 1766 species: Archae - 2; Bacteria - 3728; Metazoa - 790; Fungi - 210; Plants - 383; Viruses - 8; Other Eukaryotes - 2480 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7009769..7011406 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117229.4 → NP_192897.2  glutathione peroxidase 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192897.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48646, Q94BV3
      UniProtKB/TrEMBL
      A0A5S9XRN7, A0A654FNA6
      Conserved Domains (2) summary
      pfam00578
      Location:75 → 210
      AhpC-TSA; AhpC/TSA family
      cl00388
      Location:66 → 229
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O48646.2

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