CCS52A2 cell cycle switch protein 52 A2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CCS52A2
Official Full Name: cell cycle switch protein 52 A2
Primary source: TAIR:AT4G11920
Locus tag: AT4G11920
See related: Araport:AT4G11920
Gene type: protein coding
RNA name: miRNA
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: cell cycle switch protein 52 A2; cell cycle switch protein 52 A2; FIZZY-RELATED 1; FZR1; T26M18.130; T26M18_130
Summary: Encodes a putative activator of the anaphase-promoting complex/cyclosome. Promotes exit from the cell cycle and entry into the endocycle leading to endoreduplication. Mutation of this gene results in abnormal shoot apical meristem development. It likely regulates the development of meristems by indirectly interacting with WUS and CLV3.
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Genomic context

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See CCS52A2 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 9

Sequence:: Chromosome: 4; NC_003075.7 (7160243..7163427, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plant lineage-specific PIKMIN1 drives APC/CCCS52A2 E3-ligase activity-dependent cell division.
Title: Plant lineage-specific PIKMIN1 drives APC/CCCS52A2 E3-ligase activity-dependent cell division.
The Cyclin CYCA3;4 Is a Postprophase Target of the APC/C(CCS52A2) E3-Ligase Controlling Formative Cell Divisions in Arabidopsis.
Title: The Cyclin CYCA3;4 Is a Postprophase Target of the APC/C(CCS52A2) E3-Ligase Controlling Formative Cell Divisions in Arabidopsis.
The data illustrate cooperative activity of the APC/C(CCS52A1) and APC/C(CCS52A2) complexes during root and trichome development, but functional interdependency during leaf development. Furthermore, we found APC/C(CCS52A1) activity to control CCS52A2 expression. We conclude that interdependency of CCS52A-controlled APC/C activity is controlled in a tissue-specific manner.
Title: Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
A ccs52A2 mutation did not affect the level or pattern of cyclin B1;1 expression, indicating that CCS52A2 does not mediate the effect of auxin on cyclin B1;1.
Title: ABCB19-mediated polar auxin transport modulates Arabidopsis hypocotyl elongation and the endoreplication variant of the cell cycle.
Findings support both complementary and dose-dependent actions for the Arabidopsis CCS52A isoforms in plant development and demonstrate that elevated ectopic CCS52A expression positively correlates with organ size, opening a route to higher biomass production. [CCS52A2]
Title: Complementary and dose-dependent action of AtCCS52A isoforms in endoreduplication and plant size control.
The CCS52A2 gene is a mediator that functions together with meristematic genes to regulate meristem organization.
Title: CCS52A2/FZR1, a cell cycle regulator, is an essential factor for shoot apical meristem maintenance in Arabidopsis thaliana.
Studies indicate that the APC is composed of at least 11 subunits and associates with additional regulatory activators CDC20/CCS52 during mitosis and interphase cycles.
Title: Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plants.
CCS52A2 acts directly in the distal region of the root meristem to control identity of the quiescent center (QC) cells and stem cell maintenance.
Title: APC/C-CCS52A complexes control meristem maintenance in the Arabidopsis root.
the atypical E2F transcription factor E2Fe/DEL1 controls the expression of the CDH1/FZR orthologous CCS52A2 gene from Arabidopsis thaliana
Title: Atypical E2F activity restrains APC/CCCS52A2 function obligatory for endocycle onset.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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mature miRNA accession:MIMAT0032778

NM_117262.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within maintenance of shoot apical meristem identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: cell cycle switch protein 52 A2

NP_192929.2

cell cycle switch protein 52 A2 (CCS52A2); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: FIZZY-related 2 (TAIR:AT4G22910.1); Has 45928 Blast hits to 23758 proteins in 696 species: Archae - 56; Bacteria - 7022; Metazoa - 17569; Fungi - 10333; Plants - 5514; Viruses - 0; Other Eukaryotes - 5434 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

7160243..7163427 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117262.3 → NP_192929.2 cell cycle switch protein 52 A2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192929.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8VZS9, Q9T060

UniProtKB/TrEMBL

A0A178UX11, A0A5S9XRH1, A0A654FNJ5

Conserved Domains (2) summary

sd00039
Location:212 → 249

7WD40; WD40 repeat [structural motif]

cl29593
Location:212 → 451

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...