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    UPL5 ubiquitin protein ligase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 826870, updated on 18-Sep-2024

    Summary

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    Official Symbol
    UPL5
    Official Full Name
    ubiquitin protein ligase 5
    Primary source
    TAIR:AT4G12570
    Locus tag
    AT4G12570
    See related
    Araport:AT4G12570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T1P17.160; T1P17_160; ubiquitin protein ligase 5
    Summary
    Knock-out mutants showed accelerated senescence of leaves.
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    Genomic context

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    See UPL5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (7445278..7449205)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene uncharacterized protein Neighboring gene ER membrane protein complex subunit-like protein (Protein of unknown function DUF106, transmembrane)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A HECT E3 ubiquitin ligase negatively regulates Arabidopsis leaf senescence through degradation of the transcription factor WRKY53. Miao Y, et al. Plant J, 2010 Jul. PMID 20409006
    2. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. WRKY53 is ubiquitinated by UPL5 which regulates the WRKY53-mediated leaf senescence pathway.
      Title: A HECT E3 ubiquitin ligase negatively regulates Arabidopsis leaf senescence through degradation of the transcription factor WRKY53.
    Submit: New GeneRIF Correction

    General gene information

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    NM_117327.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hydrogen peroxide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to jasmonic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin protein ligase 5
    NP_192994.1
    • ubiquitin protein ligase 5 (UPL5); CONTAINS InterPro DOMAIN/s: Ubiquitin subgroup (InterPro:IPR019956), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955), HECT (InterPro:IPR000569); BEST Arabidopsis thaliana protein match is: ubiquitin-protein ligase 1 (TAIR:AT1G55860.1); Has 13201 Blast hits to 8328 proteins in 676 species: Archae - 0; Bacteria - 15; Metazoa - 6234; Fungi - 1825; Plants - 2664; Viruses - 167; Other Eukaryotes - 2296 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      7445278..7449205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117327.3 → NP_192994.1  ubiquitin protein ligase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192994.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SU29
      UniProtKB/TrEMBL
      A0A178V5H1, A0A5S9XRM7
      Conserved Domains (4) summary
      smart00119
      Location:540 → 860
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00213
      Location:95 → 167
      UBQ; Ubiquitin homologues
      cd00078
      Location:511 → 871
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00240
      Location:102 → 168
      ubiquitin; Ubiquitin family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SU29.1

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