AZI1 azelaic acid induced 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AZI1
Official Full Name: azelaic acid induced 1
Primary source: TAIR:AT4G12470
Locus tag: AT4G12470
See related: Araport:AT4G12470
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: azelaic acid induced 1; T1P17.60; T1P17_60
Summary: Encodes AZI1 (AZELAIC ACID INDUCED 1). Involved in the priming of salicylic acid induction and systemic immunity triggered by pathogen or azelaic acid.
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Genomic context

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See AZI1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (7401087..7401951, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

used natural variation in Arabidopsis thaliana to study the role of zinc in regulating growth. We identify allelic variation of the systemic immunity gene AZI1 as a key for determining root growth responses to low zinc conditions
Title: Natural allelic variation of the AZI1 gene controls root growth under zinc-limiting condition.
The function of AZI1 in systemic acquired resistance of Arabidopsis was confirmed by investigation of the phenotypic features of wild-type Col-0, AZI1 T-DNA knockout and AZI1 overexpressing plants after infection with virulent and avirulent Pseudomonas syringae.
Title: Metabolomic analysis reveals the relationship between AZI1 and sugar signaling in systemic acquired resistance of Arabidopsis.
AZI1 is a partially secreted protein and a likely new member of the group of hydroxyproline-rich glycoproteins.
Title: Post-Translational Modification and Secretion of Azelaic Acid Induced 1 (AZI1), a Hybrid Proline-Rich Protein from Arabidopsis.
plastid targeting of AZI1 and AZI1 paralogs occurs through a mechanism that may enable/facilitate their roles in signal mobilization
Title: Arabidopsis AZI1 family proteins mediate signal mobilization for systemic defence priming.
AZI1 overexpression in the mpk3 genetic background partially alleviates the salt-hypersensitive phenotype of this mutant, but functional MPK3 appears to be required for the full extent of AZI1-conferred robustness.
Title: Salt stress in Arabidopsis: lipid transfer protein AZI1 and its control by mitogen-activated protein kinase MPK3.
AZI1 is involved in defense priming in systemic plant immunity and was down-regulated in leaves by biotic and abiotic stresses.
Title: Identification of genes involved in the response of Arabidopsis to simultaneous biotic and abiotic stresses.
The lipid transfer proteins AZI1 which is required for G3P- and azelaic acid-induced Systemic acquired resistance, is essential for G3P accumulation.
Title: A feedback regulatory loop between G3P and lipid transfer proteins DIR1 and AZI1 mediates azelaic-acid-induced systemic immunity.
AZI1 might be multifunctional and associated with cold tolerance of Arabidopsis.
Title: Cold-inducible expression of AZI1 and its function in improvement of freezing tolerance of Arabidopsis thaliana and Saccharomyces cerevisiae.
findings show that azelaic acid and AZI1 (At4g12470) are components of plant systemic immunity involved in priming defenses
Title: Priming in systemic plant immunity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_117317.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cold acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in induced systemic resistance	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within induced systemic resistance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within systemic acquired resistance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in plasmodesma	HDA more info	PubMed
located_in plasmodesma	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: azelaic acid induced 1

NP_192984.1

azelaic acid induced 1 (AZI1); FUNCTIONS IN: lipid binding; INVOLVED IN: systemic acquired resistance, defense response to fungus, lipid transport; LOCATED IN: endomembrane system; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Bifunctional inhibitor/plant lipid transfer protein/seed storage (InterPro:IPR016140), Plant lipid transfer protein/seed storage/trypsin-alpha amylase inhibitor (InterPro:IPR003612), Plant lipid transfer protein/hydrophobic protein, helical domain (InterPro:IPR013770); BEST Arabidopsis thaliana protein match is: Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein (TAIR:AT4G12490.1); Has 8822 Blast hits to 3488 proteins in 583 species: Archae - 14; Bacteria - 2048; Metazoa - 593; Fungi - 280; Plants - 3546; Viruses - 1040; Other Eukaryotes - 1301 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

7401087..7401951 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_117317.4 → NP_192984.1 azelaic acid induced 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_192984.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SU35

UniProtKB/TrEMBL

A0A178UVB8, A0A5S9XTD7

Conserved Domains (1) summary

cd01958
Location:75 → 160

HPS_like; Hydrophobic Protein from Soybean (HPS)-like subfamily; composed of proteins with similarity to HPS, a small hydrophobic protein with unknown function related to cereal-type alpha-amylase inhibitors and lipid transfer proteins. In addition to HPS, members ...