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    CLT2 CRT (chloroquine-resistance transporter)-like transporter 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828548, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLT2
    Official Full Name
    CRT (chloroquine-resistance transporter)-like transporter 2
    Primary source
    TAIR:AT4G24460
    Locus tag
    AT4G24460
    See related
    Araport:AT4G24460
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CRT (chloroquine-resistance transporter)-like transporter 2; T22A6.290; T22A6_290
    Summary
    Encodes one of the CRT-Like transporters (CLT1/AT5G19380, CLT2/AT4G24460, CLT3/AT5G12170). Required for glutathione homeostasis and stress responses. Mutants lacking these transporters are heavy metal-sensitive, glutathione(GSH)-deficient, and hypersensitive to Phytophthora infection.
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    Genomic context

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    See CLT2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (12642844..12645501)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene transcription initiation factor IIA gamma chain / TFIIA-gamma (TFIIA-S) Neighboring gene phosphoglucan, water dikinase Neighboring gene GATA-type zinc finger protein with TIFY domain-containing protein Neighboring gene Protein kinase superfamily protein Neighboring gene RAB geranylgeranyl transferase alpha subunit 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses. Maughan SC, et al. Proc Natl Acad Sci U S A, 2010 Feb 2. PMID 20080670, Free PMC Article
    2. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    4. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203891.1
    NM_001341676.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to oomycetes IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within glutathione transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CRT (chloroquine-resistance transporter)-like transporter 2
    NP_001190820.1
    • CRT (chloroquine-resistance transporter)-like transporter 2 (CLT2); CONTAINS InterPro DOMAIN/s: Chloroquine resistance transporter related (InterPro:IPR013936); BEST Arabidopsis thaliana protein match is: CRT (chloroquine-resistance transporter)-like transporter 3 (TAIR:AT5G12170.2).
    NP_194177.2
    • CRT (chloroquine-resistance transporter)-like transporter 2 (CLT2); INVOLVED IN: response to cadmium ion, defense response to oomycetes, glutathione transport; LOCATED IN: chloroplast, plastid; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Chloroquine resistance transporter related (InterPro:IPR013936); BEST Arabidopsis thaliana protein match is: CRT (chloroquine-resistance transporter)-like transporter 3 (TAIR:AT5G12170.2); Has 203 Blast hits to 201 proteins in 65 species: Archae - 2; Bacteria - 34; Metazoa - 4; Fungi - 0; Plants - 75; Viruses - 0; Other Eukaryotes - 88 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12642844..12645501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341675.1 → NP_001329790.1  CRT (chloroquine-resistance transporter)-like transporter 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8S9

    2. NM_118579.4 → NP_194177.2  CRT (chloroquine-resistance transporter)-like transporter 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194177.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1L4X0, Q84TI1, Q9STU9
      UniProtKB/TrEMBL
      A0A5S9XWC1
      Conserved Domains (1) summary
      cl23754
      Location:94 → 417
      EamA; EamA-like transporter family

    3. NM_001203891.1 → NP_001190820.1  CRT (chloroquine-resistance transporter)-like transporter 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190820.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1L4X0, Q84TI1, Q9STU9
      UniProtKB/TrEMBL
      A0A5S9XWC1
      Conserved Domains (1) summary
      cl23754
      Location:94 → 417
      EamA; EamA-like transporter family

    4. NM_001341676.1 → NP_001329789.1  CRT (chloroquine-resistance transporter)-like transporter 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8T5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1L4X0.1

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