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    Phosphorylase superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829636, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Phosphorylase superfamily protein
    Primary source
    TAIR:AT4G34840
    Locus tag
    AT4G34840
    See related
    Araport:AT4G34840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS METHYLTHIOADENOSINE NUCLEOSIDASE 2; ATMTAN2; ATMTN2; F11I11.80; F11I11_80; methylthioadenosine nucleosidase 2; METHYLTHIOADENOSINE NUCLEOSIDASE 2; MTAN2; MTN2
    Summary
    Encodes one of the 5'-methylthioadenosine nucleosidases (AT4G38800/MTN1; AT4G34840/MTN2). Double mutant, mtn1-1mtn2-1, retains approximately 14% of the MTN enzyme activity present in the wild type and displays a pleiotropic phenotype that includes altered vasculature and impaired fertility.
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    Genomic context

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    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (16606215..16608292)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene SAUR-like auxin-responsive protein family Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Chalcone and stilbene synthase family protein Neighboring gene Plant neutral invertase family protein Neighboring gene rotamase cyclophilin 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Recycling of methylthioadenosine is essential for normal vascular development and reproduction in Arabidopsis. Waduwara-Jayabahu I, et al. Plant Physiol, 2012 Apr. PMID 22345506, Free PMC Article
    2. Inhibition of 5'-methylthioadenosine metabolism in the Yang cycle alters polyamine levels, and impairs seedling growth and reproduction in Arabidopsis. Bürstenbinder K, et al. Plant J, 2010 Jun 1. PMID 20345605
    3. Biochemical and structural characterization of 5'-methylthioadenosine nucleosidases from Arabidopsis thaliana. Park EY, et al. Biochem Biophys Res Commun, 2009 Apr 17. PMID 19249293
    4. Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases. Siu KK, et al. J Mol Biol, 2008 Apr 18. PMID 18342331, Free PMC Article
    5. Calcineurin B-like 3 calcium sensor associates with and inhibits 5'-methylthioadenosine nucleosidase 2 in Arabidopsis. Ok SH, et al. Plant Sci, 2015 Sep. PMID 26259190

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtMTAN2 associated exclusively with CBL3.
      Title: Calcineurin B-like 3 calcium sensor associates with and inhibits 5'-methylthioadenosine nucleosidase 2 in Arabidopsis.
    2. MTA as a crucial metabolite that acts as a regulatory link between the Yang cycle and polyamine biosynthesis and identifies MTA nucleosidase as a crucial enzyme of the Yang cycle. [MTN2]
      Title: Inhibition of 5'-methylthioadenosine metabolism in the Yang cycle alters polyamine levels, and impairs seedling growth and reproduction in Arabidopsis.
    3. a structural comparison of AtMTAN2 performed with previously determined structures of AtMTAN1 and an E. coli homolog provides clues for the substrate specificity of MTA nucleosidases in A. thaliana.
      Title: Biochemical and structural characterization of 5'-methylthioadenosine nucleosidases from Arabidopsis thaliana.
    4. AtMTAN2 was characterized kinetically.
      Title: Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_119650.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenosylhomocysteine nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylthioadenosine nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methylthioadenosine nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylthioadenosine nucleosidase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-methionine salvage from methylthioadenosine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-methionine salvage from methylthioadenosine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phloem or xylem histogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within reproductive process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Phosphorylase superfamily protein
    NP_195210.2
    • Phosphorylase superfamily protein; CONTAINS InterPro DOMAIN/s: Nucleoside phosphorylase (InterPro:IPR000845), Nucleoside phosphorylase, family 1 (InterPro:IPR018017); BEST Arabidopsis thaliana protein match is: methylthioadenosine nucleosidase 1 (TAIR:AT4G38800.1); Has 2832 Blast hits to 2832 proteins in 1251 species: Archae - 0; Bacteria - 2704; Metazoa - 0; Fungi - 0; Plants - 81; Viruses - 0; Other Eukaryotes - 47 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      16606215..16608292
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342303.1 → NP_001329682.1  Phosphorylase superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8G4

    2. NM_001342305.1 → NP_001329685.1  Phosphorylase superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8H6
      Conserved Domains (1) summary
      PLN02584
      Location:1 → 204
      PLN02584; 5'-methylthioadenosine nucleosidase

    3. NM_001342304.1 → NP_001329684.1  Phosphorylase superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8G8
      Conserved Domains (1) summary
      cl00303
      Location:6 → 189
      PNP_UDP_1; Phosphorylase superfamily

    4. NM_001342306.1 → NP_001329683.1  Phosphorylase superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8G8
      Conserved Domains (1) summary
      cl00303
      Location:6 → 189
      PNP_UDP_1; Phosphorylase superfamily

    5. NM_119650.4 → NP_195210.2  Phosphorylase superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195210.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7XA67, Q9SW50
      UniProtKB/TrEMBL
      A0A178V169, A0A5S9XYP6
      Conserved Domains (1) summary
      PLN02584
      Location:6 → 254
      PLN02584; 5'-methylthioadenosine nucleosidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7XA67.1

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