U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    IMPL2 inositol monophosphatase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830067, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    IMPL2
    Official Full Name
    inositol monophosphatase family protein
    Primary source
    TAIR:AT4G39120
    Locus tag
    AT4G39120
    See related
    Araport:AT4G39120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HISN7; HISTIDINE BIOSYNTHESIS 7; myo-inositol monophosphatase like 2; T22F8.20; T22F8_20
    Summary
    Encodes a chloroplast-localized member of the myo-inositol monophosphatase family, IMPL2 (myo-Inositol monophosphatase like 2) that seems to have multiple enzymatic activities. It contributes to histidine biosynthesis based on it histidinol-phosphate phosphatase activity. In addition, the protein can act as an inositol monophosphatase and an L-galactose-1-phosphate phosphatase in vitro.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See IMPL2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Sequence:
    Chromosome: 4; NC_003075.7 (18225297..18227988, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene Malectin/receptor-like protein kinase family protein Neighboring gene Dehydrin family protein Neighboring gene RING/U-box superfamily protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression and functions of myo-inositol monophosphatase family genes in seed development of Arabidopsis. Sato Y, et al. J Plant Res, 2011 May. PMID 20960216
    2. The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase. Petersen LN, et al. Plant Physiol, 2010 Mar. PMID 20023146, Free PMC Article
    3. VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants. Torabinejad J, et al. Plant Physiol, 2009 Jun. PMID 19339506, Free PMC Article
    4. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The IMPL2 mutant has an embryo lethal phenotype that could be partially rescued by histidine.
      Title: Expression and functions of myo-inositol monophosphatase family genes in seed development of Arabidopsis.
    2. IMPL2 catalyzes the dephosphorylation of histidinol-P to histidinol, completing the His biosynthetic pathway in plants.
      Title: The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase.
    3. IMPL2 encodes a functional histidinol-phosphate phosphatase (HISN7) as evidenced by complementation of a Streptomyces coelicolor hisN mutant and analysis of impl2 T-DNA insertion lines
      Title: The missing link in plant histidine biosynthesis: Arabidopsis myoinositol monophosphatase-like2 encodes a functional histidinol-phosphate phosphatase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help
    NM_001342523.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-galactose-1-phosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histidinol-phosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables histidinol-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables inositol monophosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-histidine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    inositol monophosphatase family protein
    NP_001320164.1
    • myo-inositol monophosphatase like 2 (IMPL2); FUNCTIONS IN: histidinol-phosphatase activity, 3'(2'),5'-bisphosphate nucleotidase activity, L-galactose-1-phosphate phosphatase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1(or 4)-monophosphatase activity; INVOLVED IN: sulfur metabolic process, histidine biosynthetic process; LOCATED IN: chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Histidinol-phosphate phosphatase, putative, inositol monophosphatase (InterPro:IPR011809), Inositol monophosphatase (InterPro:IPR000760), Inositol monophosphatase, metal-binding site (InterPro:IPR020583); BEST Arabidopsis thaliana protein match is: Inositol monophosphatase family protein (TAIR:AT3G02870.1); Has 15134 Blast hits to 15130 proteins in 2267 species: Archae - 157; Bacteria - 8374; Metazoa - 557; Fungi - 304; Plants - 238; Viruses - 0; Other Eukaryotes - 5504 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      18225297..18227988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120072.5 → NP_195623.3  inositol monophosphatase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195623.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9Y092, A0A654FWV2
      Conserved Domains (1) summary
      PLN02911
      Location:80 → 375
      PLN02911; inositol-phosphate phosphatase

    2. NM_001342523.1 → NP_001320164.1  inositol monophosphatase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A1P8B6U8, F4JV95, Q67Y38, Q6NPM8, Q9T021
      UniProtKB/TrEMBL
      A0A178V0S3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NPM8.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.