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    BCAT3 branched-chain aminotransferase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824130, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BCAT3
    Official Full Name
    branched-chain aminotransferase 3
    Primary source
    TAIR:AT3G49680
    Locus tag
    AT3G49680
    See related
    Araport:AT3G49680
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATBCAT-3; branched-chain aminotransferase 3
    Summary
    Encodes a chloroplast branched-chain amino acid aminotransferase. Complements the yeast leu/iso-leu/val auxotrophy mutant.
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    Genomic context

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    See BCAT3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (18422542..18425758)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene ncRNA Neighboring gene Leucine-rich receptor-like protein kinase family protein Neighboring gene myb domain protein 84 Neighboring gene 1-aminocyclopropane-1-carboxylate synthase 9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis branched-chain aminotransferase 3 functions in both amino acid and glucosinolate biosynthesis. Knill T, et al. Plant Physiol, 2008 Mar. PMID 18162591, Free PMC Article
    2. Arabidopsis and maize RidA proteins preempt reactive enamine/imine damage to branched-chain amino acid biosynthesis in plastids. Niehaus TD, et al. Plant Cell, 2014 Jul. PMID 25070638, Free PMC Article
    3. The branched-chain amino acid transaminase gene family in Arabidopsis encodes plastid and mitochondrial proteins. Diebold R, et al. Plant Physiol, 2002 Jun. PMID 12068099, Free PMC Article
    4. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202
    5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. most likely catalyzes the terminal steps in the chain elongation process leading to short-chain glucosinolates
      Title: Arabidopsis branched-chain aminotransferase 3 functions in both amino acid and glucosinolate biosynthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001125330.1
    NM_114828.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-isoleucine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-leucine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables L-valine-2-oxoglutarate transaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables branched-chain-amino-acid transaminase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-valine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    branched-chain aminotransferase 3
    NP_001118802.1
    • branched-chain aminotransferase 3 (BCAT3); FUNCTIONS IN: branched-chain-amino-acid transaminase activity, catalytic activity; INVOLVED IN: branched chain family amino acid metabolic process, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aminotransferase, class IV (InterPro:IPR001544), Aminotransferase, class IV, conserved site (InterPro:IPR018300), Branched-chain amino acid aminotransferase II (InterPro:IPR005786); BEST Arabidopsis thaliana protein match is: branched-chain amino acid aminotransferase 5 / branched-chain amino acid transaminase 5 (BCAT5) (TAIR:AT5G65780.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_566923.1
    • branched-chain aminotransferase 3 (BCAT3); FUNCTIONS IN: branched-chain-amino-acid transaminase activity, catalytic activity; INVOLVED IN: branched chain family amino acid metabolic process, metabolic process; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aminotransferase, class IV (InterPro:IPR001544), Aminotransferase, class IV, conserved site (InterPro:IPR018300), Branched-chain amino acid aminotransferase II (InterPro:IPR005786); BEST Arabidopsis thaliana protein match is: branched-chain amino acid aminotransferase 5 / branched-chain amino acid transaminase 5 (BCAT5) (TAIR:AT5G65780.1); Has 12479 Blast hits to 12479 proteins in 2523 species: Archae - 154; Bacteria - 7638; Metazoa - 266; Fungi - 416; Plants - 252; Viruses - 0; Other Eukaryotes - 3753 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18422542..18425758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114828.6 → NP_566923.1  branched-chain aminotransferase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566923.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LAT6, Q9M2Z0, Q9M401
      UniProtKB/TrEMBL
      A0A178VH13, A0A654FG91
      Conserved Domains (1) summary
      PLN02782
      Location:13 → 413
      PLN02782; Branched-chain amino acid aminotransferase

    2. NM_001125330.1 → NP_001118802.1  branched-chain aminotransferase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VH13, B3H658
      Conserved Domains (2) summary
      PLN02782
      Location:13 → 411
      PLN02782; Branched-chain amino acid aminotransferase
      cd01557
      Location:115 → 398
      BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M401.1

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