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    ABCG37 pleiotropic drug resistance 9 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824516, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ABCG37
    Official Full Name
    pleiotropic drug resistance 9
    Primary source
    TAIR:AT3G53480
    Locus tag
    AT3G53480
    See related
    Araport:AT3G53480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATP-binding cassette G37; ATPDR9; PDR9; PIS1; pleiotropic drug resistance 9; PLEIOTROPIC DRUG RESISTANCE 9; polar auxin transport inhibitor sensitive 1
    Summary
    Negative regulator of auxin polar transport inhibitors. ABCG37 regulates auxin distribution and homeostasis in roots by excluding IBA from the root apex, but does not act directly in basipetal transport. ABCG37 and ABCG36 act redundantly at outermost root plasma membranes and, transport IBA out of the cells. Also involved in root transmembrane secretion of fluorescent phenolics involved in Fe uptake.
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    Genomic context

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    See ABCG37 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    23
    Sequence:
    Chromosome: 3; NC_003074.8 (19825267..19831880)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene chloroplast RNA-binding protein 29 Neighboring gene 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Neighboring gene valine-tRNA ligase Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein with retrovirus zinc finger-like domain-containing protein Neighboring gene ABC-2 type transporter family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of the ABCG37 transporter in secretion of scopoletin and derivatives by Arabidopsis roots in response to iron deficiency. Fourcroy P, et al. New Phytol, 2014 Jan. PMID 24015802
    2. PDR9 allelic variation and MYB63 modulate nutrient-dependent coumarin homeostasis in Arabidopsis. DeLoose M, et al. Plant J, 2024 Mar. PMID 38361338
    3. ATP binding cassette proteins ABCG37 and ABCG33 function as potassium-independent cesium uptake carriers in Arabidopsis roots. Ashraf MA, et al. Mol Plant, 2021 Apr 5. PMID 33588076
    4. Arabidopsis Transporter ABCG37/PDR9 contributes primarily highly oxygenated Coumarins to Root Exudation. Ziegler J, et al. Sci Rep, 2017 Jun 16. PMID 28623273, Free PMC Article
    5. Mutually exclusive alterations in secondary metabolism are critical for the uptake of insoluble iron compounds by Arabidopsis and Medicago truncatula. Rodríguez-Celma J, et al. Plant Physiol, 2013 Jul. PMID 23735511, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDR9 allelic variation and MYB63 modulate nutrient-dependent coumarin homeostasis in Arabidopsis.
      Title: PDR9 allelic variation and MYB63 modulate nutrient-dependent coumarin homeostasis in Arabidopsis.
    2. ATP binding cassette proteins ABCG37 and ABCG33 function as potassium-independent cesium uptake carriers in Arabidopsis roots.
      Title: ATP binding cassette proteins ABCG37 and ABCG33 function as potassium-independent cesium uptake carriers in Arabidopsis roots.
    3. role of ABCG37, IRT1 and FRO2 in root Fe2+ transport systems
      Title: Facilitated Fe Nutrition by Phenolic Compounds Excreted by the Arabidopsis ABCG37/PDR9 Transporter Requires the IRT1/FRO2 High-Affinity Root Fe(2+) Transport System.
    4. ABCG37 encodes the pleiotropic drug resistance transporter that transports a range of synthetic auxinic compounds as well as the endogenous auxin precursor indole-3-butyric acid (IBA), but not free indole-3-acetic acid.
      Title: Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid.
    5. characterization of the PDR9 gene; 2,4-D, but not indole-3-acetic acid transport is affected by mutations in pdr9, suggesting that the PDR9 transporter specifically effluxes 2,4-D out of plant cells without affecting endogenous auxin transport
      Title: A gain-of-function mutation in the Arabidopsis pleiotropic drug resistance transporter PDR9 confers resistance to auxinic herbicides.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115208.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ATPase-coupled transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables auxin efflux transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables auxin efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 2,4-dichlorophenoxyacetic acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within auxin polar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular detoxification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to indolebutyric acid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in coumarin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in export from cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within_negative_effect response to cesium ion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to iron ion starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to iron ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    pleiotropic drug resistance 9
    NP_190916.1
    • pleiotropic drug resistance 9 (PDR9); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of substances, transporter activity; INVOLVED IN: cellular response to indolebutyric acid stimulus, drug transmembrane transport, root development, auxin polar transport; LOCATED IN: plasma membrane; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: 4 anthesis; CONTAINS InterPro DOMAIN/s: ATPase, AAA+ type, core (InterPro:IPR003593), ABC transporter-like (InterPro:IPR003439), Plant PDR ABC transporter associated (InterPro:IPR013581), ABC-2 type transporter (InterPro:IPR013525); BEST Arabidopsis thaliana protein match is: pleiotropic drug resistance 5 (TAIR:AT2G37280.1); Has 430532 Blast hits to 296745 proteins in 4078 species: Archae - 8262; Bacteria - 349677; Metazoa - 9969; Fungi - 7006; Plants - 6279; Viruses - 7; Other Eukaryotes - 49332 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19825267..19831880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115208.4 → NP_190916.1  pleiotropic drug resistance 9 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LFH0
      UniProtKB/TrEMBL
      A0A178VF56, A0A5S9XKH6, A0A654FFH7
      Conserved Domains (6) summary
      cd03232
      Location:847 → 1085
      ABCG_PDR_domain2; Second domain of the pleiotropic drug resistance-like (PDR) subfamily G of ATP-binding cassette transporters
      cd03233
      Location:186 → 429
      ABCG_PDR_domain1; First domain of the pleiotropic drug resistance-like subfamily G of ATP-binding cassette transporters
      PLN03140
      Location:54 → 1450
      PLN03140; ABC transporter G family member; Provisional
      pfam01061
      Location:1180 → 1387
      ABC2_membrane; ABC-2 type transporter
      pfam08370
      Location:742 → 804
      PDR_assoc; Plant PDR ABC transporter associated
      pfam14510
      Location:89 → 167
      ABC_trans_N; ABC-transporter extracellular N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LFH0.1

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