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    VAMP727 vesicle-associated membrane protein 727 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824597, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VAMP727
    Official Full Name
    vesicle-associated membrane protein 727
    Primary source
    TAIR:AT3G54300
    Locus tag
    AT3G54300
    See related
    Araport:AT3G54300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATVAMP727; vesicle-associated membrane protein 727
    Summary
    Encodes a member of Synaptobrevin -like protein family. VAMP727 is a R-SNARE and interacts with SYP22/VTI11/SYP51. It is required for trafficking of storage proteins to the protein storage vacuoles (PSV) and also for PSV organization and biogenesis. Loss of function mutations have no phenotype but double mutants with SYP22 are embryo lethal.
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    Genomic context

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    See VAMP727 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (20108207..20110883, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ROOT GROWTH DEFECTIVE 3 Neighboring gene hemerythrin HHE cation-binding domain protein Neighboring gene DNA-directed RNA polymerase subunit alpha Neighboring gene Integrase-type DNA-binding superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SNARE proteins SYP22 and VAMP727 negatively regulate plant defense. Zhu XF, et al. Plant Signal Behav, 2019. PMID 31025584, Free PMC Article
    2. A SNARE complex unique to seed plants is required for protein storage vacuole biogenesis and seed development of Arabidopsis thaliana. Ebine K, et al. Plant Cell, 2008 Nov. PMID 18984676, Free PMC Article
    3. SYP22 and VAMP727 regulate BRI1 plasma membrane targeting to control plant growth in Arabidopsis. Zhang L, et al. New Phytol, 2019 Aug. PMID 30802967
    4. The Arabidopsis R-SNARE VAMP721 Interacts with KAT1 and KC1 K+ Channels to Moderate K+ Current at the Plasma Membrane. Zhang B, et al. Plant Cell, 2015 Jun. PMID 26002867, Free PMC Article
    5. The longin domain regulates subcellular targeting of VAMP7 in Arabidopsis thaliana. Uemura T, et al. FEBS Lett, 2005 May 23. PMID 15876431

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VAMP727-SYP22 SNARE complexes regulate plant defense might be via control of abundances of BRI1 on the plasma membrane.
      Title: SNARE proteins SYP22 and VAMP727 negatively regulate plant defense.
    2. Q-SNARE SYP22 and R-SNARE VAMP727 mediate the BRI trafficking to plasma membrane.
      Title: SYP22 and VAMP727 regulate BRI1 plasma membrane targeting to control plant growth in Arabidopsis.
    3. VAMP727 is a multicopy suppressor of SYP22, and helps mediate the fusion between the prevacuolar compartment and the vacuole.
      Title: A SNARE complex unique to seed plants is required for protein storage vacuole biogenesis and seed development of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084814.2
    NM_001339657.1
    NM_115290.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vacuole organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CORVET complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SNARE complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vesicle-associated membrane protein 727
    NP_001078283.1
    • vesicle-associated membrane protein 727 (VAMP727); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: vacuole organization, protein targeting to vacuole; LOCATED IN: endosome, SNARE complex, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Longin (InterPro:IPR010908), Longin-like (InterPro:IPR011012), Synaptobrevin (InterPro:IPR001388); BEST Arabidopsis thaliana protein match is: vesicle-associated membrane protein 726 (TAIR:AT1G04760.1); Has 2397 Blast hits to 2395 proteins in 262 species: Archae - 0; Bacteria - 0; Metazoa - 970; Fungi - 430; Plants - 618; Viruses - 0; Other Eukaryotes - 379 (source: NCBI BLink).
    NP_190998.1
    • vesicle-associated membrane protein 727 (VAMP727); FUNCTIONS IN: molecular_function unknown; INVOLVED IN: vacuole organization, protein targeting to vacuole; LOCATED IN: endosome, SNARE complex, membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Longin (InterPro:IPR010908), Longin-like (InterPro:IPR011012), Synaptobrevin (InterPro:IPR001388); BEST Arabidopsis thaliana protein match is: vesicle-associated membrane protein 726 (TAIR:AT1G04760.1); Has 2397 Blast hits to 2395 proteins in 262 species: Archae - 0; Bacteria - 0; Metazoa - 970; Fungi - 430; Plants - 618; Viruses - 0; Other Eukaryotes - 379 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20108207..20110883 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115290.5 → NP_190998.1  vesicle-associated membrane protein 727 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190998.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XE0, Q9M376
      UniProtKB/TrEMBL
      A0A178VIG0, A0A5S9XKU3
      Conserved Domains (2) summary
      cd14824
      Location:7 → 140
      Longin; longin domain
      pfam00957
      Location:146 → 234
      Synaptobrevin

    2. NM_001339657.1 → NP_001326058.1  vesicle-associated membrane protein 727 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XE0, Q9M376
      UniProtKB/TrEMBL
      A0A178VIG0, A0A5S9XKU3
      Conserved Domains (2) summary
      cd14824
      Location:7 → 140
      Longin; longin domain
      pfam00957
      Location:146 → 234
      Synaptobrevin

    3. NM_001084814.2 → NP_001078283.1  vesicle-associated membrane protein 727 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078283.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q53XE0, Q9M376
      UniProtKB/TrEMBL
      A0A178VIG0, A0A5S9XKU3
      Conserved Domains (2) summary
      cd14824
      Location:7 → 140
      Longin; longin domain
      pfam00957
      Location:146 → 234
      Synaptobrevin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M376.1

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