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    AGL18 AGAMOUS-like 18 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824906, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGL18
    Official Full Name
    AGAMOUS-like 18
    Primary source
    TAIR:AT3G57390
    Locus tag
    AT3G57390
    See related
    Araport:AT3G57390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AGAMOUS-like 18
    Summary
    encodes a MADS-box containing protein likely to be a transcription factor that is expressed in endosperm and developing gametophytes. The protein sequence is most similar to that of AGL15, which is expressed in developing embryos.
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    Genomic context

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    See AGL18 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (21233472..21235978)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene tRNA-splicing endonuclease subunit Neighboring gene Cyclin family protein Neighboring gene Glycosyltransferase family 61 protein Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The MADS-domain factor AGAMOUS-Like18 promotes somatic embryogenesis. Paul P, et al. Plant Physiol, 2022 Mar 4. PMID 34850203, Free PMC Article
    2. Expression of the floral repressor miRNA156 is positively regulated by the AGAMOUS-like proteins AGL15 and AGL18. Serivichyaswat P, et al. Mol Cells, 2015 Mar. PMID 25666346, Free PMC Article
    3. The MADS domain factors AGL15 and AGL18 act redundantly as repressors of the floral transition in Arabidopsis. Adamczyk BJ, et al. Plant J, 2007 Jun. PMID 17521410
    4. MADS-box gene evolution beyond flowers: expression in pollen, endosperm, guard cells, roots and trichomes. Alvarez-Buylla ER, et al. Plant J, 2000 Nov. PMID 11115127
    5. The MADS-Domain Factors AGAMOUS-LIKE15 and AGAMOUS-LIKE18, along with SHORT VEGETATIVE PHASE and AGAMOUS-LIKE24, Are Necessary to Block Floral Gene Expression during the Vegetative Phase. Fernandez DE, et al. Plant Physiol, 2014 Aug. PMID 24948837, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AGL15 and AGL18 may form a complex along with other proteins, and bind to the CArG motifs of the promoters of MIR156 to activate the MIR156 expression.
      Title: Expression of the floral repressor miRNA156 is positively regulated by the AGAMOUS-like proteins AGL15 and AGL18.
    2. Flowering time is determined by the additive effect of multiple MADS domain floral repressors, with important contributions from AGL15 and AGL18.
      Title: The MADS domain factors AGL15 and AGL18 act redundantly as repressors of the floral transition in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001339857.1
    NM_115599.4
    NM_202721.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of short-day photoperiodism, flowering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    AGAMOUS-like 18
    NP_191298.1
    • AGAMOUS-like 18 (AGL18); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100), Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: AGAMOUS-like 15 (TAIR:AT5G13790.1); Has 6796 Blast hits to 6793 proteins in 870 species: Archae - 0; Bacteria - 0; Metazoa - 633; Fungi - 312; Plants - 5770; Viruses - 0; Other Eukaryotes - 81 (source: NCBI BLink).
    NP_974450.1
    • AGAMOUS-like 18 (AGL18); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity; INVOLVED IN: regulation of transcription, DNA-dependent; LOCATED IN: nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Transcription factor, K-box (InterPro:IPR002487); BEST Arabidopsis thaliana protein match is: AGAMOUS-like 15 (TAIR:AT5G13790.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21233472..21235978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115599.4 → NP_191298.1  AGAMOUS-like 18 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191298.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1ECG0, Q570M9, Q8LAS6, Q9M2K8
      UniProtKB/TrEMBL
      A0A178VAT6, A0A5S9XMB6
      Conserved Domains (2) summary
      cd00265
      Location:2 → 75
      MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
      pfam01486
      Location:94 → 179
      K-box; K-box region

    2. NM_001339857.1 → NP_001326798.1  AGAMOUS-like 18 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQD5

    3. NM_202721.1 → NP_974450.1  AGAMOUS-like 18 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974450.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M2K8
      Conserved Domains (1) summary
      pfam01486
      Location:41 → 116
      K-box; K-box region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M2K8.1

    Gene LinkOut

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