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    PRT6 proteolysis 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830916, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PRT6
    Official Full Name
    proteolysis 6
    Primary source
    TAIR:AT5G02310
    Locus tag
    AT5G02310
    See related
    Araport:AT5G02310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT5G02300; proteolysis 6; T1E22.70; T1E22_70
    Summary
    Encodes PROTEOLYSIS6 (PRT6), a component of the N-end rule pathway that targets protein degradation through the identity of the amino-terminal residue of specific protein substrates. Another component of the N-end rule pathway is arginyl-tRNA:protein arginyltransferase (ATE). Arabidopsis contains two ATE genes: At5g05700/ATE1, At3g11240/ATE2. PRT6 and ATE were shown to regulate seed after-ripening, seedling sugar sensitivity, seedling lipid breakdown, and abscisic acid (ABA) sensitivity of germination.
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    Genomic context

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    See PRT6 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    18
    Sequence:
    Chromosome: 5; NC_003076.8 (473868..482942)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene non-intrinsic ABC protein 9 Neighboring gene SNARE-like superfamily protein Neighboring gene Protein kinase superfamily protein Neighboring gene myb domain protein 3r-5 Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PRT6/At5g02310 encodes an Arabidopsis ubiquitin ligase of the N-end rule pathway with arginine specificity and is not the CER3 locus. Garzón M, et al. FEBS Lett, 2007 Jul 10. PMID 17572409
    2. NIN-like protein7 and PROTEOLYSIS6 functional interaction enhances tolerance to sucrose, ABA, and submergence. Castillo MC, et al. Plant Physiol, 2021 Dec 4. PMID 34618055, Free PMC Article
    3. The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development. Labandera AM, et al. New Phytol, 2021 Jan. PMID 32043277, Free PMC Article
    4. Distinct branches of the N-end rule pathway modulate the plant immune response. Vicente J, et al. New Phytol, 2019 Jan. PMID 30117535
    5. The CER3 wax biosynthetic gene from Arabidopsis thaliana is allelic to WAX2/YRE/FLP1. Rowland O, et al. FEBS Lett, 2007 Jul 24. PMID 17624331

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NIN-like protein7 and PROTEOLYSIS6 functional interaction enhances tolerance to sucrose, ABA, and submergence.
      Title: NIN-like protein7 and PROTEOLYSIS6 functional interaction enhances tolerance to sucrose, ABA, and submergence.
    2. The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development.
      Title: The PRT6 N-degron pathway restricts VERNALIZATION 2 to endogenous hypoxic niches to modulate plant development.
    3. PRT6 control of germination and establishment, as exemplified by ABA and sugar sensitivity, as well as storage oil mobilization, occurs at least in part via transcription factors ABI3 and ABI5.
      Title: The N-end rule pathway promotes seed germination and establishment through removal of ABA sensitivity in Arabidopsis.
    4. At5g02310 is not identical to CER3, a gene involved in establishment of a protective surface wax layer. At5g02310 has therefore been re-designated PROTEOLYSIS 6 (PRT6), in accordance with its ubiquitin ligase function.
      Title: PRT6/At5g02310 encodes an Arabidopsis ubiquitin ligase of the N-end rule pathway with arginine specificity and is not the CER3 locus.
    5. CER3 is not At5g02310 and instead corresponds to WAX2/YRE/FLP1 (At5g57800), a gene of unknown function required for wax biosynthesis
      Title: The CER3 wax biosynthetic gene from Arabidopsis thaliana is allelic to WAX2/YRE/FLP1.
    Submit: New GeneRIF Correction

    General gene information

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    NM_001342651.1
    NM_120309.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of lipid catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in wax biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    proteolysis 6
    NP_001318457.1
    • proteolysis 6 (PRT6); CONTAINS InterPro DOMAIN/s: Zinc finger, N-recognin, metazoa (InterPro:IPR013993), Zinc finger, N-recognin (InterPro:IPR003126); Has 1893 Blast hits to 778 proteins in 199 species: Archae - 0; Bacteria - 0; Metazoa - 939; Fungi - 577; Plants - 100; Viruses - 0; Other Eukaryotes - 277 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      473868..482942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001342652.1 → NP_001331954.1  proteolysis 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UMF0, A0A1P8BFH3

    2. NM_001342651.1 → NP_001318457.1  proteolysis 6 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KCC2, Q96248, Q9LZ94, Q9LZ95
      UniProtKB/TrEMBL
      A0A178UMF0

    3. NM_120309.2 → NP_195851.2  proteolysis 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195851.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KCC2, Q96248, Q9LZ94, Q9LZ95
      UniProtKB/TrEMBL
      A0A178UMF0
      Conserved Domains (1) summary
      pfam02207
      Location:121 → 187
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4KCC2.1

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