2-Cys Prx B 2-cysteine peroxiredoxin B [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: 2-Cys Prx B
Official Full Name: 2-cysteine peroxiredoxin B
Primary source: TAIR:AT5G06290
Locus tag: AT5G06290
See related: Araport:AT5G06290
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 2-CYS PEROXIREDOXIN B; 2-cysteine peroxiredoxin B; 2CPB
Summary: Encodes a 2-Cys peroxiredoxin (2-Cys PrxB) that contains two catalytic Cys residues.
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Genomic context

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See 2-Cys Prx B in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 7

Sequence:: Chromosome: 5; NC_003076.8 (1919080..1921425)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

2-cysteine peroxiredoxins
Title: Redox-control of chlorophyll biosynthesis mainly depends on thioredoxins.
The oligomerization status of plant 2-Cys PRX does not exhibit important variation and is not tightly linked to the protein redox status upon physiologically relevant environmental constraints.
Title: Physiological relevance of plant 2-Cys peroxiredoxin overoxidation level and oligomerization status.
interaction of chloroplast 2-Cys peroxiredoxin with NADPH-thioredoxin reductase C (NTRC) and thioredoxin x
Title: Molecular recognition in the interaction of chloroplast 2-Cys peroxiredoxin with NADPH-thioredoxin reductase C (NTRC) and thioredoxin x.
2-cysteine peroxoredoxins from Homo sapiens, Arabidopsis thaliana, and Pisum sativum as well as a carboxy-terminally truncated variant were subjected to isothermal titration calorimetry analysis.
Title: Thermodynamics of the dimer-decamer transition of reduced human and plant 2-cys peroxiredoxin.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001342875.1

Supported by ESTs:

NM_120712.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables peroxidase activity	IDA Inferred from Direct Assay more info
enables peroxiredoxin activity	IDA Inferred from Direct Assay more info	PubMed
enables thioredoxin-dependent peroxiredoxin activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell redox homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in apoplast	HDA more info	PubMed
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast stroma	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in stromule	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 2-cysteine peroxiredoxin B

NP_568166.1

2-cysteine peroxiredoxin B (2-Cys Prx B); FUNCTIONS IN: peroxiredoxin activity, antioxidant activity; INVOLVED IN: response to cold, defense response to bacterium; LOCATED IN: apoplast, stromule, chloroplast stroma, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peroxiredoxin, C-terminal (InterPro:IPR019479), Thioredoxin fold (InterPro:IPR012335), Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen (InterPro:IPR000866), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: Thioredoxin superfamily protein (TAIR:AT3G11630.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

1919080..1921425

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_120712.4 → NP_568166.1 2-cysteine peroxiredoxin B [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568166.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9C5R8, Q9FED5, Q9FNH9

UniProtKB/TrEMBL

A0A178ULP1, A0A654FYS1

Conserved Domains (1) summary

cd03015
Location:82 → 255

PRX_Typ2cys; Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides. ...
NM_001342875.1 → NP_001331225.1 2-cysteine peroxiredoxin B [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178ULP1, A0A1P8BD74