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    THO1 nuclear matrix protein-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830846, updated on 18-Sep-2024

    Summary

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    Official Symbol
    THO1
    Official Full Name
    nuclear matrix protein-like protein
    Primary source
    TAIR:AT5G09860
    Locus tag
    AT5G09860
    See related
    Araport:AT5G09860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtHPR1; AtTHO1; HPR1; MYH9.7; MYH9_7
    Summary
    Encodes a component of the putative Arabidopsis THO/TREX complex: THO1 or HPR1 (At5g09860), THO2 (At1g24706), THO3 or TEX1 (At5g56130), THO5 (At5g42920, At1g45233), THO6 (At2g19430), and THO7 (At5g16790, At3g02950). THO/TREX complexes in animals have been implicated in the transport of mRNA precursors. Mutants of THO3/TEX1, THO1, THO6 accumulate reduced amount of small interfering (si)RNA, suggesting a role of the putative Arabidopsis THO/TREX in siRNA biosynthesis.
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    Genomic context

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    See THO1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    20
    Sequence:
    Chromosome: 5; NC_003076.8 (3066562..3070989)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Putative endonuclease or glycosyl hydrolase Neighboring gene Transcription elongation factor (TFIIS) family protein Neighboring gene cellulose synthase 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Accumulation of the coumarin scopolin under abiotic stress conditions is mediated by the Arabidopsis thaliana THO/TREX complex. Döll S, et al. Plant J, 2018 Feb. PMID 29222952
    2. The THO/TREX Complex Active in miRNA Biogenesis Negatively Regulates Root-Associated Acid Phosphatase Activity Induced by Phosphate Starvation. Tao S, et al. Plant Physiol, 2016 Aug. PMID 27329222, Free PMC Article
    3. HPR1, a component of the THO/TREX complex, plays an important role in disease resistance and senescence in Arabidopsis. Pan H, et al. Plant J, 2012 Mar. PMID 22035198
    4. Characterization of EMU, the Arabidopsis homolog of the yeast THO complex member HPR1. Furumizu C, et al. RNA, 2010 Sep. PMID 20668032, Free PMC Article
    5. The THO/TREX Complex Active in Alternative Splicing Mediates Plant Responses to Salicylic Acid and Jasmonic Acid. Sun N, et al. Int J Mol Sci, 2021 Nov 11. PMID 34830079, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The THO/TREX Complex Active in Alternative Splicing Mediates Plant Responses to Salicylic Acid and Jasmonic Acid.
      Title: The THO/TREX Complex Active in Alternative Splicing Mediates Plant Responses to Salicylic Acid and Jasmonic Acid.
    2. THO1 is required for scopolin accumulation in roots induced by sucrose.THO1 is part of the THO/TREX complex, which contributes to RNA silencing, supposedly by trafficking precursors of small RNAs.
      Title: Accumulation of the coumarin scopolin under abiotic stress conditions is mediated by the Arabidopsis thaliana THO/TREX complex.
    3. THO/TREX complex is involved in mRNA export and miRNA biogenesis in Arabidopsis. THO/TREX complex negatively regulates root-associated APase activity by suppressing ethylene signaling. [AtTHO1]
      Title: The THO/TREX Complex Active in miRNA Biogenesis Negatively Regulates Root-Associated Acid Phosphatase Activity Induced by Phosphate Starvation.
    4. Study identified the role of LON2 protease and the photorespiratory enzyme HPR1 in drought resistance.
      Title: Using Co-Expression Analysis and Stress-Based Screens to Uncover Arabidopsis Peroxisomal Proteins Involved in Drought Response.
    5. Gene expression involved in ethylene signaling suppression was not reduced by the hpr1-5 mutation, which indicates selectivity of HPR1 for RTE1 expression affecting the consequent ethylene response. [HPR1]
      Title: HYPER RECOMBINATION1 of the THO/TREX complex plays a role in controlling transcription of the REVERSION-TO-ETHYLENE SENSITIVITY1 gene in Arabidopsis.
    6. HPR1 encodes a putative component of the THO/TREX complex that localizes to the nucleus and plays an important role in plant innate immunity.
      Title: HPR1, a component of the THO/TREX complex, plays an important role in disease resistance and senescence in Arabidopsis.
    7. HPR1 and TEX1 participate in the trafficking of siRNA precursors to the ARGONAUTE catalytic center.
      Title: The conserved RNA trafficking proteins HPR1 and TEX1 are involved in the production of endogenous and exogenous small interfering RNA in Arabidopsis.
    8. Study identified and characterized a mutant gene named erecta mRNA under-expressed (emu)at At5g09860 that leads to the defective mRNA accumulation of ERECTA, a developmental regulator in the model plant Arabidopsis thaliana.
      Title: Characterization of EMU, the Arabidopsis homolog of the yeast THO complex member HPR1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203340.2
    NM_121023.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ethylene-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ta-siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of THO complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nuclear matrix protein-like protein
    NP_001190269.1
    • THO1; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: production of ta-siRNAs involved in RNA interference, gene silencing by RNA; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: THO complex, subunit THOC1 (InterPro:IPR021861).
    NP_568219.1
    • THO1; CONTAINS InterPro DOMAIN/s: THO complex, subunit THOC1 (InterPro:IPR021861); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3066562..3070989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203340.2 → NP_001190269.1  nuclear matrix protein-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190269.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UIV4, A0A7G2F9K6, F4KFC9
      Conserved Domains (1) summary
      pfam11957
      Location:87 → 514
      efThoc1; THO complex subunit 1 transcription elongation factor

    2. NM_121023.4 → NP_568219.1  nuclear matrix protein-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568219.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8H134, Q93VM9, Q9FIC0
      UniProtKB/TrEMBL
      A0A178UJY8, A0A5S9Y2U1, A0A7G2F709
      Conserved Domains (1) summary
      pfam11957
      Location:87 → 515
      efThoc1; THO complex subunit 1 transcription elongation factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q93VM9.1

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