TTG1 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TTG1
Official Full Name: Transducin/WD40 repeat-like superfamily protein
Primary source: TAIR:AT5G24520
Locus tag: AT5G24520
See related: Araport:AT5G24520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATTTG1; K18P6.4; K18P6_4; TRANSPARENT TESTA GLABRA 1; TTG; UNARMED 23; URM23
Summary: Required for the accumulation of purple anthocyanins in leaves and stems. Involved in trichome and root hair development. Controls epidermal cell fate specification. Affects dihydroflavonol 4-reductase gene expression. It is thought that a ternary complex composed of TT2, TT8 and TTG1 is necessary for correct expression of BAN in seed endothelium. Based on clonal analysis and other methonds TTG1 has been shown to act non-cell autonomously and to move via plasmodesmata between cells.Localization and levels of TTG1 affect patterning of leaf trichomes. Auxin and ethylene responsiveness of TTG1 transcription is lost in myb12 mutants.
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Genomic context

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See TTG1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 4

Sequence:: Chromosome: 5; NC_003076.8 (8370317..8372847, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A pair of DUF538 domain-containing proteins modulates plant growth and trichome development through the transcriptional regulation of GLABRA1 in Arabidopsis thaliana.
Title: A pair of DUF538 domain-containing proteins modulates plant growth and trichome development through the transcriptional regulation of GLABRA1 in Arabidopsis thaliana.
MBW complex consisting of three kinds of regulatory proteins, MYB and basic helix-loop-helix (bHLH) transcription factors and a WD40 repeat protein, TRANSPARENT TESTA GLABRA1 (TTG1), acts in concert to promote trichome formation and flavonoid accumulation in Arabidopsis thaliana. TTG1 functions as an essential activator in these two biological processes.
Title: Genome-Wide Identification of Direct Targets of the TTG1-bHLH-MYB Complex in Regulating Trichome Formation and Flavonoid Accumulation in Arabidopsis Thaliana.
TTG1 interacts with bHLH proteins to regulate anthocyanin and proanthocyanidin biosynthesis
Title: A functional homologue of Arabidopsis TTG1 from Freesia interacts with bHLH proteins to regulate anthocyanin and proanthocyanidin biosynthesis in both Freesia hybrida and Arabidopsis thaliana.
insect community composition significantly varies among A. thaliana accessions across two distant field sites, with GLABRA1 playing a key role in altering the abundance of leaf-chewing herbivores.
Title: Plant trichomes and a single gene GLABRA1 contribute to insect community composition on field-grown Arabidopsis thaliana.
Site-specific phosphorylation of TTG1 by SK11/SK12 regulates carbon partitioning between zygotic and maternal sinks in seeds.
Title: Site-specific phosphorylation of TRANSPARENT TESTA GLABRA1 mediates carbon partitioning in Arabidopsis seeds.
TTG1 is a direct target of FUS3 in the framework of the regulatory hierarchy controlling seed filling.
Title: TRANSPARENT TESTA GLABRA1 Regulates the Accumulation of Seed Storage Reserves in Arabidopsis.
GL1 represses the activation of the TRY promoter by GL3 and TTG1, and TTG1 suppresses the activation of the CPC promoter by GL1 and GL3.
Title: TRANSPARENT TESTA GLABRA1 and GLABRA1 Compete for Binding to GLABRA3 in Arabidopsis.
Proteolytic degradation of the flavonoid regulators, TRANSPARENT TESTA8 and TRANSPARENT TESTA GLABRA1, in Arabidopsis is mediated by the ubiquitin/26Sproteasome system
Title: Proteolytic degradation of the flavonoid regulators, TRANSPARENT TESTA8 and TRANSPARENT TESTA GLABRA1, in Arabidopsis is mediated by the ubiquitin/26Sproteasome system.
Lateral root following abscisic acid treatment was reduced in ttg1 seedlings and increased in plants overexpressing TTG1.
Title: TTG1-mediated flavonols biosynthesis alleviates root growth inhibition in response to ABA.
TTG1 trapping by GL3 is based on direct interaction between both proteins and recruitment in the nucleus.
Title: Nuclear trapping by GL3 controls intercellular transport and redistribution of TTG1 protein in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001343878.1

Supported by ESTs:

NM_122360.2

Supported by ESTs:

NM_180738.3

Supported by ESTs:

NM_180739.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant epidermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to auxin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to ethylene	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within trichome differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Transducin/WD40 repeat-like superfamily protein

NP_001318637.1

TRANSPARENT TESTA GLABRA 1 (TTG1); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G12910.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NP_851069.1

TRANSPARENT TESTA GLABRA 1 (TTG1); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G12910.1); Has 6142 Blast hits to 5599 proteins in 374 species: Archae - 8; Bacteria - 429; Metazoa - 2235; Fungi - 1639; Plants - 1018; Viruses - 0; Other Eukaryotes - 813 (source: NCBI BLink).

NP_851070.1

TRANSPARENT TESTA GLABRA 1 (TTG1); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40 repeat, conserved site (InterPro:IPR019775), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat (InterPro:IPR001680), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT1G12910.1); Has 6142 Blast hits to 5599 proteins in 374 species: Archae - 8; Bacteria - 429; Metazoa - 2235; Fungi - 1639; Plants - 1018; Viruses - 0; Other Eukaryotes - 813 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

8370317..8372847 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_180738.3 → NP_851069.1 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_851069.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5PP66, Q9FT87, Q9XGN1

UniProtKB/TrEMBL

A0A178UQK6, A0A5S9Y6X7, Q5DWW6

Conserved Domains (2) summary

sd00039
Location:136 → 172

7WD40; WD40 repeat [structural motif]

cl29593
Location:82 → 293

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001343878.1 → NP_001318637.1 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5PP66, Q9FT87, Q9XGN1

UniProtKB/TrEMBL

A0A178UQK6, A0A5S9Y6X7, Q5DWW6

Conserved Domains (2) summary

sd00039
Location:136 → 172

7WD40; WD40 repeat [structural motif]

cl29593
Location:82 → 293

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_180739.2 → NP_851070.1 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_851070.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5PP66, Q9FT87, Q9XGN1

UniProtKB/TrEMBL

A0A178UQK6, A0A5S9Y6X7, Q5DWW6

Conserved Domains (2) summary

sd00039
Location:136 → 172

7WD40; WD40 repeat [structural motif]

cl29593
Location:82 → 293

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_122360.2 → NP_197840.1 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_197840.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q5PP66, Q9FT87, Q9XGN1

UniProtKB/TrEMBL

A0A178UQK6, A0A5S9Y6X7, Q5DWW6

Conserved Domains (2) summary

sd00039
Location:136 → 172

7WD40; WD40 repeat [structural motif]

cl29593
Location:82 → 293

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...