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    APG7 ThiF family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834630, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APG7
    Official Full Name
    ThiF family protein
    Primary source
    TAIR:AT5G45900
    Locus tag
    AT5G45900
    See related
    Araport:AT5G45900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATAPG7; ATATG7; ATG7; AUTOPHAGY 7; AUTOPHAGY-RELATED 7; K15I22.10; K15I22_10; PEROXISOME UNUSUAL POSITIONING 4; PEUP4
    Summary
    Component of autophagy conjugation pathway. Required for proper senescence. Contributes to plant basal immunity towards fungal infection.
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    Genomic context

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    See APG7 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    11
    Sequence:
    Chromosome: 5; NC_003076.8 (18615175..18618597)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pollen Ole e 1 allergen and extensin family protein Neighboring gene senescence-associated gene 12 Neighboring gene ncRNA Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The autophagy receptor NBR1 directs the clearance of photodamaged chloroplasts. Lee HN, et al. Elife, 2023 Apr 18. PMID 37070813, Free PMC Article
    2. Senescence-associated vacuoles with intense proteolytic activity develop in leaves of Arabidopsis and soybean. Otegui MS, et al. Plant J, 2005 Mar. PMID 15743448
    3. Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness. Minina EA, et al. J Exp Bot, 2018 Mar 14. PMID 29365132, Free PMC Article
    4. Noncanonical recognition and UBL loading of distinct E2s by autophagy-essential Atg7. Yamaguchi M, et al. Nat Struct Mol Biol, 2012 Dec. PMID 23142983
    5. The APG8/12-activating enzyme APG7 is required for proper nutrient recycling and senescence in Arabidopsis thaliana. Doelling JH, et al. J Biol Chem, 2002 Sep 6. PMID 12070171

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. After screening mutagenized lon2-2 seedlings for restored indole-3-butyric acid responsiveness, stabilization and processing of peroxisomal proteins, levels of several ATG proteins, and levels of the selective autophagy receptor NBR1/At4g24690, which accumulates when autophagy is impaired, were evaluated. The study recovered 21 alleles disrupting 6 ATG genes: ATG2, ATG3, ATG5, ATG7, ATG16, and ATG18a.
      Title: A facile forward-genetic screen for Arabidopsis autophagy mutants reveals twenty-one loss-of-function mutations disrupting six ATG genes.
    2. Overexpression of ATG5 or ATG7 stimulates Atg8 lipidation, autophagosome formation, and autophagic flux. It also induces transcriptional changes opposite to those observed in atg5 and atg7 mutants, favoring stress resistance and growth.
      Title: Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_123958.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables Atg8 activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein lipidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ThiF family protein
    NP_568652.1
    • AUTOPHAGY 7 (APG7); FUNCTIONS IN: APG8 activating enzyme activity; INVOLVED IN: autophagy, protein amino acid lipidation, leaf senescence, aging; LOCATED IN: cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: E1-like protein-activating enzyme Gsa7p/Apg7p (InterPro:IPR006285), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18615175..18618597
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_123958.3 → NP_568652.1  ThiF family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568652.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94CD5, Q9FJ46
      UniProtKB/TrEMBL
      A0A178UF73
      Conserved Domains (1) summary
      TIGR01381
      Location:13 → 681
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94CD5.1

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