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    MEF1 mitochondrial RNAediting factor 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835340, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MEF1
    Official Full Name
    mitochondrial RNAediting factor 1
    Primary source
    TAIR:AT5G52630
    Locus tag
    AT5G52630
    See related
    Araport:AT5G52630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F6N7.12; F6N7_12; mitochondrial RNA editing factor 1; mitochondrial RNAediting factor 1
    Summary
    Encodes a member of the DYW subfamily of pentatricopeptide repeat (PPR) proteins. Loss of MEF1 function affects RNA editing at specific sites in the mitochondrial genome but do not exhibit obvious phenotypes.
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    Genomic context

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    See MEF1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (21350375..21352333)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene F-box and associated interaction domains-containing protein Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene heat shock-like protein Neighboring gene RNA binding Plectin/S10 domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA editing competence of trans-factor MEF1 is modulated by ecotype-specific differences but requires the DYW domain. Zehrmann A, et al. FEBS Lett, 2010 Oct 8. PMID 20828567
    2. A DYW domain-containing pentatricopeptide repeat protein is required for RNA editing at multiple sites in mitochondria of Arabidopsis thaliana. Zehrmann A, et al. Plant Cell, 2009 Feb. PMID 19252080, Free PMC Article
    3. Multiple organellar RNA editing factor (MORF) family proteins are required for RNA editing in mitochondria and plastids of plants. Takenaka M, et al. Proc Natl Acad Sci U S A, 2012 Mar 27. PMID 22411807, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RNA editing trans-factor MEF1 was identified via ecotype-specific editing polymorphisms. Complementation assays reveal that none of the three amino acid changes between Columbia (Col) and C24 individually alters RNA editing.
      Title: RNA editing competence of trans-factor MEF1 is modulated by ecotype-specific differences but requires the DYW domain.
    2. MEF1 is involved in RNA editing of three specific sites in different mitochondrial mRNAs in Arabidopsis thaliana.
      Title: A DYW domain-containing pentatricopeptide repeat protein is required for RNA editing at multiple sites in mitochondria of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytidine to uridine editing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial RNAediting factor 1
    NP_200075.1
    • mitochondrial RNAediting factor 1 (MEF1); CONTAINS InterPro DOMAIN/s: Pentatricopeptide repeat (InterPro:IPR002885); BEST Arabidopsis thaliana protein match is: Pentatricopeptide repeat (PPR) superfamily protein (TAIR:AT5G04780.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21350375..21352333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124641.2 → NP_200075.1  mitochondrial RNAediting factor 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200075.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LTF4
      UniProtKB/TrEMBL
      A0A178UI41
      Conserved Domains (5) summary
      TIGR00756
      Location:285 → 317
      PPR; pentatricopeptide repeat domain (PPR motif)
      sd00004
      Location:285 → 312
      PPR; PPR repeat [structural motif]
      pfam01535
      Location:183 → 207
      PPR; PPR repeat
      pfam13041
      Location:181 → 229
      PPR_2; PPR repeat family
      pfam14432
      Location:455 → 578
      DYW_deaminase; DYW family of nucleic acid deaminases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LTF4.1

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