CNX5 co-factor for nitrate, reductase and xanthine dehydrogenase 5 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CNX5
Official Full Name: co-factor for nitrate, reductase and xanthine dehydrogenase 5
Primary source: TAIR:AT5G55130
Locus tag: AT5G55130
See related: Araport:AT5G55130
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ''co-factor for nitrate; co-factor for nitrate; MCO15.8; MCO15_8; reductase and xanthine dehydrogenase 5; reductase and xanthine dehydrogenase 5''; SIR1; SIRTINOL RESISTANT 1
Summary: putative molybdopterin synthase sulphurylase (cnx5)
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Genomic context

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See CNX5 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 11

Sequence:: Chromosome: 5; NC_003076.8 (22373168..22376138, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

URM11 and URM12, which both are active in the tRNA thiolation process and influence root development.
Title: Ubiquitin-related modifiers of Arabidopsis thaliana influence root development.
Arabidopsis molybdopterin biosynthesis protein Cnx5 collaborates with the ubiquitin-like protein Urm11 in the thio-modification of tRNA.
Title: Arabidopsis molybdopterin biosynthesis protein Cnx5 collaborates with the ubiquitin-like protein Urm11 in the thio-modification of tRNA.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_001036999.1

Supported by ESTs:

NM_001345117.1

Supported by ESTs:

NM_124895.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molybdenum cofactor sulfurtransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables molybdopterin-synthase adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables molybdopterin-synthase sulfurtransferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like modifier activating enzyme activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA wobble position uridine thiolation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: co-factor for nitrate, reductase and xanthine dehydrogenase 5

NP_001032076.1

''co-factor for nitrate, reductase and xanthine dehydrogenase 5'' (CNX5); FUNCTIONS IN: Mo-molybdopterin cofactor sulfurase activity; INVOLVED IN: metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Rhodanese-like (InterPro:IPR001763), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), NAD(P)-binding domain (InterPro:IPR016040), MoeZ/MoeB (InterPro:IPR007901); BEST Arabidopsis thaliana protein match is: SUMO-activating enzyme 2 (TAIR:AT2G21470.2); Has 14042 Blast hits to 14039 proteins in 2395 species: Archae - 240; Bacteria - 9204; Metazoa - 714; Fungi - 607; Plants - 341; Viruses - 0; Other Eukaryotes - 2936 (source: NCBI BLink).

NP_200324.1

''co-factor for nitrate, reductase and xanthine dehydrogenase 5'' (CNX5); FUNCTIONS IN: Mo-molybdopterin cofactor sulfurase activity; INVOLVED IN: metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Rhodanese-like (InterPro:IPR001763), Molybdenum cofactor biosynthesis, MoeB (InterPro:IPR009036), UBA/THIF-type NAD/FAD binding fold (InterPro:IPR000594), NAD(P)-binding domain (InterPro:IPR016040), MoeZ/MoeB (InterPro:IPR007901); BEST Arabidopsis thaliana protein match is: SUMO-activating enzyme 2 (TAIR:AT2G21470.2); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

22373168..22376138 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001036999.1 → NP_001032076.1 co-factor for nitrate, reductase and xanthine dehydrogenase 5 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001032076.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A654GB18

Conserved Domains (3) summary

PRK07411
Location:64 → 437

PRK07411; hypothetical protein; Validated

cd00757
Location:71 → 272

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...

cd01526
Location:311 → 437

RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...
NM_001345117.1 → NP_001330104.1 co-factor for nitrate, reductase and xanthine dehydrogenase 5 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B9T0
NM_124895.3 → NP_200324.1 co-factor for nitrate, reductase and xanthine dehydrogenase 5 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_200324.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DGV4, Q058R2, Q9ZNW0

UniProtKB/TrEMBL

A0A5S9YE65, A0A654GB18

Conserved Domains (2) summary

cd00757
Location:71 → 299

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...

cd01526
Location:338 → 464

RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...