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    KCO1 Outward rectifying potassium channel protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835657, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KCO1
    Official Full Name
    Outward rectifying potassium channel protein
    Primary source
    TAIR:AT5G55630
    Locus tag
    AT5G55630
    See related
    Araport:AT5G55630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATKCO1; ATTPK1; CA2+ ACTIVATED OUTWARD RECTIFYING K+ CHANNEL 1; MDF20.7; MDF20_7; TANDEM PORE K+ CHANNEL 1; TPK1; TWO PORE K CHANNEL; TWO PORE K CHANNEL 1
    Summary
    Encodes AtTPK1 (KCO1), a member of the Arabidopsis thaliana K+ channel family of AtTPK/KCO proteins. AtTPK1 is targeted to the vacuolar membrane. Forms homomeric ion channels in vivo. Voltage-independent and Ca2+-activated K+ channel. Activated by 14-3-3 proteins.
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    Genomic context

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    See KCO1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (22531358..22533122)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene Na-translocating NADH-quinone reductase subunit A Neighboring gene uncharacterized protein Neighboring gene DEK domain-containing chromatin associated protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assembly and sorting of the tonoplast potassium channel AtTPK1 and its turnover by internalization into the vacuole. Maîtrejean M, et al. Plant Physiol, 2011 Aug. PMID 21697507, Free PMC Article
    2. Targeting of vacuolar membrane localized members of the TPK channel family. Dunkel M, et al. Mol Plant, 2008 Nov. PMID 19825594
    3. The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis. Gobert A, et al. Proc Natl Acad Sci U S A, 2007 Jun 19. PMID 17563365, Free PMC Article
    4. TPK1 is a vacuolar ion channel different from the slow-vacuolar cation channel. Bihler H, et al. Plant Physiol, 2005 Sep. PMID 16113216, Free PMC Article
    5. Vacuolar membrane localization of the Arabidopsis 'two-pore' K+ channel KCO1. Czempinski K, et al. Plant J, 2002 Mar. PMID 12148538

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ATKCO1 can form functional potassium transport systems in E. coli
      Title: Arabidopsis thaliana vacuolar TPK channels form functional K⁺ uptake pathways in Escherichia coli.
    2. an essential role of the vacuolar potassium channel TPK1 in salt-stress adaptation
      Title: Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium-dependent protein kinases (CDPKs).
    3. TPK1 must assemble correctly to pass endoplasmic reticulum quality control.
      Title: Assembly and sorting of the tonoplast potassium channel AtTPK1 and its turnover by internalization into the vacuole.
    4. findings show that AtTPK1 (KCO1), interacts with 14-3-3 proteins (general regulating factors, GRFs; TPK1 seems to provide for a Ca(2+)- and 14-3-3-sensitive mechanism capable of controlling cytoplasmic potassium homeostasis in plants
      Title: TPK1, a Ca(2+)-regulated Arabidopsis vacuole two-pore K(+) channel is activated by 14-3-3 proteins.
    5. data clearly demonstrate that TPK1 (KCO1) is a voltage-independent, Ca(2+)-activated, K(+)-selective ion channel in the vacuolar membrane that does not mediate SV-type ionic currents [TPK1]
      Title: TPK1 is a vacuolar ion channel different from the slow-vacuolar cation channel.
    6. The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis.
      Title: The two-pore channel TPK1 gene encodes the vacuolar K+ conductance and plays a role in K+ homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_124945.4
    NM_180865.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables outward rectifier potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables outward rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to electrical stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular potassium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion export across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of seed germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    colocalizes_with vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Outward rectifying potassium channel protein
    NP_200374.1
    • TWO PORE K CHANNEL (KCO1); CONTAINS InterPro DOMAIN/s: Potassium channel, two pore-domain (InterPro:IPR003280), EF-Hand 1, calcium-binding site (InterPro:IPR018247), Ion transport 2 (InterPro:IPR013099); BEST Arabidopsis thaliana protein match is: Ca2+ activated outward rectifying K+ channel 5 (TAIR:AT4G01840.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_851196.1
    • ATKCO1; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), Potassium channel, two pore-domain (InterPro:IPR003280), Ion transport 2 (InterPro:IPR013099); BEST Arabidopsis thaliana protein match is: Ca2+ activated outward rectifying K+ channel 5 (TAIR:AT4G01840.1); Has 4513 Blast hits to 4370 proteins in 1126 species: Archae - 145; Bacteria - 2057; Metazoa - 1231; Fungi - 181; Plants - 220; Viruses - 0; Other Eukaryotes - 679 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22531358..22533122
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124945.4 → NP_200374.1  Outward rectifying potassium channel protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200374.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04718, Q0WNY4, Q8LBL1, Q9FM75
      UniProtKB/TrEMBL
      A0A178URA8, A0A5S9YEU9
      Conserved Domains (2) summary
      COG5126
      Location:235 → 353
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam07885
      Location:202 → 277
      Ion_trans_2; Ion channel

    2. NM_180865.1 → NP_851196.1  Outward rectifying potassium channel protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851196.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04718, Q0WNY4, Q8LBL1, Q9FM75
      UniProtKB/TrEMBL
      A0A178URA8, A0A5S9YEU9
      Conserved Domains (2) summary
      COG5126
      Location:235 → 353
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
      pfam07885
      Location:202 → 277
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LBL1.2

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