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    ACX2 acyl-CoA oxidase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836635, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACX2
    Official Full Name
    acyl-CoA oxidase 2
    Primary source
    TAIR:AT5G65110
    Locus tag
    AT5G65110
    See related
    Araport:AT5G65110
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acyl-CoA oxidase 2; ACYL-COA OXIDASE 2; ATACX2; MQN23.4; MQN23_4
    Summary
    Encodes an acyl-CoA oxidase presumably involved in long chain fatty acid biosynthesis.
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    Genomic context

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    See ACX2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (26009521..26012684, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene K-box region/MADS-box transcription factor family protein Neighboring gene DNAse I-like superfamily protein Neighboring gene Ethylene insensitive 3 family protein Neighboring gene DNA-directed RNA polymerase subunit beta Neighboring gene Integrase-type DNA-binding superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Long-chain acyl-CoA oxidases of Arabidopsis. Hooks MA, et al. Plant J, 1999 Oct. PMID 10571860
    2. CATALASE2 functions for seedling postgerminative growth by scavenging H(2) O(2) and stimulating ACX2/3 activity in Arabidopsis. Liu WC, et al. Plant Cell Environ, 2017 Nov. PMID 28722222
    3. Peroxisomal Acyl-CoA oxidase 4 activity differs between Arabidopsis accessions. Khan BR, et al. Plant Mol Biol, 2012 Jan. PMID 22048901
    4. ABI4 activates DGAT1 expression in Arabidopsis seedlings during nitrogen deficiency. Yang Y, et al. Plant Physiol, 2011 Jun. PMID 21515696, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CAT2 functions in early seedling growth by scavenging hydrogen peroxide and stimulating ACX2/3 activity.
      Title: CATALASE2 functions for seedling postgerminative growth by scavenging H(2) O(2) and stimulating ACX2/3 activity in Arabidopsis.
    2. Data show that ACX5 levels were similar in the triple mutant and wild type, but ACX2 levels were increased in acx1acx3acx4 Columbia (Col) compared to wild-type.
      Title: Peroxisomal Acyl-CoA oxidase 4 activity differs between Arabidopsis accessions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001037068.1
    NM_125910.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyl-CoA oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid beta-oxidation using acyl-CoA oxidase IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acyl-CoA oxidase 2
    NP_001032145.1
    • acyl-CoA oxidase 2 (ACX2); CONTAINS InterPro DOMAIN/s: Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal (InterPro:IPR013764), Acyl-CoA oxidase/dehydrogenase, type 1 (InterPro:IPR006090), Acyl-CoA dehydrogenase/oxidase (InterPro:IPR009100), Acyl-CoA oxidase (InterPro:IPR012258), Acyl-CoA oxidase/dehydrogenase, central domain (InterPro:IPR006091), Acyl-CoA oxidase, C-terminal (InterPro:IPR002655), Acyl-CoA dehydrogenase/oxidase C-terminal (InterPro:IPR009075); BEST Arabidopsis thaliana protein match is: acyl-CoA oxidase 3 (TAIR:AT1G06290.1); Has 15850 Blast hits to 15835 proteins in 1495 species: Archae - 314; Bacteria - 10867; Metazoa - 1644; Fungi - 650; Plants - 316; Viruses - 0; Other Eukaryotes - 2059 (source: NCBI BLink).
    NP_201316.1
    • acyl-CoA oxidase 2 (ACX2); CONTAINS InterPro DOMAIN/s: Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal (InterPro:IPR013764), Acyl-CoA oxidase/dehydrogenase, type 1 (InterPro:IPR006090), Acyl-CoA dehydrogenase/oxidase (InterPro:IPR009100), Acyl-CoA oxidase (InterPro:IPR012258), Acyl-CoA oxidase/dehydrogenase, central domain (InterPro:IPR006091), Acyl-CoA oxidase, C-terminal (InterPro:IPR002655), Acyl-CoA dehydrogenase/oxidase C-terminal (InterPro:IPR009075); BEST Arabidopsis thaliana protein match is: acyl-CoA oxidase 3 (TAIR:AT1G06290.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26009521..26012684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125910.6 → NP_201316.1  acyl-CoA oxidase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201316.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65201, Q9FJQ4
      UniProtKB/TrEMBL
      A0A178UA38, A0A5S9YIB8, B9DG77
      Conserved Domains (1) summary
      PLN02636
      Location:4 → 692
      PLN02636; acyl-coenzyme A oxidase

    2. NM_001037068.1 → NP_001032145.1  acyl-CoA oxidase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032145.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9DG77, F4KGI8
      Conserved Domains (2) summary
      cd01150
      Location:42 → 642
      AXO; Peroxisomal acyl-CoA oxidase
      PLN02636
      Location:4 → 641
      PLN02636; acyl-coenzyme A oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65201.2

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