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    P5CR pyrroline-5- carboxylate (P5C) reductase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831332, updated on 18-Sep-2024

    Summary

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    Official Symbol
    P5CR
    Official Full Name
    pyrroline-5- carboxylate (P5C) reductase
    Primary source
    TAIR:AT5G14800
    Locus tag
    AT5G14800
    See related
    Araport:AT5G14800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AT-P5C1; AT-P5R; EMB2772; EMBRYO DEFECTIVE 2772; pyrroline-5- carboxylate (P5C) reductase; PYRROLINE-5- CARBOXYLATE (P5C) REDUCTASE; T9L3.100; T9L3_100
    Summary
    Delta 1-pyrroline-5-carboxylate reductase, catalyzes the final step in proline biosynthesis from glutamate and ornithine.In situ hybridization indicated that under normal growth conditions, the highest concentration of P5CR transcripts occurs in the cortical parenchyma, phloem, vascular cambium and pith parenchyma in the vicinity of the protoxylem. Single gene in Arabidopsis.
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    Genomic context

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    See P5CR in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    7
    Sequence:
    Chromosome: 5; NC_003076.8 (4785960..4787996, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene formate dehydrogenase Neighboring gene ARM repeat superfamily protein Neighboring gene pseudo Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Δ1-Pyrroline-5-carboxylate reductase from Arabidopsis thaliana: stimulation or inhibition by chloride ions and feedback regulation by proline depend on whether NADPH or NADH acts as co-substrate. Giberti S, et al. New Phytol, 2014 May. PMID 24467670
    2. Requirement of proline synthesis during Arabidopsis reproductive development. Funck D, et al. BMC Plant Biol, 2012 Oct 13. PMID 23062072, Free PMC Article
    3. Photosynthetic response of transgenic soybean plants, containing an Arabidopsis P5CR gene, during heat and drought stress. De Ronde JA, et al. J Plant Physiol, 2004 Nov. PMID 15602813
    4. The 5' untranslated region of the At-P5R gene is involved in both transcriptional and post-transcriptional regulation. Hua XJ, et al. Plant J, 2001 Apr. PMID 11389757
    5. Osmoregulation of a pyrroline-5-carboxylate reductase gene in Arabidopsis thaliana. Verbruggen N, et al. Plant Physiol, 1993 Nov. PMID 8022935, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The biochemical properties of A. thaliana P5CR suggest a complex regulation of enzyme activity by the redox status of the pyridine nucleotide pools, and the concentrations of proline and chloride in the cytosol.
      Title: Δ1-Pyrroline-5-carboxylate reductase from Arabidopsis thaliana: stimulation or inhibition by chloride ions and feedback regulation by proline depend on whether NADPH or NADH acts as co-substrate.
    2. Expression of P5C reductase (P5CR) is indispensable for embryo development but not needed for pollen or egg cell fertility.
      Title: Requirement of proline synthesis during Arabidopsis reproductive development.
    3. NADP levels in transgenic plants in response to heat and drought stress as compared to wild-type plants.
      Title: Photosynthetic response of transgenic soybean plants, containing an Arabidopsis P5CR gene, during heat and drought stress.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001085115.1
    NM_121484.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables pyrroline-5-carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables pyrroline-5-carboxylate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proline biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plant-type cell wall HDA PubMed 

    General protein information

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    Preferred Names
    pyrroline-5- carboxylate (P5C) reductase
    NP_001078584.1
    • pyrroline-5- carboxylate (P5C) reductase (P5CR); CONTAINS InterPro DOMAIN/s: NADP oxidoreductase, coenzyme F420-dependent (InterPro:IPR004455), NAD(P)-binding domain (InterPro:IPR016040), Delta 1-pyrroline-5-carboxylate reductase (InterPro:IPR000304); Has 7429 Blast hits to 7426 proteins in 2378 species: Archae - 102; Bacteria - 5104; Metazoa - 368; Fungi - 229; Plants - 70; Viruses - 0; Other Eukaryotes - 1556 (source: NCBI BLink).
    NP_196984.1
    • pyrroline-5- carboxylate (P5C) reductase (P5CR); FUNCTIONS IN: pyrroline-5-carboxylate reductase activity; INVOLVED IN: response to salt stress, response to heat, proline biosynthetic process; LOCATED IN: cell wall, cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NADP oxidoreductase, coenzyme F420-dependent (InterPro:IPR004455), NAD(P)-binding domain (InterPro:IPR016040), Delta 1-pyrroline-5-carboxylate reductase (InterPro:IPR000304); Has 7885 Blast hits to 7882 proteins in 2434 species: Archae - 115; Bacteria - 5234; Metazoa - 373; Fungi - 241; Plants - 70; Viruses - 0; Other Eukaryotes - 1852 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4785960..4787996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121484.5 → NP_196984.1  pyrroline-5- carboxylate (P5C) reductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196984.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P54904
      UniProtKB/TrEMBL
      A0A178UNE0, A0A5S9Y6F0, A0A654G132
      Conserved Domains (1) summary
      PLN02688
      Location:11 → 276
      PLN02688; pyrroline-5-carboxylate reductase

    2. NM_001085115.1 → NP_001078584.1  pyrroline-5- carboxylate (P5C) reductase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078584.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4K884
      Conserved Domains (3) summary
      PLN02688
      Location:11 → 215
      PLN02688; pyrroline-5-carboxylate reductase
      pfam03807
      Location:14 → 107
      F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
      pfam14748
      Location:168 → 215
      P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54904.1

    Gene LinkOut

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