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    SMG7 Telomerase activating protein Est1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832060, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SMG7
    Official Full Name
    Telomerase activating protein Est1
    Primary source
    TAIR:AT5G19400
    Locus tag
    AT5G19400
    See related
    Araport:AT5G19400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F7K24.150; F7K24_150
    Summary
    Encodes SMG7, a protein that possesses an evolutionarily conserved EST1 domain and exhibits strong homology to human SMG6 (EST1A) and SMG7 (EST1C) proteins. SMG7 plays an evolutionarily conserved role in nonsense-mediated RNA decay (NMD). Required for exit from meiosis. Hypomorphic smg7 alleles render mutant plants sterile by causing an unusual cell-cycle arrest in anaphase II that is characterized by delayed chromosome decondensation and aberrant rearrangement of the meiotic spindle. Disruption of SMG7 causes embryonic lethality.
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    Genomic context

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    See SMG7 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (6539926..6545081)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene CRT (chloroquine-resistance transporter)-like transporter 1 Neighboring gene Rho GTPase activation protein (RhoGAP) with PH domain-containing protein Neighboring gene ABC-2 type transporter family protein Neighboring gene Regulator of chromosome condensation (RCC1) family with FYVE zinc finger domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis. Capitao C, et al. PLoS Genet, 2021 Sep. PMID 34591845, Free PMC Article
    2. Arabidopsis SMG7 protein is required for exit from meiosis. Riehs N, et al. J Cell Sci, 2008 Jul 1. PMID 18544632
    3. The GYF domain protein PSIG1 dampens the induction of cell death during plant-pathogen interactions. Matsui H, et al. PLoS Genet, 2017 Oct. PMID 29073135, Free PMC Article
    4. Phosphorylation of the N- and C-terminal UPF1 domains plays a critical role in plant nonsense-mediated mRNA decay. Kerényi F, et al. Plant J, 2013 Dec. PMID 24118551
    5. The late steps of plant nonsense-mediated mRNA decay. Mérai Z, et al. Plant J, 2013 Jan. PMID 22974464

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis.
      Title: A CENH3 mutation promotes meiotic exit and restores fertility in SMG7-deficient Arabidopsis.
    2. PSIG1 interacts with SMG7, which plays a role in nonsense-mediated RNA decay (NMD), and the smg7-4 mutant allele mimics the cell death phenotype of the psig1 mutants.
      Title: The GYF domain protein PSIG1 dampens the induction of cell death during plant-pathogen interactions.
    3. Results propose a model that meiotic progression in Arabidopsis pollen mother cells is driven by a yet to be identified cyclin-CDK activity that is modulated by regulatory interactions between TDM1, SMG7, and TAM (CYCA1;2)
      Title: Meiotic progression in Arabidopsis is governed by complex regulatory interactions between SMG7, TDM1, and the meiosis I-specific cyclin TAM.
    4. Data indicates that SMG7 counteracts cyclin-dependent kinase (CDK) activity at the end of meiosis, and reveals a novel link between SMG7 and regulation of the meiotic cell cycle. [SMG7]
      Title: Arabidopsis SMG7 protein is required for exit from meiosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203408.1
    NM_121945.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meiotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Telomerase activating protein Est1
    NP_001190336.1
    • SMG7; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: meiosis, spindle assembly involved in meiosis, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Telomerase activating protein Est1 (InterPro:IPR019458); BEST Arabidopsis thaliana protein match is: Telomerase activating protein Est1 (TAIR:AT1G28260.2).
    NP_001190337.1
    • SMG7; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: meiosis, spindle assembly involved in meiosis, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Telomerase activating protein Est1 (InterPro:IPR019458); BEST Arabidopsis thaliana protein match is: Telomerase activating protein Est1 (TAIR:AT1G28260.2).
    NP_197441.3
    • SMG7; CONTAINS InterPro DOMAIN/s: Telomerase activating protein Est1 (InterPro:IPR019458); BEST Arabidopsis thaliana protein match is: Telomerase activating protein Est1 (TAIR:AT1G28260.2); Has 648 Blast hits to 623 proteins in 143 species: Archae - 0; Bacteria - 0; Metazoa - 367; Fungi - 169; Plants - 90; Viruses - 0; Other Eukaryotes - 22 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      6539926..6545081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001343597.1 → NP_001330788.1  Telomerase activating protein Est1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBV1, A0A654G344

    2. NM_001343598.1 → NP_001330789.1  Telomerase activating protein Est1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBV1, A0A654G344

    3. NM_001203407.2 → NP_001190336.1  Telomerase activating protein Est1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190336.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9QM73
      UniProtKB/TrEMBL
      A0A654G344
      Conserved Domains (2) summary
      pfam10373
      Location:203 → 533
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:66 → 189
      EST1; Telomerase activating protein Est1

    4. NM_121945.3 → NP_197441.3  Telomerase activating protein Est1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197441.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9QM73
      UniProtKB/TrEMBL
      A0A654G344
      Conserved Domains (2) summary
      pfam10373
      Location:203 → 533
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:66 → 189
      EST1; Telomerase activating protein Est1

    5. NM_001203408.1 → NP_001190337.1  Telomerase activating protein Est1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190337.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9QM73
      UniProtKB/TrEMBL
      A0A654G344
      Conserved Domains (2) summary
      pfam10373
      Location:203 → 533
      EST1_DNA_bind; Est1 DNA/RNA binding domain
      pfam10374
      Location:66 → 189
      EST1; Telomerase activating protein Est1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A9QM73.1

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