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    RPP4 Disease resistance protein (TIR-NBS-LRR class) family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827395, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RPP4
    Official Full Name
    Disease resistance protein (TIR-NBS-LRR class) family
    Primary source
    TAIR:AT4G16860
    Locus tag
    AT4G16860
    See related
    Araport:AT4G16860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DL4460C; FCAALL.47; recognition of peronospora parasitica 4
    Summary
    Confers resistance to Peronospora parasitica. RPP4 is coordinately regulated by transcriptional activation and RNA silencing.
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    Genomic context

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    See RPP4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    6
    Sequence:
    Chromosome: 4; NC_003075.7 (9488466..9495837, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene disease resistance protein (TIR-NBS-LRR class) family protein Neighboring gene pseudo Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A gain-of-function mutation in the Arabidopsis disease resistance gene RPP4 confers sensitivity to low temperature. Huang X, et al. Plant Physiol, 2010 Oct. PMID 20699401, Free PMC Article
    2. Arabidopsis HSP90 protein modulates RPP4-mediated temperature-dependent cell death and defense responses. Bao F, et al. New Phytol, 2014 Jun. PMID 24611624
    3. Arabidopsis RPP4 is a member of the RPP5 multigene family of TIR-NB-LRR genes and confers downy mildew resistance through multiple signalling components. van der Biezen EA, et al. Plant J, 2002 Feb. PMID 11846877
    4. Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation. Xia S, et al. Plant Physiol, 2013 Jul. PMID 23690534, Free PMC Article
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via histone H3 lysine trimethylation.
      Title: Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation.
    2. An amino acid substitution in RPP4 leads to a cold temperature-dependent gain-of-function phenotype.
      Title: A gain-of-function mutation in the Arabidopsis disease resistance gene RPP4 confers sensitivity to low temperature.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001341144.1
    NM_117790.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables LRR domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in defense response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Disease resistance protein (TIR-NBS-LRR class) family
    NP_193420.2
    • recognition of peronospora parasitica 4 (RPP4); FUNCTIONS IN: LRR domain binding; INVOLVED IN: defense response to fungus, incompatible interaction, defense response; LOCATED IN: intrinsic to membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NB-ARC (InterPro:IPR002182), Leucine-rich repeat (InterPro:IPR001611), Disease resistance protein (InterPro:IPR000767), Toll-Interleukin receptor (InterPro:IPR000157); BEST Arabidopsis thaliana protein match is: Disease resistance protein (TIR-NBS-LRR class) family (TAIR:AT4G16920.1); Has 24682 Blast hits to 14766 proteins in 601 species: Archae - 8; Bacteria - 1131; Metazoa - 1818; Fungi - 127; Plants - 20736; Viruses - 36; Other Eukaryotes - 826 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9488466..9495837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117790.4 → NP_193420.2  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193420.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JNA9, O23527, O23528, Q8GW40, Q8L843, Q8S4Q0
      UniProtKB/TrEMBL
      A0A346XQJ3
      Conserved Domains (5) summary
      PLN03210
      Location:13 → 1081
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:609 → 631
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:13 → 175
      TIR; TIR domain
      pfam07725
      Location:608 → 626
      LRR_3; Leucine Rich Repeat
      pfam13401
      Location:206 → 306
      AAA_22; AAA domain

    2. NM_001341144.1 → NP_001328661.1  Disease resistance protein (TIR-NBS-LRR class) family [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B5C3, A0A346XQK7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JNA9.1

    Gene LinkOut

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