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    ACX1 acyl-CoA oxidase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827381, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ACX1
    Official Full Name
    acyl-CoA oxidase 1
    Primary source
    TAIR:AT4G16760
    Locus tag
    AT4G16760
    See related
    Araport:AT4G16760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    acyl-CoA oxidase 1; ATACX1; DL4405C; FCAALL.119
    Summary
    Encodes a medium to long-chain acyl-CoA oxidase. Catalyzes the first step of fatty acid beta-oxidation. Involved in jasmonate biosynthesis. Gene expression is induced by wounding, drought stress, abscisic acid, and jasmonate.
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    Genomic context

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    See ACX1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    14
    Sequence:
    Chromosome: 4; NC_003075.7 (9424534..9428895, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, purification and crystallization of two peroxisomal acyl-CoA oxidases from Arabidopsis thaliana. Pedersen L, et al. Acta Crystallogr D Biol Crystallogr, 2004 Jun. PMID 15159576
    2. Sucrose rescues seedling establishment but not germination of Arabidopsis mutants disrupted in peroxisomal fatty acid catabolism. Pinfield-Wells H, et al. Plant J, 2005 Sep. PMID 16146525
    3. Long-chain acyl-CoA oxidases of Arabidopsis. Hooks MA, et al. Plant J, 1999 Oct. PMID 10571860
    4. Acyl-CoA oxidase 1 from Arabidopsis thaliana. Structure of a key enzyme in plant lipid metabolism. Pedersen L, et al. J Mol Biol, 2005 Jan 21. PMID 15581893
    5. Functional diversification of acyl-coenzyme A oxidases in jasmonic acid biosynthesis and action. Schilmiller AL, et al. Plant Physiol, 2007 Feb. PMID 17172287, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that acx3acx4 Columbia (Col) and acx1acx3acx4(Col) mutants are viable and that enzyme activity in these mutants is significantly reduced on a range of substrates compared to wild type.
      Title: Peroxisomal Acyl-CoA oxidase 4 activity differs between Arabidopsis accessions.
    2. The effects of mutations in ACX1 and ACX5 in A. thaliana on jasmonic acid synthesis are reported.
      Title: Functional diversification of acyl-coenzyme A oxidases in jasmonic acid biosynthesis and action.
    3. x-ray crystallography of two peroxisomal acyl-CoA oxidases, ACX1 and ACX4, from Arabidopsis thaliana
      Title: Expression, purification and crystallization of two peroxisomal acyl-CoA oxidases from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203815.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acyl-CoA oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acyl-CoA oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables acyl-CoA oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to insect IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid beta-oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid beta-oxidation NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within jasmonic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    acyl-CoA oxidase 1
    NP_001190744.1
    • acyl-CoA oxidase 1 (ACX1); CONTAINS InterPro DOMAIN/s: Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal (InterPro:IPR013764), Acyl-CoA dehydrogenase/oxidase (InterPro:IPR009100), Acyl-CoA dehydrogenase/oxidase, N-terminal (InterPro:IPR013786), Acyl-CoA oxidase (InterPro:IPR012258), Acyl-CoA oxidase/dehydrogenase, central domain (InterPro:IPR006091), Acyl-CoA oxidase, C-terminal (InterPro:IPR002655), Acyl-CoA dehydrogenase/oxidase C-terminal (InterPro:IPR009075); BEST Arabidopsis thaliana protein match is: acyl-CoA oxidase 5 (TAIR:AT2G35690.1).
    NP_567513.4
    • acyl-CoA oxidase 1 (ACX1); FUNCTIONS IN: acyl-CoA oxidase activity; INVOLVED IN: in 8 processes; LOCATED IN: peroxisome; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Acyl-CoA oxidase/dehydrogenase, type1/2, C-terminal (InterPro:IPR013764), Acyl-CoA dehydrogenase/oxidase (InterPro:IPR009100), Acyl-CoA oxidase (InterPro:IPR012258), Acyl-CoA dehydrogenase/oxidase, N-terminal (InterPro:IPR013786), Acyl-CoA oxidase/dehydrogenase, central domain (InterPro:IPR006091), Acyl-CoA oxidase, C-terminal (InterPro:IPR002655), Acyl-CoA dehydrogenase/oxidase C-terminal (InterPro:IPR009075); BEST Arabidopsis thaliana protein match is: acyl-CoA oxidase 5 (TAIR:AT2G35690.1); Has 9148 Blast hits to 9129 proteins in 1186 species: Archae - 124; Bacteria - 6076; Metazoa - 1261; Fungi - 445; Plants - 255; Viruses - 0; Other Eukaryotes - 987 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9424534..9428895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117778.8 → NP_567513.4  acyl-CoA oxidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567513.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23518, O65202
      UniProtKB/TrEMBL
      A0A654FQF7
      Conserved Domains (2) summary
      PLN02443
      Location:1 → 664
      PLN02443; acyl-coenzyme A oxidase
      cl09933
      Location:6 → 635
      ACAD; Acyl-CoA dehydrogenase

    2. NM_001203815.1 → NP_001190744.1  acyl-CoA oxidase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190744.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FQF7, F4JMK8
      Conserved Domains (2) summary
      PLN02443
      Location:1 → 651
      PLN02443; acyl-coenzyme A oxidase
      cl09933
      Location:6 → 622
      ACAD; Acyl-CoA dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65202.1

    Gene LinkOut

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