PAF1 proteasome alpha subunit F1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PAF1
Official Full Name: proteasome alpha subunit F1
Primary source: TAIR:AT5G42790
Locus tag: AT5G42790
See related: Araport:AT5G42790
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 20S PROTEASOME SUBUNIT PAF1; ARS5; ARSENIC TOLERANCE 5; ATPSM30; MJB21.17; MJB21_17; proteasome alpha subunit F1
Summary: encodes a protein with extensive homology to the largest subunit of the multicatalytic proteinase complex (proteasome). Negatively regulates thiol biosynthesis and arsenic tolerance.
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Genomic context

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See PAF1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 2

Sequence:: Chromosome: 5; NC_003076.8 (17159044..17161156, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The SNW Domain of SKIP Is Required for Its Integration into the Spliceosome and Its Interaction with the Paf1 Complex in Arabidopsis
Title: The SNW Domain of SKIP Is Required for Its Integration into the Spliceosome and Its Interaction with the Paf1 Complex in Arabidopsis.
SKIP interacted with the Paf1c to modulate the expression of FLC clade genes at the transcriptional level.
Title: SKIP Interacts with the Paf1 Complex to Regulate Flowering via the Activation of FLC Transcription in Arabidopsis.
ARS5 encodes the proteasome alpha subunit F1 protein (PAF1) of the 26S proteasome complex, and is also a negative regulator of thiol-mediated arsenic tolerance.
Title: ARS5 is a component of the 26S proteasome complex, and negatively regulates thiol biosynthesis and arsenic tolerance in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_123644.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within response to arsenic-containing substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in plastid	HDA more info	PubMed
part_of proteasome complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of proteasome core complex	TAS Traceable Author Statement more info	PubMed
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteasome alpha subunit F1

NP_199093.1

proteasome alpha subunit F1 (PAF1); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: response to arsenic, protein catabolic process, ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: 20S proteasome alpha subunit F2 (TAIR:AT1G47250.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

17159044..17161156 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_123644.5 → NP_199093.1 proteasome alpha subunit F1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_199093.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O81150, P34066, Q8LF69

UniProtKB/TrEMBL

A0A178UFX8, A0A5S9YAB2, A0A654G7B2

Conserved Domains (1) summary

cd03749
Location:6 → 215

proteasome_alpha_type_1; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...