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    ALA2 aminophospholipid ATPase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834447, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALA2
    Official Full Name
    aminophospholipid ATPase 2
    Primary source
    TAIR:AT5G44240
    Locus tag
    AT5G44240
    See related
    Araport:AT5G44240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    aminophospholipid ATPase 2; MLN1.17; MLN1_17
    Summary
    Expression is upregulated in the shoot of cax1/cax3 mutant.
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    Genomic context

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    See ALA2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    25
    Sequence:
    Chromosome: 5; NC_003076.8 (17816904..17823708)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene F-box family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene peptidase, S9A/B/C family, catalytic domain protein (Protein of unknown function DUF829, transmembrane 53) Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The lipid head group is the key element for substrate recognition by the P4 ATPase ALA2: a phosphatidylserine flippase. Theorin L, et al. Biochem J, 2019 Mar 6. PMID 30755463, Free PMC Article
    2. Lipid flippases promote antiviral silencing and the biogenesis of viral and host siRNAs in Arabidopsis. Guo Z, et al. Proc Natl Acad Sci U S A, 2017 Feb 7. PMID 28123063, Free PMC Article
    3. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787
    4. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article
    5. Arabidopsis plasmodesmal proteome. Fernandez-Calvino L, et al. PLoS One, 2011 Apr 20. PMID 21533090, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_123791.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in endosome HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 
    located_in trans-Golgi network HDA PubMed 

    General protein information

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    Preferred Names
    aminophospholipid ATPase 2
    NP_001190471.1
    • aminophospholipid ATPase 2 (ALA2); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; INVOLVED IN: metabolic process, phospholipid transport, ATP biosynthetic process; LOCATED IN: integral to membrane, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, phospholipid-translocating, flippase (InterPro:IPR006539), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: aminophospholipid ATPase 1 (TAIR:AT5G04930.1).
    NP_568633.2
    • aminophospholipid ATPase 2 (ALA2); FUNCTIONS IN: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism; INVOLVED IN: metabolic process, phospholipid transport, ATP biosynthetic process; LOCATED IN: integral to membrane, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Haloacid dehalogenase-like hydrolase (InterPro:IPR005834), ATPase, P-type, phospholipid-translocating, flippase (InterPro:IPR006539), ATPase, P-type, ATPase-associated domain (InterPro:IPR008250), ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter (InterPro:IPR001757), ATPase, P-type phosphorylation site (InterPro:IPR018303); BEST Arabidopsis thaliana protein match is: aminophospholipid ATPase 1 (TAIR:AT5G04930.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      17816904..17823708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203542.2 → NP_001190471.1  aminophospholipid ATPase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190471.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P98205, Q84ME2, Q8W567
      UniProtKB/TrEMBL
      A0A178URB2, A0A5S9YB18, A0A654G7R8
      Conserved Domains (2) summary
      cd07536
      Location:19 → 907
      P-type_ATPase_APLT; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C
      pfam13246
      Location:437 → 533
      Cation_ATPase; Cation transport ATPase (P-type)

    2. NM_123791.3 → NP_568633.2  aminophospholipid ATPase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568633.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178URB2, A0A5S9YB18, F4K8T6
      Conserved Domains (6) summary
      TIGR01652
      Location:50 → 1056
      ATPase-Plipid; phospholipid-translocating P-type ATPase, flippase
      pfam00122
      Location:105 → 193
      E1-E2_ATPase; E1-E2 ATPase
      pfam13246
      Location:469 → 565
      Cation_ATPase; Cation transport ATPase (P-type)
      pfam16209
      Location:37 → 100
      PhoLip_ATPase_N; Phospholipid-translocating ATPase N-terminal
      pfam16212
      Location:810 → 1049
      PhoLip_ATPase_C; Phospholipid-translocating P-type ATPase C-terminal
      cl21460
      Location:762 → 799
      HAD_like; Haloacid Dehalogenase-like Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P98205.1

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