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    ATGLR1.2 Glutamate receptor family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834895, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATGLR1.2
    Official Full Name
    Glutamate receptor family protein
    Primary source
    TAIR:AT5G48400
    Locus tag
    AT5G48400
    See related
    Araport:AT5G48400
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GLR1.2; GLUTAMATE RECEPTOR 1.2; MJE7.3; MJE7_3
    Summary
    member of Putative ligand-gated ion channel subunit family
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    Genomic context

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    See ATGLR1.2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    4
    Sequence:
    Chromosome: 5; NC_003076.8 (19616066..19619508)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene FRIGIDA-like protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene glutamate receptor 1.3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The glutamate receptors AtGLR1.2 and AtGLR1.3 increase cold tolerance by regulating jasmonate signaling in Arabidopsis thaliana. Zheng Y, et al. Biochem Biophys Res Commun, 2018 Dec 2. PMID 30392908
    2. Glutamate receptor-like genes form Ca2+ channels in pollen tubes and are regulated by pistil D-serine. Michard E, et al. Science, 2011 Apr 22. PMID 21415319
    3. The identity of plant glutamate receptors. Lacombe B, et al. Science, 2001 May 25. PMID 11379626
    4. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
    5. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtGLR1.2 and 1.3 positively enhance cold tolerance in Arabidopsis by activating endogenous jasmonate accumulation
      Title: The glutamate receptors AtGLR1.2 and AtGLR1.3 increase cold tolerance by regulating jasmonate signaling in Arabidopsis thaliana.
    2. findings show that glutamate receptor-like channels (GLRs) facilitate Ca(2+) influx across the plasma membrane, modulate apical [Ca(2+)](cyt) gradient, and consequently affect pollen tube growth and morphogenesis
      Title: Glutamate receptor-like genes form Ca2+ channels in pollen tubes and are regulated by pistil D-serine.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables intracellularly ligand-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Glutamate receptor family protein
    NP_199651.1
    • ATGLR1.2; FUNCTIONS IN: protein binding, intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Extracellular ligand-binding receptor (InterPro:IPR001828), Glutamate receptor-related (InterPro:IPR015683), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 1.3 (TAIR:AT5G48410.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_851155.1
    • ATGLR1.2; FUNCTIONS IN: protein binding, intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Extracellular ligand-binding receptor (InterPro:IPR001828), Glutamate receptor-related (InterPro:IPR015683), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 1.3 (TAIR:AT5G48410.1); Has 3010 Blast hits to 2965 proteins in 183 species: Archae - 3; Bacteria - 141; Metazoa - 2192; Fungi - 0; Plants - 596; Viruses - 0; Other Eukaryotes - 78 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      19616066..19619508
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180824.2 → NP_851155.1  Glutamate receptor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851155.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G945
      Conserved Domains (3) summary
      cd06366
      Location:41 → 407
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      pfam01094
      Location:55 → 387
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:440 → 738
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    2. NM_124215.2 → NP_199651.1  Glutamate receptor family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199651.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LGN3, Q9LV72
      UniProtKB/TrEMBL
      A0A654G945
      Conserved Domains (4) summary
      cd06366
      Location:41 → 407
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      cd13686
      Location:440 → 770
      GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold
      pfam00060
      Location:563 → 801
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 387
      ANF_receptor; Receptor family ligand binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LV72.1

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