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    PKP-BETA1 plastidic pyruvate kinase beta subunit 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835369, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PKP-BETA1
    Official Full Name
    plastidic pyruvate kinase beta subunit 1
    Primary source
    TAIR:AT5G52920
    Locus tag
    AT5G52920
    See related
    Araport:AT5G52920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MXC20.15; MXC20_15; PKP1; PKP2; PLASTIDIAL PYRUVATE KINASE 1; PLASTIDIAL PYRUVATE KINASE 2; plastidic pyruvate kinase beta subunit 1
    Summary
    encodes a dominant chloroplast pyruvate kinase beta subunit. Important for seed oil biosynthesis. Ubiquitously expressed, with significantly increased expression in maturing seeds. The mutant plant has wrinkled seeds, with a 50-70% reduction in seed fatty acid content.
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    Genomic context

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    See PKP-BETA1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    12
    Sequence:
    Chromosome: 5; NC_003076.8 (21463467..21466880)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene membrane-associated kinase regulator Neighboring gene timeless family protein Neighboring gene ncRNA Neighboring gene hypothetical protein (DUF295)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis seedlings deficient in a plastidic pyruvate kinase are unable to utilize seed storage compounds for germination and establishment. Andre C, et al. Plant Physiol, 2007 Dec. PMID 17965177, Free PMC Article
    2. Function of plastidial pyruvate kinases in seeds of Arabidopsis thaliana. Baud S, et al. Plant J, 2007 Nov. PMID 17892448
    3. Analysis of metabolic flux phenotypes for two Arabidopsis mutants with severe impairment in seed storage lipid synthesis. Lonien J, et al. Plant Physiol, 2009 Nov. PMID 19755540, Free PMC Article
    4. A heteromeric plastidic pyruvate kinase complex involved in seed oil biosynthesis in Arabidopsis. Andre C, et al. Plant Cell, 2007 Jun. PMID 17557808, Free PMC Article
    5. Enzymes of glycolysis are functionally associated with the mitochondrion in Arabidopsis cells. Giegé P, et al. Plant Cell, 2003 Sep. PMID 12953116, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mutant shows delayed germination and seedling establishment dependent on an exogenous sugar supply
      Title: Arabidopsis seedlings deficient in a plastidic pyruvate kinase are unable to utilize seed storage compounds for germination and establishment.
    2. exhibited significant expression in maturing seeds; results obtained outlined the importance of these plastidial pyruvate kinases for fatty acid synthesis and embryo development
      Title: Function of plastidial pyruvate kinases in seeds of Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_124670.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyruvate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in seed maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plastidic pyruvate kinase beta subunit 1
    NP_200104.1
    • plastidic pyruvate kinase beta subunit 1 (PKP-BETA1); FUNCTIONS IN: pyruvate kinase activity; INVOLVED IN: response to cadmium ion, glycolysis, seed development, fatty acid biosynthetic process, lipid metabolic process; LOCATED IN: mitochondrion, chloroplast, chloroplast stroma; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Pyruvate kinase, C-terminal-like (InterPro:IPR015795), Pyruvate kinase, active site (InterPro:IPR018209), Pyruvate kinase, beta-barrel-like (InterPro:IPR011037), Pyruvate kinase, alpha/beta (InterPro:IPR015794), Pyruvate/Phosphoenolpyruvate kinase, catalytic core (InterPro:IPR015813), Pyruvate kinase (InterPro:IPR001697), Pyruvate kinase, barrel (InterPro:IPR015793); BEST Arabidopsis thaliana protein match is: plastidial pyruvate kinase 3 (TAIR:AT1G32440.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21463467..21466880
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124670.3 → NP_200104.1  plastidic pyruvate kinase beta subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200104.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56XD5, Q56ZT8, Q570A3, Q94AG4, Q9FLW9
      UniProtKB/TrEMBL
      A0A178U9G2, A0A5S9YDR2, A0A654GBE5
      Conserved Domains (1) summary
      PLN02623
      Location:1 → 579
      PLN02623; pyruvate kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FLW9.1

    Gene LinkOut

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