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    SERAT1;1 serine acetyltransferase 1;1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835778, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SERAT1;1
    Official Full Name
    serine acetyltransferase 1;1
    Primary source
    TAIR:AT5G56760
    Locus tag
    AT5G56760
    See related
    Araport:AT5G56760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATSERAT1;1; MIK19.23; MIK19_23; SAT-52; SAT5; SERINE ACETYLTRANSFERASE; serine acetyltransferase 1;1; SERINE ACETYLTRANSFERASE 5; SERINE ACETYLTRANSFERASE 52
    Summary
    Encodes a cytosolic serine O-acetyltransferase involved in sulfur assimilation and cysteine biosynthesis. Expressed in the vascular system.
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    Genomic context

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    See SERAT1;1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (22961229..22962713, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene N-MYC downregulated-like 1 Neighboring gene transcription repressor-like protein Neighboring gene effector of transcription2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cysteine biosynthesis in higher plants: a new member of the Arabidopsis thaliana serine acetyltransferase small gene-family obtained by functional complementation of an Escherichia coli cysteine auxotroph. Howarth JR, et al. Biochim Biophys Acta, 1997 Feb 7. PMID 9048879
    2. Analysis of cytosolic and plastidic serine acetyltransferase mutants and subcellular metabolite distributions suggests interplay of the cellular compartments for cysteine biosynthesis in Arabidopsis. Krueger S, et al. Plant Cell Environ, 2009 Apr. PMID 19143986
    3. Isoform-dependent differences in feedback regulation and subcellular localization of serine acetyltransferase involved in cysteine biosynthesis from Arabidopsis thaliana. Noji M, et al. J Biol Chem, 1998 Dec 4. PMID 9830017
    4. Genomic and functional characterization of the oas gene family encoding O-acetylserine (thiol) lyases, enzymes catalyzing the final step in cysteine biosynthesis in Arabidopsis thaliana. Jost R, et al. Gene, 2000 Aug 8. PMID 10940562
    5. Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis. Watanabe M, et al. Plant Cell, 2008 Sep. PMID 18776059, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SERAT1;1 may play a major role during seed development.
      Title: Comparative genomics and reverse genetics analysis reveal indispensable functions of the serine acetyltransferase gene family in Arabidopsis.
    2. Cytosolic SERAT1.1 and plastidic SERAT2.1 do not contribute to cysteine biosynthesis.
      Title: Analysis of cytosolic and plastidic serine acetyltransferase mutants and subcellular metabolite distributions suggests interplay of the cellular compartments for cysteine biosynthesis in Arabidopsis.
    3. From the results of sensitivity to feedback regulation, subcellular localization and expression of mRNA analyses, each serine acetyltransferase (SATase) isoform seems to have its specific role for cysteine biosynthesis.
      Title: In silico assessment of gene function involved in cysteine biosynthesis in Arabidopsis: expression analysis of multiple isoforms of serine acetyltransferase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_125059.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables serine O-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine O-acetyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cysteine biosynthetic process from serine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine acetyltransferase 1;1
    NP_200487.1
    • serine acetyltransferase 1;1 (SERAT1;1); FUNCTIONS IN: serine O-acetyltransferase activity; INVOLVED IN: cysteine biosynthetic process from serine; LOCATED IN: cytosol; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Hexapeptide transferase, conserved site (InterPro:IPR018357), Serine O-acetyltransferase (InterPro:IPR005881), Trimeric LpxA-like (InterPro:IPR011004), Bacterial transferase hexapeptide repeat (InterPro:IPR001451), Serine acetyltransferase, N-terminal (InterPro:IPR010493); BEST Arabidopsis thaliana protein match is: serine acetyltransferase 2;2 (TAIR:AT3G13110.1); Has 18874 Blast hits to 18857 proteins in 2524 species: Archae - 292; Bacteria - 13784; Metazoa - 5; Fungi - 219; Plants - 250; Viruses - 18; Other Eukaryotes - 4306 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      22961229..22962713 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125059.3 → NP_200487.1  serine acetyltransferase 1;1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200487.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WSF3, Q42538, Q8LFG6
      UniProtKB/TrEMBL
      A0A5S9YEW3
      Conserved Domains (3) summary
      cd03354
      Location:176 → 276
      LbH_SAT; Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of ...
      PLN02694
      Location:1 → 312
      PLN02694; serine O-acetyltransferase
      pfam06426
      Location:46 → 148
      SATase_N; Serine acetyltransferase, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q42538.1

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