ACBP6 acyl-CoA-binding protein 6 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ACBP6
Official Full Name: acyl-CoA-binding protein 6
Primary source: TAIR:AT1G31812
Locus tag: AT1G31812
See related: Araport:AT1G31812
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ACBP; ACYL-COA-BINDING PROTEIN; acyl-CoA-binding protein 6; AtACBP6; F5M6.27; F5M6_27
Summary: Acyl-CoA-binding protein. Bind acyl-CoA esters and protect acyl-CoAs from degradation by microsomal acyl-hydrolases.
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Genomic context

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See ACBP6 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 4

Sequence:: Chromosome: 1; NC_003070.9 (11410766..11412233, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDLP8 may possibly influence AtACBP6 accumulation in the sieve elements.
Title: Arabidopsis thaliana Acyl-CoA-binding protein ACBP6 interacts with plasmodesmata-located protein PDLP8.
results suggest the involvement of AtACBP6 in JA-biosynthesis in Arabidopsis phloem tissues.
Title: Arabidopsis acyl-CoA-binding protein ACBP6 localizes in the phloem and affects jasmonate composition.
The roles of cytosolic AtACBP4, 5 and 6 in floral development were addressed in this study.
Title: The Arabidopsis cytosolic Acyl-CoA-binding proteins play combinatory roles in pollen development.
Data indicate that the acyl-CoA-binding proteins acbp4acbp5acbp6 mutant showed the lightest seed weight and highest sensitivity to abscisic acid during germination.
Title: Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development.
The mechanism in ACBP6-conferred freezing tolerance varies in different organs.
Title: Transgenic Arabidopsis flowers overexpressing acyl-CoA-binding protein ACBP6 are freezing tolerant.
Acyl-Coenzyme A-Binding Protein ACB6 enhances freezing tolerance. Histidine-tagged ACBP6 binds phosphatidylcholine, but not phosphatidic acid or lysophosphatidylcholine implying a role for ACBP6 in phospholipid metabolism in Arabidopsis. [ACBP6]
Title: Overexpression of the Arabidopsis 10-kilodalton acyl-coenzyme A-binding protein ACBP6 enhances freezing tolerance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_102916.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylcholine binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in response to absence of light	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to freezing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: acyl-CoA-binding protein 6

NP_174462.1

acyl-CoA-binding protein 6 (ACBP6); FUNCTIONS IN: phosphatidylcholine binding, acyl-CoA binding; INVOLVED IN: response to freezing, response to cold, lipid transport; LOCATED IN: cytosol, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 1 (TAIR:AT5G53470.1); Has 1828 Blast hits to 1828 proteins in 405 species: Archae - 0; Bacteria - 293; Metazoa - 888; Fungi - 180; Plants - 233; Viruses - 0; Other Eukaryotes - 234 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

11410766..11412233 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102916.4 → NP_174462.1 acyl-CoA-binding protein 6 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_174462.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P57752, Q8L9P1

UniProtKB/TrEMBL

A0A178WJ33, A0A5S9WM48

Conserved Domains (1) summary

cd00435
Location:3 → 87

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...