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    LARP1a LA RNA-binding protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832242, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LARP1a
    Official Full Name
    LA RNA-binding protein
    Primary source
    TAIR:AT5G21160
    Locus tag
    AT5G21160
    See related
    Araport:AT5G21160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtLARP1a; La related protein 1a; T10F18.190; T10F18_190
    Summary
    Encodes a protein with sequence similarity to mRNA binding proteins from humans. LARP1a is involved in mRNA degradation in response to heat stress. Upon heat stress LARP1a interacts with XRN4 and appears to be responsible for addressing XRN4 to the polysome. LARP1/XRN4 double mutants are impaired in thermotolerance and lower levels of heat induced RNA turnover.
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    Genomic context

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    See LARP1a in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    15
    Sequence:
    Chromosome: 5; NC_003076.8 (7198633..7204097, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene embryo defective 1379 Neighboring gene Argonaute family protein Neighboring gene miscRNA Neighboring gene 5'-AMP-activated protein kinase beta-2 subunit protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation. Scarpin MR, et al. Elife, 2020 Oct 15. PMID 33054972, Free PMC Article
    2. XRN4 and LARP1 are required for a heat-triggered mRNA decay pathway involved in plant acclimation and survival during thermal stress. Merret R, et al. Cell Rep, 2013 Dec 12. PMID 24332370
    3. Protein and metabolite composition of Arabidopsis stress granules. Kosmacz M, et al. New Phytol, 2019 May. PMID 30664249
    4. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article
    5. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation.
      Title: Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in translation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203425.1
    NM_001203426.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA cap binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-UTR binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular heat acclimation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of mRNA catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    LA RNA-binding protein
    NP_001190354.1
    • LA RNA-binding protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), RNA-binding protein Lupus La (InterPro:IPR006630), Protein of unknown function DM15 (InterPro:IPR006607); BEST Arabidopsis thaliana protein match is: winged-helix DNA-binding transcription factor family protein (TAIR:AT4G35890.1).
    NP_001190355.1
    • LA RNA-binding protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), RNA-binding protein Lupus La (InterPro:IPR006630), Protein of unknown function DM15 (InterPro:IPR006607); BEST Arabidopsis thaliana protein match is: winged-helix DNA-binding transcription factor family protein (TAIR:AT4G35890.1).
    NP_568409.1
    • LA RNA-binding protein; FUNCTIONS IN: molecular_function unknown; INVOLVED IN: biological_process unknown; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Winged helix-turn-helix transcription repressor DNA-binding (InterPro:IPR011991), RNA-binding protein Lupus La (InterPro:IPR006630), Protein of unknown function DM15 (InterPro:IPR006607); BEST Arabidopsis thaliana protein match is: winged-helix DNA-binding transcription factor family protein (TAIR:AT4G35890.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      7198633..7204097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122123.3 → NP_568409.1  LA RNA-binding protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568409.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q56WZ6, Q940X9
      UniProtKB/TrEMBL
      A0A654G2Y7
      Conserved Domains (2) summary
      smart00684
      Location:712 → 749
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd07323
      Location:279 → 351
      LAM; LA motif RNA-binding domain

    2. NM_001203426.1 → NP_001190355.1  LA RNA-binding protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190355.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G2Y7, F4K703
      Conserved Domains (2) summary
      smart00684
      Location:712 → 749
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd07323
      Location:279 → 351
      LAM; LA motif RNA-binding domain

    3. NM_001203425.1 → NP_001190354.1  LA RNA-binding protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654G2Y7, F4K704
      Conserved Domains (2) summary
      smart00684
      Location:712 → 749
      DM15; Tandem repeat in fly CG14066 (La related protein), human KIAA0731 and worm R144.7. Unknown function
      cd07323
      Location:279 → 351
      LAM; LA motif RNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q940X9.1

    Gene LinkOut

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