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    NUDX23 nudix hydrolase homolog 23 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818807, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NUDX23
    Official Full Name
    nudix hydrolase homolog 23
    Primary source
    TAIR:AT2G42070
    Locus tag
    AT2G42070
    See related
    Araport:AT2G42070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA NUDIX HYDROLASE HOMOLOG 23; ATNUDT23; ATNUDX23; nudix hydrolase homolog 23; T6D20.4; T6D20_4
    Summary
    Encodes a plastid-localized Nudix hydrolase that has FAD pyrophosphohydrolase activity. Negative feedback regulation of the metabolism of flavins through the hydrolysis of FAD by AtNUDX23 in plastids is involved in the flavin homeostasis in plant cells.
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    Genomic context

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    See NUDX23 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (17549091..17551364, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene WRC protein Neighboring gene pseudo Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene DnaJ domain protein Neighboring gene Chaperone DnaJ-domain superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Arabidopsis FAD pyrophosphohydrolase, AtNUDX23, is involved in flavin homeostasis. Maruta T, et al. Plant Cell Physiol, 2012 Jun. PMID 22505691
    2. Molecular characterization of organelle-type Nudix hydrolases in Arabidopsis. Ogawa T, et al. Plant Physiol, 2008 Nov. PMID 18815383, Free PMC Article
    3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_001336950.1
    NM_129770.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP-ribose diphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within flavin-containing compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    nudix hydrolase homolog 23
    NP_565965.1
    • nudix hydrolase homolog 23 (NUDX23); CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase (InterPro:IPR020476), NUDIX hydrolase, conserved site (InterPro:IPR020084), NUDIX hydrolase domain (InterPro:IPR000086); Has 7171 Blast hits to 7171 proteins in 1678 species: Archae - 149; Bacteria - 5807; Metazoa - 107; Fungi - 42; Plants - 74; Viruses - 1; Other Eukaryotes - 991 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      17549091..17551364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129770.4 → NP_565965.1  nudix hydrolase homolog 23 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565965.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P93740, Q1ECD1, Q8LAH1
      UniProtKB/TrEMBL
      A0A178VYY0, A0A5S9X685, A0A654F6E1
      Conserved Domains (2) summary
      cd04511
      Location:110 → 239
      Nudix_Hydrolase_4; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
      pfam14803
      Location:86 → 116
      Nudix_N_2; Nudix N-terminal

    2. NM_001336950.1 → NP_001324265.1  nudix hydrolase homolog 23 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZL7, A0A5S9X685, A0A654F6E1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P93740.2

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