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    SMO2-2 sterol 4-alpha-methyl-oxidase 2-2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817488, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SMO2-2
    Official Full Name
    sterol 4-alpha-methyl-oxidase 2-2
    Primary source
    TAIR:AT2G29390
    Locus tag
    AT2G29390
    See related
    Araport:AT2G29390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana sterol 4-alpha-methyl-oxidase 2-2; ATSMO2; ATSMO2-2; F16P2.23; F16P2_23; STEROL 4-ALPHA-METHYL-OXIDASE 2; sterol 4-alpha-methyl-oxidase 2-2
    Summary
    Encodes a sterol 4-alpha-methyl-oxidase, specifically a 4-alpha-methyl-delta-7-sterol-4alpha-methyl-oxidase.
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    Genomic context

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    See SMO2-2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (12610508..12612937, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene highly ABA-induced PP2C protein 3 Neighboring gene type one protein phosphatase 1 Neighboring gene metal tolerance protein B1 Neighboring gene glutathione S-transferase tau 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sterol Methyl Oxidases Affect Embryo Development via Auxin-Associated Mechanisms. Zhang X, et al. Plant Physiol, 2016 May. PMID 27006488, Free PMC Article
    2. Functional identification of sterol-4alpha-methyl oxidase cDNAs from Arabidopsis thaliana by complementation of a yeast erg25 mutant lacking sterol-4alpha-methyl oxidation. Darnet S, et al. FEBS Lett, 2001 Nov 9. PMID 11707264
    3. Plant sterol biosynthesis: identification of two distinct families of sterol 4alpha-methyl oxidases. Darnet S, et al. Biochem J, 2004 Mar 15. PMID 14653780, Free PMC Article
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084505.1
    NM_001084506.1
    NM_001336210.1
    NM_128493.4
    NM_179802.3
    NM_201830.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables C-4 methylsterol oxidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within 4-alpha-methyl-delta7-sterol oxidation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sterol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sterol 4-alpha-methyl-oxidase 2-2
    NP_001077975.1
    • sterol 4-alpha-methyl-oxidase 2-2; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sterol 4-alpha-methyl-oxidase 2-1 (TAIR:AT1G07420.1); Has 2759 Blast hits to 2754 proteins in 480 species: Archae - 0; Bacteria - 620; Metazoa - 428; Fungi - 656; Plants - 468; Viruses - 3; Other Eukaryotes - 584 (source: NCBI BLink).
    NP_001318311.1
    • sterol 4-alpha-methyl-oxidase 2-2; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sterol 4-alpha-methyl-oxidase 2-1 (TAIR:AT1G07420.1); Has 2673 Blast hits to 2668 proteins in 451 species: Archae - 0; Bacteria - 552; Metazoa - 427; Fungi - 653; Plants - 468; Viruses - 3; Other Eukaryotes - 570 (source: NCBI BLink).
    NP_565681.1
    • sterol 4-alpha-methyl-oxidase 2-2 (SMO2-2); CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sterol 4-alpha-methyl-oxidase 2-1 (TAIR:AT1G07420.1); Has 2545 Blast hits to 2540 proteins in 425 species: Archae - 0; Bacteria - 475; Metazoa - 426; Fungi - 627; Plants - 480; Viruses - 3; Other Eukaryotes - 534 (source: NCBI BLink).
    NP_850133.1
    • sterol 4-alpha-methyl-oxidase 2-2; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sterol 4-alpha-methyl-oxidase 2-1 (TAIR:AT1G07420.1); Has 2780 Blast hits to 2775 proteins in 484 species: Archae - 0; Bacteria - 626; Metazoa - 432; Fungi - 682; Plants - 470; Viruses - 3; Other Eukaryotes - 567 (source: NCBI BLink).
    NP_973559.1
    • sterol 4-alpha-methyl-oxidase 2-2; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sterol 4-alpha-methyl-oxidase 2-1 (TAIR:AT1G07420.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12610508..12612937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179802.3 → NP_850133.1  sterol 4-alpha-methyl-oxidase 2-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850133.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VWC7, A0A5S9X2F0
      Conserved Domains (1) summary
      pfam04116
      Location:112 → 247
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    2. NM_128493.4 → NP_565681.1  sterol 4-alpha-methyl-oxidase 2-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565681.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MQF7, A8MRF1, F4IKN2, Q8W5A2, Q8W5B3, Q9ZW22
      UniProtKB/TrEMBL
      A0A5S9X2F0
      Conserved Domains (2) summary
      COG3000
      Location:72 → 259
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:112 → 259
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    3. NM_001336210.1 → NP_001318311.1  sterol 4-alpha-methyl-oxidase 2-2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZW22
      Conserved Domains (2) summary
      COG3000
      Location:17 → 164
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:29 → 164
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    4. NM_201830.2 → NP_973559.1  sterol 4-alpha-methyl-oxidase 2-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973559.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VXN6, A0A5S9X2F0
      Conserved Domains (1) summary
      pfam04116
      Location:105 → 240
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    5. NM_001084505.1 → NP_001077974.1  sterol 4-alpha-methyl-oxidase 2-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077974.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZW22
      Conserved Domains (2) summary
      COG3000
      Location:17 → 164
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:29 → 164
      FA_hydroxylase; Fatty acid hydroxylase superfamily

    6. NM_001084506.1 → NP_001077975.1  sterol 4-alpha-methyl-oxidase 2-2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077975.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZW22
      Conserved Domains (2) summary
      COG3000
      Location:31 → 206
      ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
      pfam04116
      Location:71 → 206
      FA_hydroxylase; Fatty acid hydroxylase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZW22.2

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