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    SCA3 DNA/RNA polymerases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816946, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SCA3
    Official Full Name
    DNA/RNA polymerases superfamily protein
    Primary source
    TAIR:AT2G24120
    Locus tag
    AT2G24120
    See related
    Araport:AT2G24120
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F27D4.3; F27D4_3; PDE319; PIGMENT DEFECTIVE 319; SCABRA 3
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    Genomic context

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    See SCA3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    19
    Sequence:
    Chromosome: 2; NC_003071.7 (10248851..10254641, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ATP-dependent DNA helicase Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Leucine-rich receptor-like protein kinase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [Analysis of SCA3/MJD3 gene mutation and genetic polymorphism in a guangxi family with spinocerebellar ataxia 3]. Chang RN, et al. Yi Chuan, 2013 Nov. PMID 24579313
    2. The SCABRA3 nuclear gene encodes the plastid RpoTp RNA polymerase, which is required for chloroplast biogenesis and mesophyll cell proliferation in Arabidopsis. Hricová A, et al. Plant Physiol, 2006 Jul. PMID 16698900, Free PMC Article
    3. Impaired function of the phage-type RNA polymerase RpoTp in transcription of chloroplast genes is compensated by a second phage-type RNA polymerase. Swiatecka-Hagenbruch M, et al. Nucleic Acids Res, 2008 Feb. PMID 18084023, Free PMC Article
    4. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
    5. Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins. Heazlewood JL, et al. Plant Cell, 2004 Jan. PMID 14671022, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exon 10 of the SCA3 gene contains 64-71 CAG repeats in all of the affected individuals.
      Title: [Analysis of SCA3/MJD3 gene mutation and genetic polymorphism in a guangxi family with spinocerebellar ataxia 3].
    2. evidence for nuclear-encoded RNA polymerases being represented by two phage-type RNA polymerases (RpoTp and RpoTmp) that have overlapping as well as gene-specific functions in the transcription of plastidial genes.
      Title: Impaired function of the phage-type RNA polymerase RpoTp in transcription of chloroplast genes is compensated by a second phage-type RNA polymerase.
    3. findings support a role for plastids in leaf morphogenesis and indicates that RpoTp is required for mesophyll cell proliferation
      Title: The SCABRA3 nuclear gene encodes the plastid RpoTp RNA polymerase, which is required for chloroplast biogenesis and mesophyll cell proliferation in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_127973.5
    NM_201796.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    DNA/RNA polymerases superfamily protein
    NP_179989.1
    • SCABRA 3 (SCA3); FUNCTIONS IN: DNA-directed RNA polymerase activity, protein binding, DNA binding; INVOLVED IN: transcription; LOCATED IN: mitochondrion; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA-directed RNA polymerase, bacteriophage type (InterPro:IPR002092); BEST Arabidopsis thaliana protein match is: male gametophyte defective 3 (TAIR:AT1G68990.1); Has 1315 Blast hits to 1296 proteins in 334 species: Archae - 0; Bacteria - 38; Metazoa - 134; Fungi - 224; Plants - 204; Viruses - 139; Other Eukaryotes - 576 (source: NCBI BLink).
    NP_973525.2
    • SCABRA 3 (SCA3); FUNCTIONS IN: DNA-directed RNA polymerase activity, protein binding, DNA binding; INVOLVED IN: transcription; LOCATED IN: mitochondrion; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: DNA-directed RNA polymerase, bacteriophage type (InterPro:IPR002092); BEST Arabidopsis thaliana protein match is: male gametophyte defective 3 (TAIR:AT1G68990.1); Has 1200 Blast hits to 1186 proteins in 332 species: Archae - 0; Bacteria - 40; Metazoa - 130; Fungi - 220; Plants - 200; Viruses - 136; Other Eukaryotes - 474 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10248851..10254641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127973.5 → NP_179989.1  DNA/RNA polymerases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179989.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O24600, Q0WN04
      UniProtKB/TrEMBL
      A0A5S9X0T4, A0A654EVL5
      Conserved Domains (2) summary
      COG5108
      Location:162 → 992
      RPO41; Mitochondrial DNA-directed RNA polymerase [Transcription]
      pfam00940
      Location:602 → 992
      RNA_pol; DNA-dependent RNA polymerase

    2. NM_201796.2 → NP_973525.2  DNA/RNA polymerases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973525.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W214, F4INQ5
      Conserved Domains (2) summary
      pfam00940
      Location:602 → 879
      RNA_pol; DNA-dependent RNA polymerase
      pfam14700
      Location:165 → 478
      RPOL_N; DNA-directed RNA polymerase N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O24600.1

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