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    ALKBH2 oxidoreductase, 2OG-Fe(II) oxygenase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816759, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ALKBH2
    Official Full Name
    oxidoreductase, 2OG-Fe(II) oxygenase family protein
    Primary source
    TAIR:AT2G22260
    Locus tag
    AT2G22260
    See related
    Araport:AT2G22260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    homolog of E. coli alkB; T26C19.8; T26C19_8
    Summary
    Encodes a homolog of the E. coli AlkB gene, whose protein product is a DNA repair enzyme important in reversing methylation damage.
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    Genomic context

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    See ALKBH2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (9460918..9463561)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Thioesterase superfamily protein Neighboring gene myo-inositol-1-phosphate synthase 2 Neighboring gene uncharacterized protein Neighboring gene aspartate aminotransferase Neighboring gene hematological/neurological-like protein Neighboring gene tRNA-Arg

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Meza TJ, et al. Nucleic Acids Res, 2012 Aug. PMID 22532610, Free PMC Article
    2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001335789.1
    NM_001335790.1
    NM_001335791.1
    NM_001335792.1
    NM_001335793.1
    NM_127792.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA demethylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    oxidoreductase, 2OG-Fe(II) oxygenase family protein
    NP_565530.1
    • oxidoreductase, 2OG-Fe(II) oxygenase family protein; FUNCTIONS IN: oxidoreductase activity; INVOLVED IN: metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oxoglutarate/iron-dependent oxygenase (InterPro:IPR005123); BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT2G22270.1); Has 1561 Blast hits to 1561 proteins in 515 species: Archae - 0; Bacteria - 839; Metazoa - 118; Fungi - 181; Plants - 86; Viruses - 14; Other Eukaryotes - 323 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9460918..9463561
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335786.1 → NP_001325000.1  oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIE0
      UniProtKB/TrEMBL
      A0A654EV15

    2. NM_001335788.1 → NP_001324999.1  oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIE0
      UniProtKB/TrEMBL
      A0A654EV15

    3. NM_001335787.1 → NP_001324995.1  oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1U3

    4. NM_127792.4 → NP_565530.1  oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565530.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIE0
      UniProtKB/TrEMBL
      A0A654EV15
      Conserved Domains (2) summary
      pfam13266
      Location:7 → 63
      DUF4057; Protein of unknown function (DUF4057)
      cl21496
      Location:106 → 311
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    5. NM_001335789.1 → NP_001324998.1  oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SIE0
      UniProtKB/TrEMBL
      A0A654EV15

    6. NM_001335790.1 → NP_001324997.1  oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VU09, A0A1P8B1V2, A0A5S9X059

    7. NM_001335791.1 → NP_001324996.1  oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1U3

    8. NM_001335792.1 → NP_001324994.1  oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1U3

    9. NM_001335793.1 → NP_001324993.1  oxidoreductase, 2OG-Fe(II) oxygenase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B1T8, A0A654EV15
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SIE0.2

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