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    APK2A protein kinase 2A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837999, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APK2A
    Official Full Name
    protein kinase 2A
    Primary source
    TAIR:AT1G14370
    Locus tag
    AT1G14370
    See related
    Araport:AT1G14370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F14L17.14; F14L17_14; Kin1; kinase 1; PBL2; PBS1-like 2; protein kinase 2A; PROTEIN KINASE 2A
    Summary
    Encodes protein kinase APK2a. Protein is N-myristoylated.
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    Genomic context

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    See APK2A in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (4915491..4918138)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Duplicated homeodomain-like superfamily protein Neighboring gene UDP-galactose transporter 3 Neighboring gene ncRNA Neighboring gene IQ-domain 28 Neighboring gene ncRNA Neighboring gene Leucine-rich repeat protein kinase family protein Neighboring gene ubiquitin carrier protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ligand-triggered allosteric ADP release primes a plant NLR complex. Wang J, et al. Science, 2019 Apr 5. PMID 30948526
    2. xopAC-triggered immunity against Xanthomonas depends on Arabidopsis receptor-like cytoplasmic kinase genes PBL2 and RIPK. Guy E, et al. PLoS One, 2013. PMID 23951354, Free PMC Article
    3. Receptor-like cytoplasmic kinases integrate signaling from multiple plant immune receptors and are targeted by a Pseudomonas syringae effector. Zhang J, et al. Cell Host Microbe, 2010 Apr 22. PMID 20413097
    4. Protein N-acylation overrides differing targeting signals. Stael S, et al. FEBS Lett, 2011 Feb 4. PMID 21219905, Free PMC Article
    5. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Popescu SC, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360592, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. xopAC-triggered immunity against Xanthomonas depends on Arabidopsis receptor-like cytoplasmic kinase genes PBL2 and RIPK.
      Title: xopAC-triggered immunity against Xanthomonas depends on Arabidopsis receptor-like cytoplasmic kinase genes PBL2 and RIPK.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101304.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables Tat protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase 2A
    NP_172889.1
    • protein kinase 2A (APK2A); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: chloroplast; EXPRESSED IN: 17 plant structures; EXPRESSED DURING: 9 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: protein kinase 2B (TAIR:AT2G02800.2); Has 112844 Blast hits to 111359 proteins in 3847 species: Archae - 89; Bacteria - 13219; Metazoa - 41419; Fungi - 9318; Plants - 32676; Viruses - 341; Other Eukaryotes - 15782 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4915491..4918138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101304.4 → NP_172889.1  protein kinase 2A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172889.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49839
      UniProtKB/TrEMBL
      A0A178WI52, A0A654EAT2
      Conserved Domains (1) summary
      cd14066
      Location:92 → 369
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49839.1

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