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    MAC5A CCCH-type zinc fingerfamily protein with RNA-binding domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837248, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MAC5A
    Official Full Name
    CCCH-type zinc fingerfamily protein with RNA-binding domain-containing protein
    Primary source
    TAIR:AT1G07360
    Locus tag
    AT1G07360
    See related
    Araport:AT1G07360
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22G5.30; F22G5_30; MOS4-associated complex subunit 5A
    Summary
    Encodes MAC5A, a component of the MOS4-associated complex (MAC) that contributes to snc1- mediated autoimmunity. MAC is a highly conserved nuclear protein complex associated with the spliceosome. Homologues include AT1G07360 (MAC5A), AT2G29580 (MAC5B) and AT5G07060 (MAC5C).
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    Genomic context

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    See MAC5A in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (2260317..2262923, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene sugar transporter 2 Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene proliferating cellular nuclear antigen 1 Neighboring gene Neutral/alkaline non-lysosomal ceramidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA-binding protein MAC5A interacts with the 26S proteasome to regulate DNA damage response in Arabidopsis. Meng X, et al. Plant Physiol, 2023 Jan 2. PMID 36331331, Free PMC Article
    2. Two putative RNA-binding proteins function with unequal genetic redundancy in the MOS4-associated complex. Monaghan J, et al. Plant Physiol, 2010 Dec. PMID 20943852, Free PMC Article
    3. Recruitment of the NineTeen Complex to the activated spliceosome requires AtPRMT5. Deng X, et al. Proc Natl Acad Sci U S A, 2016 May 10. PMID 27114555, Free PMC Article
    4. Arabidopsis ACINUS is O-glycosylated and regulates transcription and alternative splicing of regulators of reproductive transitions. Bi Y, et al. Nat Commun, 2021 Feb 11. PMID 33574257, Free PMC Article
    5. In Planta Determination of the mRNA-Binding Proteome of Arabidopsis Etiolated Seedlings. Reichel M, et al. Plant Cell, 2016 Oct. PMID 27729395, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RNA-binding protein MAC5A interacts with the 26S proteasome to regulate DNA damage response in Arabidopsis.
      Title: RNA-binding protein MAC5A interacts with the 26S proteasome to regulate DNA damage response in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_100610.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    CCCH-type zinc fingerfamily protein with RNA-binding domain-containing protein
    NP_563788.1
    • CCCH-type zinc fingerfamily protein with RNA-binding domain; FUNCTIONS IN: RNA binding, nucleotide binding, zinc ion binding, nucleic acid binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, CCCH-type (InterPro:IPR000571), RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: CCCH-type zinc fingerfamily protein with RNA-binding domain (TAIR:AT2G29580.1); Has 18250 Blast hits to 13471 proteins in 794 species: Archae - 12; Bacteria - 1319; Metazoa - 6997; Fungi - 3518; Plants - 3570; Viruses - 267; Other Eukaryotes - 2567 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      2260317..2262923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100610.4 → NP_563788.1  CCCH-type zinc fingerfamily protein with RNA-binding domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563788.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93XZ5, Q9LNV5
      UniProtKB/TrEMBL
      A0A178WG41
      Conserved Domains (3) summary
      smart00356
      Location:157 → 181
      ZnF_C3H1; zinc finger
      COG0724
      Location:210 → 305
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12224
      Location:227 → 300
      RRM_RBM22; RNA recognition motif (RRM) found in Pre-mRNA-splicing factor RBM22 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LNV5.1

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