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    Nmt2 N-myristoyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 18108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nmt2provided by MGI
    Official Full Name
    N-myristoyltransferase 2provided by MGI
    Primary source
    MGI:MGI:1202298
    See related
    Ensembl:ENSMUSG00000026643 AllianceGenome:MGI:1202298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hNMT-2; A930001K02Rik
    Summary
    Predicted to enable glycylpeptide N-tetradecanoyltransferase activity and peptidyl-lysine N6-myristoyltransferase activity. Predicted to be involved in N-terminal peptidyl-glycine N-myristoylation and protein localization to membrane. Predicted to act upstream of or within N-terminal protein myristoylation. Predicted to be located in Golgi apparatus and plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including central nervous system; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human NMT2 (N-myristoyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 16.8), CNS E18 (RPKM 14.5) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nmt2 in Genome Data Viewer
    Location:
    2 A1; 2 1.84 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3285249..3329914)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3284212..3328877)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_03510 Neighboring gene family with sequence similarity 171, member A1 Neighboring gene predicted gene, 54098 Neighboring gene STARR-seq mESC enhancer starr_03511 Neighboring gene predicted gene, 22005 Neighboring gene STARR-positive B cell enhancer ABC_E999 Neighboring gene ribonuclease P/MRP 38 subunit Neighboring gene acyl-Coenzyme A binding domain containing 7 Neighboring gene oleoyl-ACP hydrolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Immunosuppression and Aberrant T Cell Development in the Absence of N-Myristoylation. Rampoldi F, et al. J Immunol, 2015 Nov 1. PMID 26423150
    2. N-myristoyltransferase 1 is essential in early mouse development. Yang SH, et al. J Biol Chem, 2005 May 13. PMID 15753093
    3. Deficiency of N-myristoylation reveals calcineurin activity as regulator of IFN-γ-producing γδ T cells. Rampoldi F, et al. J Leukoc Biol, 2017 Apr. PMID 28062573
    4. Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis. Ducker CE, et al. Mol Cancer Res, 2005 Aug. PMID 16123142, Free PMC Article
    5. The biology and enzymology of protein N-myristoylation. Farazi TA, et al. J Biol Chem, 2001 Oct 26. PMID 11527981

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NMT1 and NMT2 have only partially overlapping functions; NMT1 is critical for tumor cell proliferation
      Title: Two N-myristoyltransferase isozymes play unique roles in protein myristoylation, proliferation, and apoptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glycylpeptide N-tetradecanoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables glycylpeptide N-tetradecanoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycylpeptide N-tetradecanoyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables peptidyl-lysine N6-myristoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidyl-lysine N6-myristoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within N-terminal peptidyl-glycine N-myristoylation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in N-terminal peptidyl-glycine N-myristoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-terminal peptidyl-glycine N-myristoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within N-terminal protein myristoylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glycylpeptide N-tetradecanoyltransferase 2
    Names
    myristoyl-CoA:protein N-myristoyltransferase 2
    peptide N-myristoyltransferase 2
    type II N-myristoyltransferase
    NP_001277297.1
    NP_001277298.1
    NP_001277299.1
    NP_032734.1
    XP_036015249.1
    XP_036015250.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290368.1 → NP_001277297.1  glycylpeptide N-tetradecanoyltransferase 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK161490, AL732620, AL928883
      Conserved Domains (2) summary
      pfam01233
      Location:133 → 287
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:303 → 478
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    2. NM_001290369.1 → NP_001277298.1  glycylpeptide N-tetradecanoyltransferase 2 isoform c

      See identical proteins and their annotated locations for NP_001277298.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon that results in translation initiation at an alternate start codon and a frameshifted 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AK134521, AL732620, AL928883
      Consensus CDS
      CCDS70972.1
      UniProtKB/TrEMBL
      F7APP3
      Related
      ENSMUSP00000089085.5, ENSMUST00000091504.5
      Conserved Domains (2) summary
      pfam01233
      Location:127 → 281
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:297 → 472
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    3. NM_001290370.1 → NP_001277299.1  glycylpeptide N-tetradecanoyltransferase 2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons that result in the loss of an in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
      Source sequence(s)
      AK134521, AL732620, AL928883
      Consensus CDS
      CCDS70971.1
      UniProtKB/TrEMBL
      A2AJH3
      Related
      ENSMUSP00000100054.4, ENSMUST00000102989.10
      Conserved Domains (2) summary
      pfam01233
      Location:140 → 294
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:310 → 485
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    4. NM_008708.2 → NP_032734.1  glycylpeptide N-tetradecanoyltransferase 2 isoform a

      See identical proteins and their annotated locations for NP_032734.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK134521, AL732620, AL928883
      Consensus CDS
      CCDS15644.1
      UniProtKB/Swiss-Prot
      O70311
      UniProtKB/TrEMBL
      Q3THR4
      Related
      ENSMUSP00000080600.7, ENSMUST00000081932.13
      Conserved Domains (2) summary
      pfam01233
      Location:171 → 325
      NMT; Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain
      pfam02799
      Location:341 → 516
      NMT_C; Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      3285249..3329914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159357.1 → XP_036015250.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X2

      Conserved Domains (1) summary
      COG5092
      Location:22 → 389
      NMT1; N-myristoyl transferase [Lipid metabolism]

    2. XM_036159356.1 → XP_036015249.1  glycylpeptide N-tetradecanoyltransferase 2 isoform X1

      Conserved Domains (1) summary
      COG5092
      Location:55 → 422
      NMT1; N-myristoyl transferase [Lipid metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70311.1 GenPept UniProtKB/Swiss-Prot:O70311

    Gene LinkOut

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