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    ATWHY2 WHIRLY 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 843467, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATWHY2
    Official Full Name
    WHIRLY 2
    Primary source
    TAIR:AT1G71260
    Locus tag
    AT1G71260
    See related
    Araport:AT1G71260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F3I17.9; F3I17_9; WHIRLY 2; WHY2
    Summary
    Encodes WHY2, a homolog of the potato p24 protein. It shares the conserved KGKAAL domain, a putative DNA-binding domain, with potato p24 and is localized to mitochondria and not the nucleus. WHY2 is a member of the Whirly family proteins present mainly in the plant kingdom performing various activities related to DNA metabolism. Crystal structure of Solanum tuberosum WHY2, a close homolog of Arabidopsis WHY2, reveal that Whirly proteins bind to single strand DNA to promote accurate repair of DNA double-strand breaks over an error-prone repair pathway.
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    Genomic context

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    See ATWHY2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    8
    Sequence:
    Chromosome: 1; NC_003070.9 (26861657..26863454, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene chromosome-partitioning protein, putative (DUF639) Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene ncRNA Neighboring gene Vps52 / Sac2 family Neighboring gene DEA(D/H)-box RNA helicase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WHIRLY2 plays a key role in mitochondria morphology, dynamics, and functionality in Arabidopsis thaliana. Golin S, et al. Plant Direct, 2020 May. PMID 32490348, Free PMC Article
    2. Elevation of Pollen Mitochondrial DNA Copy Number by WHIRLY2: Altered Respiration and Pollen Tube Growth in Arabidopsis. Cai Q, et al. Plant Physiol, 2015 Sep. PMID 26195569, Free PMC Article
    3. Overexpression of mtDNA-associated AtWhy2 compromises mitochondrial function. Maréchal A, et al. BMC Plant Biol, 2008 Apr 18. PMID 18423020, Free PMC Article
    4. Crystal structures of DNA-Whirly complexes and their role in Arabidopsis organelle genome repair. Cappadocia L, et al. Plant Cell, 2010 Jun. PMID 20551348, Free PMC Article
    5. DNA-binding proteins of the Whirly family in Arabidopsis thaliana are targeted to the organelles. Krause K, et al. FEBS Lett, 2005 Jul 4. PMID 15967440

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtWHY2 affects mtDNA copy number in pollen and suggest that low mtDNA copy numbers might be the normal means by which plant cells maintain mitochondrial genetic information.[AtWHIRLY2]
      Title: Elevation of Pollen Mitochondrial DNA Copy Number by WHIRLY2: Altered Respiration and Pollen Tube Growth in Arabidopsis.
    2. AtWhy2 is associated with mtDNA and its overexpression results in the production of dysfunctional mitochondria.
      Title: Overexpression of mtDNA-associated AtWhy2 compromises mitochondrial function.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_105795.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WHIRLY 2
    NP_177282.2
    • WHIRLY 2 (ATWHY2); CONTAINS InterPro DOMAIN/s: ssDNA-binding transcriptional regulator (InterPro:IPR009044), Plant transcription factor (InterPro:IPR013742); BEST Arabidopsis thaliana protein match is: ssDNA-binding transcriptional regulator (TAIR:AT1G14410.1); Has 105 Blast hits to 105 proteins in 29 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 90; Viruses - 0; Other Eukaryotes - 15 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      26861657..26863454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105795.5 → NP_177282.2  WHIRLY 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_177282.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8VYF7, Q9FVV2
      UniProtKB/TrEMBL
      A0A178W9L5, A0A5S9WT41, A0A654EN31
      Conserved Domains (1) summary
      pfam08536
      Location:60 → 195
      Whirly; Whirly transcription factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VYF7.1

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