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    WSIP2 WUS-interacting protein 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820831, updated on 18-Sep-2024

    Summary

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    Official Symbol
    WSIP2
    Official Full Name
    WUS-interacting protein 2
    Primary source
    TAIR:AT3G15880
    Locus tag
    AT3G15880
    See related
    Araport:AT3G15880
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    TOPLESS-RELATED 4; TPR4; WUS-interacting protein 2
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    Genomic context

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    See WSIP2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    27
    Sequence:
    Chromosome: 3; NC_003074.8 (5364081..5372293, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene fatty acid desaturase 5 Neighboring gene plant self-incompatibility protein S1 family protein Neighboring gene Fatty acid desaturase family protein Neighboring gene Protein kinase superfamily protein Neighboring gene homoserine O-acetyltransferase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the transcription factor WUSCHEL and its functional homologue in Antirrhinum reveals a potential mechanism for their roles in meristem maintenance. Kieffer M, et al. Plant Cell, 2006 Mar. PMID 16461579, Free PMC Article
    2. TOPLESS mediates brassinosteroid-induced transcriptional repression through interaction with BZR1. Oh E, et al. Nat Commun, 2014 Jun 18. PMID 24938363, Free PMC Article
    3. TOPLESS regulates apical embryonic fate in Arabidopsis. Long JA, et al. Science, 2006 Jun 9. PMID 16763149
    4. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Fukazawa J, et al. Plant Cell, 2014 Jul. PMID 25035403, Free PMC Article
    5. The molecular mechanism of sporocyteless/nozzle in controlling Arabidopsis ovule development. Wei B, et al. Cell Res, 2015 Jan. PMID 25378179, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001202976.1
    NM_001338190.1
    NM_112458.5
    NM_180672.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in gibberellic acid homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of gibberellic acid mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within primary shoot apical meristem specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    WUS-interacting protein 2
    NP_001189905.1
    • WUS-interacting protein 2 (WSIP2); FUNCTIONS IN: protein binding; INVOLVED IN: primary shoot apical meristem specification; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), CTLH, C-terminal LisH motif (InterPro:IPR006595), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin family protein / WD-40 repeat family protein (TAIR:AT1G15750.4).
    NP_188209.3
    • WUS-interacting protein 2 (WSIP2); FUNCTIONS IN: protein binding; INVOLVED IN: primary shoot apical meristem specification; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), CTLH, C-terminal LisH motif (InterPro:IPR006595), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin family protein / WD-40 repeat family protein (TAIR:AT1G15750.4); Has 22596 Blast hits to 13790 proteins in 615 species: Archae - 20; Bacteria - 4432; Metazoa - 7625; Fungi - 4980; Plants - 2394; Viruses - 0; Other Eukaryotes - 3145 (source: NCBI BLink).
    NP_851003.2
    • WUS-interacting protein 2 (WSIP2); FUNCTIONS IN: protein binding; INVOLVED IN: primary shoot apical meristem specification; LOCATED IN: endomembrane system; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), CTLH, C-terminal LisH motif (InterPro:IPR006595), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), LisH dimerisation motif (InterPro:IPR006594), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin family protein / WD-40 repeat family protein (TAIR:AT1G15750.4); Has 22632 Blast hits to 13797 proteins in 616 species: Archae - 20; Bacteria - 4458; Metazoa - 7628; Fungi - 4973; Plants - 2405; Viruses - 0; Other Eukaryotes - 3148 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5364081..5372293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112458.5 → NP_188209.3  WUS-interacting protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188209.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XCI3
      Conserved Domains (5) summary
      smart00667
      Location:4 → 34
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:34 → 92
      CTLH; C-terminal to LisH motif
      COG2319
      Location:361 → 967
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:360 → 417
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:349 → 669
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_180672.4 → NP_851003.2  WUS-interacting protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851003.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHS5, Q0WMG2, Q27GK7, Q3EB60, Q9LVZ2
      UniProtKB/TrEMBL
      A0A178VJ72, A0A5S9XCI3
      Conserved Domains (4) summary
      smart00667
      Location:4 → 34
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:34 → 92
      CTLH; C-terminal to LisH motif
      sd00039
      Location:362 → 417
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:349 → 669
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001202976.1 → NP_001189905.1  WUS-interacting protein 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189905.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XCI3, F4J043
      Conserved Domains (5) summary
      smart00667
      Location:4 → 34
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:34 → 92
      CTLH; C-terminal to LisH motif
      COG2319
      Location:361 → 957
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:362 → 417
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:349 → 659
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. NM_001338190.1 → NP_001325883.1  WUS-interacting protein 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHS5, Q0WMG2, Q27GK7, Q3EB60, Q9LVZ2
      UniProtKB/TrEMBL
      A0A178VJ72, A0A5S9XCI3
      Conserved Domains (4) summary
      smart00667
      Location:4 → 34
      LisH; Lissencephaly type-1-like homology motif
      smart00668
      Location:34 → 92
      CTLH; C-terminal to LisH motif
      sd00039
      Location:362 → 417
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:349 → 669
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q27GK7.2

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