BRCA2(IV) BREAST CANCER 2 like 2A [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: BRCA2(IV)
Official Full Name: BREAST CANCER 2 like 2A
Primary source: TAIR:AT4G00020
Locus tag: AT4G00020
See related: Araport:AT4G00020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BRCA2A; BREAST CANCER 2 like 2A; EDA20; EMBRYO SAC DEVELOPMENT ARREST 20; F6N15.14; F6N15_14; MATERNAL EFFECT EMBRYO ARREST 43; MEE43
Summary: Ortholog of breast cancer susceptibility protein 2. Essential at meiosis. Interacts with either AtRad51 or AtDmc1 and ATDSS1(I). Involved in embryo sac development and defense gene transcription during plant immune responses.
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See BRCA2(IV) in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 22

Sequence:: Chromosome: 4; NC_003075.7 (2895..10504, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BRCA2 and FIGL1 have antagonistic effects on the dynamics of RAD51/DMC1-dependent DNA transactions to promote accurate HR repair
Title: Antagonism between BRCA2 and FIGL1 regulates homologous recombination.
AtBRCA2 is required for proper meiotic synapsis and mediates the recruitment of AtRAD51 and AtDMC1.[BRCA2A]
Title: BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana.
Study provides the molecular evidence showing that the BRCA2-RAD51 complex, known for its function in HR, also plays a direct and specific role in transcription regulation during plant immune responses.
Title: Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses.
Inefficient DNA repair in the atbrca2a-/atbrca2b double mutant leads to disorganization of the cell cycle of apical meristems.
Title: Inefficient double-strand DNA break repair is associated with increased fasciation in Arabidopsis BRCA2 mutants.
essential role of Brca2 during meiosis in Arabidopsis [BRCA2(IV)]
Title: Brca2 is involved in meiosis in Arabidopsis thaliana as suggested by its interaction with Dmc1.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_001160720.1

Supported by ESTs:

NM_001340223.1

Supported by ESTs:

NM_001340224.1

Supported by ESTs:

NM_001340225.1

Supported by ESTs:

NM_116219.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo sac development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryo sac morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of defense response	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

Go to the top of the page Help

Preferred Names: BREAST CANCER 2 like 2A

NP_001154192.1

BREAST CANCER 2 like 2A (BRCA2(IV)); FUNCTIONS IN: single-stranded DNA binding; INVOLVED IN: meiosis, embryo sac morphogenesis, embryo sac development, embryo development ending in seed dormancy; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), DNA recombination/repair protein BRCA2, helical domain (InterPro:IPR015252), DNA recombination and repair protein, BRCA2 (InterPro:IPR011370), Breast cancer type 2 susceptibility protein (InterPro:IPR015525), BRCA2, oligonucleotide/oligosaccharide-binding 1 (InterPro:IPR015187), BRCA2 repeat (InterPro:IPR002093); BEST Arabidopsis thaliana protein match is: BRCA2-like B (TAIR:AT5G01630.1); Has 319 Blast hits to 211 proteins in 92 species: Archae - 0; Bacteria - 11; Metazoa - 140; Fungi - 22; Plants - 61; Viruses - 0; Other Eukaryotes - 85 (source: NCBI BLink).

NP_191913.3

BREAST CANCER 2 like 2A (BRCA2(IV)); FUNCTIONS IN: single-stranded DNA binding; INVOLVED IN: meiosis, embryo sac morphogenesis, embryo sac development, embryo development ending in seed dormancy; LOCATED IN: nucleus; CONTAINS InterPro DOMAIN/s: Nucleic acid-binding, OB-fold-like (InterPro:IPR016027), DNA recombination/repair protein BRCA2, helical domain (InterPro:IPR015252), DNA recombination and repair protein, BRCA2 (InterPro:IPR011370), BRCA2, oligonucleotide/oligosaccharide-binding 1 (InterPro:IPR015187), Breast cancer type 2 susceptibility protein (InterPro:IPR015525), BRCA2 repeat (InterPro:IPR002093); BEST Arabidopsis thaliana protein match is: BRCA2-like B (TAIR:AT5G01630.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

2895..10504 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001160720.1 → NP_001154192.1 BREAST CANCER 2 like 2A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001154192.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A5S9XNQ9, F4JGU5

Conserved Domains (4) summary

cd04494
Location:750 → 986

BRCA2DBD_OB2; BRCA2DBD_OB2: A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous ...

pfam00634
Location:258 → 288

BRCA2; BRCA2 repeat

pfam09103
Location:619 → 740

BRCA-2_OB1; BRCA2, oligonucleotide/oligosaccharide-binding, domain 1

pfam09169
Location:524 → 615

BRCA-2_helical; BRCA2, helical
NM_116219.5 → NP_191913.3 BREAST CANCER 2 like 2A [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_191913.3

Status: REVIEWED

UniProtKB/Swiss-Prot

O81303, Q7Y1C5, Q9M164

UniProtKB/TrEMBL

A0A5S9XNQ9, A0A654FKI2

Conserved Domains (4) summary

cd04494
Location:755 → 991

BRCA2DBD_OB2; A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated ...

pfam00634
Location:258 → 288

BRCA2; BRCA2 repeat

pfam09103
Location:624 → 745

BRCA-2_OB1; BRCA2, oligonucleotide/oligosaccharide-binding, domain 1

pfam09169
Location:491 → 620

BRCA-2_helical; BRCA2, helical
NM_001340225.1 → NP_001328739.1 BREAST CANCER 2 like 2A [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B5L3, A0A5S9XNQ9

Conserved Domains (4) summary

cd04494
Location:755 → 991

BRCA2DBD_OB2; A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated ...

pfam00634
Location:258 → 288

BRCA2; BRCA2 repeat

pfam09103
Location:624 → 745

BRCA-2_OB1; BRCA2, oligonucleotide/oligosaccharide-binding, domain 1

pfam09169
Location:491 → 620

BRCA-2_helical; BRCA2, helical
NM_001340224.1 → NP_001328737.1 BREAST CANCER 2 like 2A [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UZ83, A0A1P8B5K2

Conserved Domains (4) summary

cd04494
Location:755 → 991

BRCA2DBD_OB2; A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated ...

pfam00634
Location:258 → 288

BRCA2; BRCA2 repeat

pfam09103
Location:624 → 745

BRCA-2_OB1; BRCA2, oligonucleotide/oligosaccharide-binding, domain 1

pfam09169
Location:491 → 620

BRCA-2_helical; BRCA2, helical
NM_001340223.1 → NP_001328738.1 BREAST CANCER 2 like 2A [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178USG7, A0A1P8B5K0

Conserved Domains (4) summary

cd04494
Location:755 → 983

BRCA2DBD_OB2; A subfamily of OB folds corresponding to the second OB fold (OB2) of the 800-amino acid C-terminal ssDNA binding domain (DBD) of BRCA2 (breast cancer susceptibility gene 2) protein, called BRCA2DBD. BRCA2 participates in homologous recombination-mediated ...

pfam00634
Location:258 → 288

BRCA2; BRCA2 repeat

pfam09103
Location:624 → 745

BRCA-2_OB1; BRCA2, oligonucleotide/oligosaccharide-binding, domain 1

pfam09169
Location:491 → 620

BRCA-2_helical; BRCA2, helical