EIF4E eukaryotic translation initiation factor 4E [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: EIF4E
Official Full Name: eukaryotic translation initiation factor 4E
Primary source: TAIR:AT4G18040
Locus tag: AT4G18040
See related: Araport:AT4G18040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA EUKARYOTIC TRANSLATION INITATION FACTOR 4E1; AT.EIF4E1; CUCUMOVIRUS MULTIPLICATION 1; CUM1; eIF4E1; EUKARYOTIC TRANSLATION INITATION FACTOR 4E; eukaryotic translation initiation factor 4E; eukaryotic translation Initiation Factor 4E1; F15J5.10; F15J5_10
Summary: eIF4E protein. The cum1 mutation affects the local spreading of CMV within the inoculated leaf, delaying accumulation of cucumber mosaic virus coat protein.
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Genomic context

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See EIF4E in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 5

Sequence:: Chromosome: 4; NC_003075.7 (10016530..10018232, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The eukaryotic translation initiation factor eIF4E regulates flowering and circadian rhythm in Arabidopsis.
Title: The eukaryotic translation initiation factor eIF4E regulates flowering and circadian rhythm in Arabidopsis.
Arabidopsis eIF4E1 protects the translational machinery during TuMV infection and restricts virus accumulation.
Title: Arabidopsis eIF4E1 protects the translational machinery during TuMV infection and restricts virus accumulation.
The Arabidopsis eIF4E1 regulates NRT1.1-mediated nitrate signaling at both translational and transcriptional levels.
Title: The Arabidopsis eIF4E1 regulates NRT1.1-mediated nitrate signaling at both translational and transcriptional levels.
Interaction of EXA1 and eIF4E Family Members Facilitates Potexvirus Infection in Arabidopsis thaliana.
Title: Interaction of EXA1 and eIF4E Family Members Facilitates Potexvirus Infection in Arabidopsis thaliana.
When a knockout is an Achilles' heel: Resistance to one potyvirus species triggers hypersusceptibility to another one in Arabidopsis thaliana.
Title: When a knockout is an Achilles' heel: Resistance to one potyvirus species triggers hypersusceptibility to another one in Arabidopsis thaliana.
The RALF1-FERONIA Complex Phosphorylates eIF4E1 to Promote Protein Synthesis and Polar Root Hair Growth.
Title: The RALF1-FERONIA Complex Phosphorylates eIF4E1 to Promote Protein Synthesis and Polar Root Hair Growth.
show that SnRK1 over-expression in Nicotiana benthamiana plants reduces polysome formation, and that this effect can be counteracted by transient expression of eIF4E or mutant eIF4E containing non-phosphorylatable SnRK1 target residues, but not by a phosphomimic eIF4E
Title: Phosphorylation of Arabidopsis eIF4E and eIFiso4E by SnRK1 inhibits translation.
CERES (At4g23840) is a eIF4E-interacting protein and contains an LRR domain and a canonical eIF4E-binding site.
Title: A novel eIF4E-interacting protein that forms non-canonical translation initiation complexes.
CBE1(AT4G01290) has an evolutionarily conserved eIF4E-binding motif in its N-terminal domain and binds eIF4E or eIFiso4E.
Title: Discovery and characterization of conserved binding of eIF4E 1 (CBE1), a eukaryotic translation initiation factor 4E-binding plant protein.
Results indicate that nCBP is a novel member of the eIF4E family recessive resistance genes whose loss impairs viral cell-to-cell movement by inhibiting the efficient accumulation of triple-gene-block protein 2 and triple-gene-block protein 3.
Title: Deficiency of the eIF4E isoform nCBP limits the cell-to-cell movement of a plant virus encoding triple-gene-block proteins in Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_117914.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA cap binding	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within translational initiation	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in nucleolus	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: eukaryotic translation initiation factor 4E

NP_193538.1

eukaryotic translation initiation factor 4E (EIF4E); CONTAINS InterPro DOMAIN/s: Eukaryotic translation initiation factor 4E (eIF-4E) (InterPro:IPR001040), Eukaryotic translation initiation factor 4E (eIF-4E), conserved site (InterPro:IPR019770); BEST Arabidopsis thaliana protein match is: Eukaryotic initiation factor 4E protein (TAIR:AT1G29550.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).