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    AAH allantoate amidohydrolase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827752, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AAH
    Official Full Name
    allantoate amidohydrolase
    Primary source
    TAIR:AT4G20070
    Locus tag
    AT4G20070
    See related
    Araport:AT4G20070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    allantoate amidohydrolase; ATAAH; F18F4.170; F18F4_170
    Summary
    The gene encoding Arabidopsis thaliana Allantoate Amidohydrolase (AtAAH)which catalyzes the allantoate deiminase reaction (EC 3.5.3.9)is expressed in all parts of the plant being consistent with a function in purine turnover in Arabidopsis.
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    Genomic context

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    See AAH in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Sequence:
    Chromosome: 4; NC_003075.7 (10861382..10864765)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Pectin lyase-like superfamily protein Neighboring gene ARM repeat superfamily protein Neighboring gene Calcium-dependent lipid-binding (CaLB domain) plant phosphoribosyltransferase family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtAAH encodes a protein with allantoate amidohydrolase activity from Arabidopsis thaliana. Todd CD, et al. Planta, 2006 Apr. PMID 16496096
    2. Identification, biochemical characterization, and subcellular localization of allantoate amidohydrolases from Arabidopsis and soybean. Werner AK, et al. Plant Physiol, 2008 Feb. PMID 18065556, Free PMC Article
    3. The ureide-degrading reactions of purine ring catabolism employ three amidohydrolases and one aminohydrolase in Arabidopsis, soybean, and rice. Werner AK, et al. Plant Physiol, 2013 Oct. PMID 23940254, Free PMC Article
    4. Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Werner AK, et al. Nat Chem Biol, 2010 Jan. PMID 19935661
    5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The isolation and characterization of Allantoate amidohydrolase in A. thaliana and G. max are reported.
      Title: Identification, biochemical characterization, and subcellular localization of allantoate amidohydrolases from Arabidopsis and soybean.
    2. Mutants demonstrated higher allantoate levels than wild-type plants in the presence and absence of exogenous ureides.
      Title: AtAAH encodes a protein with allantoate amidohydrolase activity from Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001341398.1
    NM_118126.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables allantoate deiminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables allantoate deiminase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within purine nucleobase catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within purine nucleobase catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ureide catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within ureide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    allantoate amidohydrolase
    NP_193740.1
    • allantoate amidohydrolase (AAH); CONTAINS InterPro DOMAIN/s: Peptidase M20 (InterPro:IPR002933), ArgE/DapE/ACY1/CPG2/YscS, conserved site (InterPro:IPR001261), Amidase, hydantoinase/carbamoylase (InterPro:IPR010158), Peptidase M20, dimerisation (InterPro:IPR011650); BEST Arabidopsis thaliana protein match is: ureidoglycolate amidohydrolase (TAIR:AT5G43600.1); Has 3541 Blast hits to 3529 proteins in 962 species: Archae - 54; Bacteria - 2502; Metazoa - 32; Fungi - 158; Plants - 88; Viruses - 0; Other Eukaryotes - 707 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      10861382..10864765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118126.4 → NP_193740.1  allantoate amidohydrolase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193740.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49434
      UniProtKB/TrEMBL
      A0A5S9XU55, A0A654FRH5
      Conserved Domains (1) summary
      cd03884
      Location:97 → 522
      M20_bAS; M20 Peptidase beta-alanine synthase, an amidohydrolase

    2. NM_001341398.1 → NP_001329687.1  allantoate amidohydrolase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8I1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O49434.2

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