XCP1 xylem cysteine peptidase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: XCP1
Official Full Name: xylem cysteine peptidase 1
Primary source: TAIR:AT4G35350
Locus tag: AT4G35350
See related: Araport:AT4G35350
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F23E12.90; F23E12_90; xylem cysteine peptidase 1
Summary: tracheary element vacuolar protein
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Genomic context

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See XCP1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (16810482..16812077)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

XCP1 cleaves Pathogenesis-related protein 1 into CAPE9 for systemic immunity in Arabidopsis.
Title: XCP1 cleaves Pathogenesis-related protein 1 into CAPE9 for systemic immunity in Arabidopsis.
XCP1 is specifically expressed in differentiating xylem vessels.
Title: VASCULAR-RELATED NAC-DOMAIN7 directly regulates the expression of a broad range of genes for xylem vessel formation.
XCP1 and XCP2 function in micro-autolysis within the intact central vacuole before mega-autolysis was initiated by tonoplast implosion. XCP1 has a major role and XCP2 has a minor role in micro-autolysis.
Title: Cysteine proteases XCP1 and XCP2 aid micro-autolysis within the intact central vacuole during xylogenesis in Arabidopsis roots.

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General gene information

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Homology

Orthologs from OrthoDB

NM_119701.4

Supported by ESTs:

NM_202958.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cysteine-type peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine precursor processing	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine precursor processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within programmed cell death involved in cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in nucleus	HDA more info	PubMed
located_in plant-type vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: xylem cysteine peptidase 1

NP_567983.1

xylem cysteine peptidase 1 (XCP1); FUNCTIONS IN: cysteine-type endopeptidase activity, cysteine-type peptidase activity; INVOLVED IN: proteolysis, developmental programmed cell death; LOCATED IN: nucleus, plant-type vacuole; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C1A, papain (InterPro:IPR013128), Proteinase inhibitor I29, cathepsin propeptide (InterPro:IPR013201), Peptidase C1A, papain C-terminal (InterPro:IPR000668), Peptidase, cysteine peptidase active site (InterPro:IPR000169); BEST Arabidopsis thaliana protein match is: xylem cysteine peptidase 2 (TAIR:AT1G20850.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_974687.1

xylem cysteine peptidase 1 (XCP1); FUNCTIONS IN: cysteine-type peptidase activity, cysteine-type endopeptidase activity; INVOLVED IN: proteolysis, developmental programmed cell death; LOCATED IN: plant-type vacuole; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 10 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C1A, papain (InterPro:IPR013128), Proteinase inhibitor I29, cathepsin propeptide (InterPro:IPR013201), Peptidase C1A, papain C-terminal (InterPro:IPR000668), Peptidase, cysteine peptidase active site (InterPro:IPR000169); BEST Arabidopsis thaliana protein match is: xylem cysteine peptidase 2 (TAIR:AT1G20850.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16810482..16812077

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119701.4 → NP_567983.1 xylem cysteine peptidase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567983.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65493

UniProtKB/TrEMBL

A0A178UWD3, A0A5S9XYU3

Conserved Domains (2) summary

smart00848
Location:51 → 106

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:137 → 352

Peptidase_C1; Papain family cysteine protease
NM_202958.1 → NP_974687.1 xylem cysteine peptidase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974687.1

Status: REVIEWED

UniProtKB/TrEMBL

F4JN02

Conserved Domains (2) summary

smart00848
Location:51 → 106

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:137 → 287

Peptidase_C1; Papain family cysteine protease