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    BOP1 Ankyrin repeat family protein / BTB/POZ domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824880, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BOP1
    Official Full Name
    Ankyrin repeat family protein / BTB/POZ domain-containing protein
    Primary source
    TAIR:AT3G57130
    Locus tag
    AT3G57130
    See related
    Araport:AT3G57130
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BLADE ON PETIOLE 1
    Summary
    Encodes BOP1. Contains Pfam domain, PF00023: Ankyrin repeat and Pfam domain, PF00651: BTB/POZ domain. Lines carrying recessive mutations exhibit a number of visible defects, most pronounced being ectopic outgrowths of in leaf petioles of rosette leaves. Along with BOP2, BOP1 is required for nectary development and formation of normal abscission zones.Forms homodimers and heterodimers with BOP2. Nuclear localization is required for activity which includes positive regulation of AS2 in leaves. BOP1/2 promotes floral meristem fate and determinacy in a pathway targetting APETALA1 and AGAMOUS-LIKE24. PUCHI, BOP1 and BOP2 are redundantly required for expression of LFY and AP1. BOP1 is expressed in valve margin. Misexpression in stems causes short internodes and ectopic biosynthesis of lignin. BOP1 activity is antagonistic to BP (At4g08150) and PNY (At5g02030). BOP1 expression is restricted to pedicel axils by BP and PNY. BOP1 promotes KNAT6 (At1g23380) expression.
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    Genomic context

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    See BOP1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (21147558..21150238)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene exonuclease V Neighboring gene Protein kinase superfamily protein Neighboring gene sugar-dependent 1-like protein Neighboring gene homologue of NAP57

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The BLADE-ON-PETIOLE 1 gene controls leaf pattern formation through the modulation of meristematic activity in Arabidopsis. Ha CM, et al. Development, 2003 Jan. PMID 12441300
    2. BLADE-ON-PETIOLE1 encodes a BTB/POZ domain protein required for leaf morphogenesis in Arabidopsis thaliana. Ha CM, et al. Plant Cell Physiol, 2004 Oct. PMID 15564519
    3. Analysis of Block of cell proliferation 1 (BOP1) activity in strawberry and Arabidopsis. Carvalho SD, et al. Plant Sci, 2016 Apr. PMID 26940494
    4. Formation and dissociation of the BSS1 protein complex regulates plant development via brassinosteroid signaling. Shimada S, et al. Plant Cell, 2015 Feb. PMID 25663622, Free PMC Article
    5. The BLADE ON PETIOLE genes act redundantly to control the growth and development of lateral organs. Norberg M, et al. Development, 2005 May. PMID 15800002

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clade I TGACG-Motif Binding Basic Leucine Zipper Transcription Factors Mediate BLADE-ON-PETIOLE-Dependent Regulation of Development.
      Title: Clade I TGACG-Motif Binding Basic Leucine Zipper Transcription Factors Mediate BLADE-ON-PETIOLE-Dependent Regulation of Development.
    2. This shows that BOP proteins act as substrate adaptors in a CUL3(BOP1/BOP2) E3 ubiquitin ligase complex, targeting PIF4 proteins for ubiquitination and subsequent degradation.
      Title: BLADE-ON-PETIOLE proteins act in an E3 ubiquitin ligase complex to regulate PHYTOCHROME INTERACTING FACTOR 4 abundance.
    3. functional characterization and role in mechanisms of defective cell growth and proliferation caused by PeBoW deficiency
      Title: Functional characterization of the ribosome biogenesis factors PES, BOP1, and WDR12 (PeBoW), and mechanisms of defective cell growth and proliferation caused by PeBoW deficiency in Arabidopsis.
    4. The conserved protein BOP1 is essential for viability.
      Title: Analysis of Block of cell proliferation 1 (BOP1) activity in strawberry and Arabidopsis.
    5. The BSS1/BOP1 protein complex inhibits the transport of BIL1/BZR1 to the nucleus from the cytosol and negatively regulates brassinosteroid signaling.[BSS1]
      Title: Formation and dissociation of the BSS1 protein complex regulates plant development via brassinosteroid signaling.
    6. Only the reduction of both bop1 and bop2 expression affects resistance triggered by methyl jasmonate.
      Title: The BLADE-ON-PETIOLE genes of Arabidopsis are essential for resistance induced by methyl jasmonate.
    7. BOP1/2 gain-of-function in stems promotes expression of the boundary gene KNOTTED1-LIKE FROM ARABIDOPSIS THALIANA6 (KNAT6) and ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1).
      Title: BLADE-ON-PETIOLE1 and 2 regulate Arabidopsis inflorescence architecture in conjunction with homeobox genes KNAT6 and ATH1.
    8. Data reveal an important supporting role for BOP1/2 in remodeling shoot architecture during the floral transition.
      Title: Arabidopsis BLADE-ON-PETIOLE1 and 2 promote floral meristem fate and determinacy in a previously undefined pathway targeting APETALA1 and AGAMOUS-LIKE24.
    9. BOP1/2 activity is required for AS2 activation specifically in the proximal region of the leaf and that BOP1 is a direct upstream regulator of AS2 during leaf development.
      Title: BLADE-ON-PETIOLE1 coordinates organ determinacy and axial polarity in arabidopsis by directly activating ASYMMETRIC LEAVES2.
    10. BOP1/BOP2 activity is required for multiple cell differentiation events in the proximal regions of inflorescence lateral organs.
      Title: The BLADE-ON-PETIOLE genes are essential for abscission zone formation in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203187.1
    NM_115572.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bract formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within floral meristem determinacy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within floral organ abscission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in floral organ abscission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within flower morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within induced systemic resistance, jasmonic acid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in leaf morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem determinacy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nectary development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in plant organ development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within polarity specification of adaxial/abaxial axis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proximal/distal pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Ankyrin repeat family protein / BTB/POZ domain-containing protein
    NP_001190116.1
    • BLADE ON PETIOLE 1 (BOP1); CONTAINS InterPro DOMAIN/s: BTB/POZ (InterPro:IPR013069), BTB/POZ fold (InterPro:IPR011333), BTB/POZ-like (InterPro:IPR000210); BEST Arabidopsis thaliana protein match is: Ankyrin repeat family protein / BTB/POZ domain-containing protein (TAIR:AT2G41370.1).
    NP_191272.1
    • BLADE ON PETIOLE 1 (BOP1); CONTAINS InterPro DOMAIN/s: BTB/POZ (InterPro:IPR013069), BTB/POZ fold (InterPro:IPR011333), Ankyrin repeat-containing domain (InterPro:IPR020683), BTB/POZ-like (InterPro:IPR000210), Ankyrin repeat (InterPro:IPR002110); BEST Arabidopsis thaliana protein match is: Ankyrin repeat family protein / BTB/POZ domain-containing protein (TAIR:AT2G41370.1); Has 4143 Blast hits to 3880 proteins in 336 species: Archae - 25; Bacteria - 266; Metazoa - 1805; Fungi - 185; Plants - 1045; Viruses - 32; Other Eukaryotes - 785 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21147558..21150238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203187.1 → NP_001190116.1  Ankyrin repeat family protein / BTB/POZ domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190116.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4J257
      Conserved Domains (2) summary
      smart00225
      Location:28 → 163
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00651
      Location:17 → 158
      BTB; BTB/POZ domain

    2. NM_115572.2 → NP_191272.1  Ankyrin repeat family protein / BTB/POZ domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191272.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M1I7
      UniProtKB/TrEMBL
      A0A178VNE2, A0A5S9XMB2
      Conserved Domains (4) summary
      sd00045
      Location:280 → 308
      ANK; ANK repeat [structural motif]
      pfam11900
      Location:199 → 253
      DUF3420; Domain of unknown function (DUF3420)
      cd18310
      Location:10 → 164
      BTB_POZ_NPR_plant; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins
      pfam12796
      Location:260 → 341
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M1I7.1

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